Article Information
- Received September 28, 2023
- Revision received December 20, 2023
- Accepted January 12, 2024
- Published online January 23, 2024.
Author Information
- Takashi Yoshida1,
- Syoichi Tashiro1,
- Narihito Nagoshi2,
- Munehisa Shinozaki3,
- Takahiro Shibata2,
- Mitsuhiro Inoue4,
- Shoji Ogawa5,
- Shinsuke Shibata3,6,
- Tetsuya Tsuji1,
- Hideyuki Okano3 and
- Masaya Nakamura2
- 1Departments of Rehabilitation Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
- 2Orthopaedic Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
- 3Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
- 4Regenerative and Cellular Medicine Kobe Center, Sumitomo Pharma, Kobe, Hyogo 650-0047, Japan
- 5Formulation Research & Development Laboratories, Sumitomo Pharma, Suita, Osaka 564-0053, Japan
- 6Division of Microscopic Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata-shi, Niigata 951-8510, Japan
- Correspondence should be addressed to Narihito Nagoshi at nagoshi{at}keio.jp or Syoichi Tashiro at s-tashiro{at}z2.keio.jp.
Author contributions
Author contributions: T.Y., S.T., N.N., M.S., T.S., M.I., S.S., T.T., H.O., and M.N. designed research; T.Y. performed research; T.Y. analyzed data; M.S., M.I., and S.O. contributed unpublished reagents/analytic tools; T.Y., S.T., N.N., M.S., T.S., M.I., S.S., T.T., H.O., and M.N. wrote the paper.
Disclosures
The authors declare no competing financial interests.
We thank for the assistance, comments, and instruction provided by Drs. R. Shibata, K. Kajikawa, Y. Kamata, M. Kawai, T. Kitagawa, K. Ago, T. Nishijima, Y. Saijo, Y. Suematsu, K. Ito, and T. Tanaka and all the members of the Spinal Cord Research Team at the Department of Orthopedic Surgery and Physiology, Keio University School of Medicine, Tokyo, Japan. We thank Prof. S. Yamanaka from Kyoto University, Kyoto, Japan for the human iPSC clones, and Sumitomo Pharma (Hyogo, Japan) for providing the SM-345431.
We also thank K. Yasutake, M. Akizawa, T. Kobayashi, and T. Harada from the Department of Orthopedic Surgery, Keio University School of Medicine, for their assistance with the experiments and animal care. This research was supported by the Japan Agency for Medical Research and Development (AMED) (Grant Nos. JP15bm0204001 and JP23bm1223008).
Funding
Japan Agency for Medical Research and Development (AMED)
JP15bm0204001; JP23bm1223008
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