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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Astrocyte-Derived Exosomal miR-148a-3p Suppresses Neuroinflammation and Restores Neurological Function in Traumatic Brain Injury by Regulating the Microglial Phenotype

Yan Qian, Xin Li, Guiliang Li, Huali Liu, Qiaofen Li, Xia Liu, Yang Zhang, Zongying He, Ying Zhao and Hong Fan
eNeuro 25 January 2024, 11 (2) ENEURO.0336-23.2024; https://doi.org/10.1523/ENEURO.0336-23.2024
Yan Qian
1Rehabilitation Medicine, Qujing No.1 Hospital, Qujing, Yunnan 655000, China
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Xin Li
1Rehabilitation Medicine, Qujing No.1 Hospital, Qujing, Yunnan 655000, China
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Guiliang Li
1Rehabilitation Medicine, Qujing No.1 Hospital, Qujing, Yunnan 655000, China
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Huali Liu
1Rehabilitation Medicine, Qujing No.1 Hospital, Qujing, Yunnan 655000, China
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Qiaofen Li
1Rehabilitation Medicine, Qujing No.1 Hospital, Qujing, Yunnan 655000, China
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Xia Liu
1Rehabilitation Medicine, Qujing No.1 Hospital, Qujing, Yunnan 655000, China
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Yang Zhang
1Rehabilitation Medicine, Qujing No.1 Hospital, Qujing, Yunnan 655000, China
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Zongying He
1Rehabilitation Medicine, Qujing No.1 Hospital, Qujing, Yunnan 655000, China
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Ying Zhao
2Rehabilitation Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, China
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Hong Fan
2Rehabilitation Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, China
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0336-23.2024
PubMed 
38272675
Published By 
Society for Neuroscience
History 
  • Received August 31, 2023
  • Revision received December 29, 2023
  • Accepted January 1, 2024
  • Published online January 25, 2024.
Copyright & Usage 
Copyright © 2024 Qian et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Yan Qian1,*,
  2. Xin Li1,*,
  3. Guiliang Li1,
  4. Huali Liu1,
  5. Qiaofen Li1,
  6. Xia Liu1,
  7. Yang Zhang1,
  8. Zongying He1,
  9. Ying Zhao2 and
  10. Hong Fan2
  1. 1Rehabilitation Medicine, Qujing No.1 Hospital, Qujing, Yunnan 655000, China
  2. 2Rehabilitation Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, China
  1. Correspondence should be addressed to Ying Zhao at 13987461702{at}163.com or Hong Fan at 13769693710{at}163.com.
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Author contributions

  1. Author contributions: Y.Q., X.L., G.L., H.L., Y.Z., and H.F. designed research; Y.Q., X.L., G.L., X.L., and Z.H. performed research; Y.Q., X.L., G.L., H.L., Q.L., Y.Z., and H.F. analyzed data; Y.Z. and Y.Z. contributed unpublished reagents/analytic tools; Y.Q., X.L., H.L., Q.L., X.L., Y.Z., and H.F. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • Training Project of Yunnan Rehabilitation Clinical Medical Center, Subject No. ZX2019-04-02.

  • ↵*Y.Q. and X.L. contributed equally to this work.

Funding

  • Training Project of Yunnan Rehabilitation Clinical Medical Center

    ZX2019-04-02

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  • previous version (January 25, 2024).

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Astrocyte-Derived Exosomal miR-148a-3p Suppresses Neuroinflammation and Restores Neurological Function in Traumatic Brain Injury by Regulating the Microglial Phenotype
Yan Qian, Xin Li, Guiliang Li, Huali Liu, Qiaofen Li, Xia Liu, Yang Zhang, Zongying He, Ying Zhao, Hong Fan
eNeuro 25 January 2024, 11 (2) ENEURO.0336-23.2024; DOI: 10.1523/ENEURO.0336-23.2024

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Astrocyte-Derived Exosomal miR-148a-3p Suppresses Neuroinflammation and Restores Neurological Function in Traumatic Brain Injury by Regulating the Microglial Phenotype
Yan Qian, Xin Li, Guiliang Li, Huali Liu, Qiaofen Li, Xia Liu, Yang Zhang, Zongying He, Ying Zhao, Hong Fan
eNeuro 25 January 2024, 11 (2) ENEURO.0336-23.2024; DOI: 10.1523/ENEURO.0336-23.2024
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Keywords

  • exosomes
  • inflammatory response
  • microglial phenotype
  • neurological function
  • traumatic brain injury

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