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Research ArticleResearch Article: New Research, Integrative Systems

A Multiscale Closed-Loop Neurotoxicity Model of Alzheimer’s Disease Progression Explains Functional Connectivity Alterations

Jesús Cabrera-Álvarez, Leon Stefanovski, Leon Martin, Gianluca Susi, Fernando Maestú and Petra Ritter
eNeuro 2 April 2024, 11 (4) ENEURO.0345-23.2023; https://doi.org/10.1523/ENEURO.0345-23.2023
Jesús Cabrera-Álvarez
1Department of Experimental Psychology, Complutense University of Madrid, Pozuelo de Alarcón 28223, Spain
2Centre for Cognitive and Computational Neuroscience, Complutense University of Madrid, Madrid 28040, Spain
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  • ORCID record for Jesús Cabrera-Álvarez
Leon Stefanovski
3Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin 10117, Germany
4Department of Neurology with Experimental Neurology, Brain Simulation Section, Charité - Universitätsmedizin Berlin, Berlin 10117, Germany
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Leon Martin
3Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin 10117, Germany
4Department of Neurology with Experimental Neurology, Brain Simulation Section, Charité - Universitätsmedizin Berlin, Berlin 10117, Germany
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Gianluca Susi
2Centre for Cognitive and Computational Neuroscience, Complutense University of Madrid, Madrid 28040, Spain
5Department of Structure of Matter, Thermal Physics and Electronics, Complutense University of Madrid, Madrid 28040, Spain
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Fernando Maestú
1Department of Experimental Psychology, Complutense University of Madrid, Pozuelo de Alarcón 28223, Spain
2Centre for Cognitive and Computational Neuroscience, Complutense University of Madrid, Madrid 28040, Spain
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Petra Ritter
3Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin 10117, Germany
4Department of Neurology with Experimental Neurology, Brain Simulation Section, Charité - Universitätsmedizin Berlin, Berlin 10117, Germany
6Bernstein Center for Computational Neuroscience Berlin, Berlin 10115, Germany
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0345-23.2023
PubMed 
38565295
Published By 
Society for Neuroscience
History 
  • Received September 8, 2023
  • Revision received December 5, 2023
  • Accepted December 22, 2023
  • Published online April 2, 2024.
Copyright & Usage 
Copyright © 2024 Cabrera-Álvarez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Jesús Cabrera-Álvarez1,2,
  2. Leon Stefanovski3,4,
  3. Leon Martin3,4,
  4. Gianluca Susi2,5,
  5. Fernando Maestú1,2 and
  6. Petra Ritter3,4,6
  1. 1Department of Experimental Psychology, Complutense University of Madrid, Pozuelo de Alarcón 28223, Spain
  2. 2Centre for Cognitive and Computational Neuroscience, Complutense University of Madrid, Madrid 28040, Spain
  3. 3Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin 10117, Germany
  4. 4Department of Neurology with Experimental Neurology, Brain Simulation Section, Charité - Universitätsmedizin Berlin, Berlin 10117, Germany
  5. 5Department of Structure of Matter, Thermal Physics and Electronics, Complutense University of Madrid, Madrid 28040, Spain
  6. 6Bernstein Center for Computational Neuroscience Berlin, Berlin 10115, Germany
  1. Correspondence should be addressed to Jesús Cabrera-Álvarez at jescab01{at}ucm.es.
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Author contributions

  1. Author Contributions: J.C.-Á. and G.S. designed research; J.C.-Á., L.S., and L.M. performed research; J.C.-Á. analyzed data; J.C.-Á. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • We thank Spanish Ministry of Universities (FPU2019-04251) and European Union eBRAIN-Health Consortium (HORIZON-101058516).

Funding

  • Spanish Ministry of Universities

    FPU2019-04251
  • European Union eBRAIN-Health consortium

    HORIZON-101058516

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Apr 2024445190225
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A Multiscale Closed-Loop Neurotoxicity Model of Alzheimer’s Disease Progression Explains Functional Connectivity Alterations
Jesús Cabrera-Álvarez, Leon Stefanovski, Leon Martin, Gianluca Susi, Fernando Maestú, Petra Ritter
eNeuro 2 April 2024, 11 (4) ENEURO.0345-23.2023; DOI: 10.1523/ENEURO.0345-23.2023

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A Multiscale Closed-Loop Neurotoxicity Model of Alzheimer’s Disease Progression Explains Functional Connectivity Alterations
Jesús Cabrera-Álvarez, Leon Stefanovski, Leon Martin, Gianluca Susi, Fernando Maestú, Petra Ritter
eNeuro 2 April 2024, 11 (4) ENEURO.0345-23.2023; DOI: 10.1523/ENEURO.0345-23.2023
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Keywords

  • Alzheimer’s disease
  • functional connectivity
  • Jansen–Rit
  • multiscale modeling
  • proteinopathy
  • simulation

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