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Research ArticleResearch Article: New Research, Neuronal Excitability

The Paraventricular Thalamic Nucleus and Its Projections in Regulating Reward and Context Associations

Dillon S. McDevitt, Quinn W. Wade, Greer E. McKendrick, Jacob Nelsen, Mariya Starostina, Nam Tran, Julie A. Blendy and Nicholas M. Graziane
eNeuro 13 February 2024, 11 (2) ENEURO.0524-23.2024; https://doi.org/10.1523/ENEURO.0524-23.2024
Dillon S. McDevitt
1Neuroscience Program, Penn State College of Medicine, Hershey, Pennsylvania 17033
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Quinn W. Wade
2Department of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania 17033
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Greer E. McKendrick
1Neuroscience Program, Penn State College of Medicine, Hershey, Pennsylvania 17033
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Jacob Nelsen
3Doctor of Medicine Program, Penn State College of Medicine, Hershey, Pennsylvania 17033
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Mariya Starostina
3Doctor of Medicine Program, Penn State College of Medicine, Hershey, Pennsylvania 17033
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Nam Tran
3Doctor of Medicine Program, Penn State College of Medicine, Hershey, Pennsylvania 17033
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Julie A. Blendy
4Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
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Nicholas M. Graziane
5Departments of Anesthesiology and Perioperative Medicine and Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania 17033
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0524-23.2024
PubMed 
38351131
Published By 
Society for Neuroscience
History 
  • Received December 11, 2023
  • Revision received January 23, 2024
  • Accepted January 23, 2024
  • Published online February 13, 2024.
Copyright & Usage 
Copyright © 2024 McDevitt et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Dillon S. McDevitt1,
  2. Quinn W. Wade2,
  3. Greer E. McKendrick1,
  4. Jacob Nelsen3,
  5. Mariya Starostina3,
  6. Nam Tran3,
  7. Julie A. Blendy4 and
  8. Nicholas M. Graziane5
  1. 1Neuroscience Program, Penn State College of Medicine, Hershey, Pennsylvania 17033
  2. 2Department of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania 17033
  3. 3Doctor of Medicine Program, Penn State College of Medicine, Hershey, Pennsylvania 17033
  4. 4Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
  5. 5Departments of Anesthesiology and Perioperative Medicine and Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania 17033
  1. Correspondence should be addressed to Nicholas M. Graziane at ngraziane{at}pennstatehealth.psu.edu.
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Author contributions

  1. Author contributions: D.S.M., J.A.B., and N.M.G. designed research; D.S.M., Q.W.W., G.E.M., J.N., M.S., and N.M.G. performed research; N.T. contributed unpublished reagents/analytic tools; D.S.M., Q.W.W., G.E.M., J.N., M.S., and N.M.G. analyzed data; D.S.M., Q.W.W., J.A.B., and N.M.G. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This project is supported by the National Institute on Drug Abuse (DA054374-JAB), Brain and Behavioral Research Foundation [NARSAD Young Investigator Award (27364NG)], the Pennsylvania Department of Health, and the Department of Anesthesiology and Perioperative Medicine at Penn State College of Medicine. We thank Drs. Karl Deisseroth and Bryan Roth for providing viral vectors.

Funding

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    DA054374-JAB
  • Brain and Behavioral Research Foundation

    NARSAD-27364NG
  • Pennsylvania Department of Health (PA DOH)

    NG
  • Department of Anesthesiology and Perioperative Medicine at Penn State College of Medicine

    NG

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The Paraventricular Thalamic Nucleus and Its Projections in Regulating Reward and Context Associations
Dillon S. McDevitt, Quinn W. Wade, Greer E. McKendrick, Jacob Nelsen, Mariya Starostina, Nam Tran, Julie A. Blendy, Nicholas M. Graziane
eNeuro 13 February 2024, 11 (2) ENEURO.0524-23.2024; DOI: 10.1523/ENEURO.0524-23.2024

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The Paraventricular Thalamic Nucleus and Its Projections in Regulating Reward and Context Associations
Dillon S. McDevitt, Quinn W. Wade, Greer E. McKendrick, Jacob Nelsen, Mariya Starostina, Nam Tran, Julie A. Blendy, Nicholas M. Graziane
eNeuro 13 February 2024, 11 (2) ENEURO.0524-23.2024; DOI: 10.1523/ENEURO.0524-23.2024
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Keywords

  • conditioned place preference
  • motivation
  • nucleus accumbens shell
  • opioids
  • paraventricular thalamic nucleus
  • reward

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