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Research ArticleResearch Article: New Research, Neuronal Excitability

Tonic NMDAR Currents of NR2A-Containing NMDARs Represent Altered Ambient Glutamate Concentration in the Supraoptic Nucleus

Hyunjin Shin, Ramesh Sharma, Chiranjivi Neupane, Thuy Linh Pham, Su Eun Park, So Yeong Lee, Hyun-Woo Kim, Young Min Bae, Javier E. Stern and Jin Bong Park
eNeuro 4 January 2024, 11 (2) ENEURO.0279-23.2023; https://doi.org/10.1523/ENEURO.0279-23.2023
Hyunjin Shin
1Department of Physiology & Medical Science, College of Medicine & Brain Research Institute, Chungnam National University, Daejeon 35015, South Korea
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Ramesh Sharma
1Department of Physiology & Medical Science, College of Medicine & Brain Research Institute, Chungnam National University, Daejeon 35015, South Korea
2Laboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea
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  • ORCID record for Ramesh Sharma
Chiranjivi Neupane
2Laboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea
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Thuy Linh Pham
1Department of Physiology & Medical Science, College of Medicine & Brain Research Institute, Chungnam National University, Daejeon 35015, South Korea
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Su Eun Park
1Department of Physiology & Medical Science, College of Medicine & Brain Research Institute, Chungnam National University, Daejeon 35015, South Korea
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So Yeong Lee
2Laboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea
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Hyun-Woo Kim
1Department of Physiology & Medical Science, College of Medicine & Brain Research Institute, Chungnam National University, Daejeon 35015, South Korea
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Young Min Bae
3Department of Physiology, Konkuk University School of Medicine, Chungju 27478, Republic of Korea
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Javier E. Stern
4Neuroscience Institute and Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, Georgia 30302
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Jin Bong Park
2Laboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0279-23.2023
PubMed 
38176904
Published By 
Society for Neuroscience
History 
  • Received July 26, 2023
  • Revision received December 3, 2023
  • Accepted December 21, 2023
  • Published online January 4, 2024.
Copyright & Usage 
Copyright © 2024 Shin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Hyunjin Shin1,*,
  2. Ramesh Sharma1,2,*,
  3. Chiranjivi Neupane2,
  4. Thuy Linh Pham1,
  5. Su Eun Park1,
  6. So Yeong Lee2,
  7. Hyun-Woo Kim1,
  8. Young Min Bae3,
  9. Javier E. Stern4 and
  10. Jin Bong Park2
  1. 1Department of Physiology & Medical Science, College of Medicine & Brain Research Institute, Chungnam National University, Daejeon 35015, South Korea
  2. 2Laboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea
  3. 3Department of Physiology, Konkuk University School of Medicine, Chungju 27478, Republic of Korea
  4. 4Neuroscience Institute and Center for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, Georgia 30302
  1. Correspondence should be addressed to Jin Bong Park at jbpark{at}snu.ac.kr.
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Author contributions

  1. Author contributions: R.S., H.-W.K., and J.B.P. designed research; H.S., R.S., C.N., S.E.P., T.L.P., and J.E.S. performed research; S.Y.L. and Y.M.B. contributed unpublished reagents and analytical tools; H.S., R.S., C.N., S.E.P., T.L.P., H.-W.K., Y.M.B., J.E.S., and J.B.P. analyzed data; R.S. and J.B.P. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Research Foundation of Korea (NRF, 2021R1I1A3051864 and 2023R1A2C100524811 to J.B.P.), the New Faculty Startup Fund from Seoul National University (550-20220057 to J.B.P.), the National Heart, Lung, and Blood Institute Grant (NIH HL090948 to J.E.S.), and the National Institute of Neurological Disorders and Stroke Grant (NIH NS094640 to J.E.S.).

  • ↵*H.S. and R.S. contributed equally to this work.

Funding

  • National Research Foundation of Korea (NRF)

    2021R1I1A3051864; 2023R1A2C100524811
  • New Faculty Startup Fund from Seoul National University

    550-20220057
  • National Heart, Lung, and Blood Institute Grant

    NIH HL090948
  • National Institute of Neurological Disorders and Stroke Grant

    NIH NS094640

Other Version

  • You are viewing the most recent version of this article.
  • previous version (January 04, 2024).

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Tonic NMDAR Currents of NR2A-Containing NMDARs Represent Altered Ambient Glutamate Concentration in the Supraoptic Nucleus
Hyunjin Shin, Ramesh Sharma, Chiranjivi Neupane, Thuy Linh Pham, Su Eun Park, So Yeong Lee, Hyun-Woo Kim, Young Min Bae, Javier E. Stern, Jin Bong Park
eNeuro 4 January 2024, 11 (2) ENEURO.0279-23.2023; DOI: 10.1523/ENEURO.0279-23.2023

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Tonic NMDAR Currents of NR2A-Containing NMDARs Represent Altered Ambient Glutamate Concentration in the Supraoptic Nucleus
Hyunjin Shin, Ramesh Sharma, Chiranjivi Neupane, Thuy Linh Pham, Su Eun Park, So Yeong Lee, Hyun-Woo Kim, Young Min Bae, Javier E. Stern, Jin Bong Park
eNeuro 4 January 2024, 11 (2) ENEURO.0279-23.2023; DOI: 10.1523/ENEURO.0279-23.2023
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Keywords

  • NMDARS
  • NR2A
  • SON MNCs

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