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Research ArticleResearch Article: Negative Results, Disorders of the Nervous System

Mice Expressing A53T/A30P Mutant Alpha-Synuclein in Dopamine Neurons Do Not Display Behavioral Deficits

Cameron Keomanivong, Josephine Schamp, Ervina Tabakovic, Ramasamy Thangavel, Georgina Aldridge, Andrew A. Pieper and Nandakumar S. Narayanan
eNeuro 13 February 2024, 11 (2) ENEURO.0170-23.2023; https://doi.org/10.1523/ENEURO.0170-23.2023
Cameron Keomanivong
1Carver College of Medicine, University of Iowa, Iowa City 52245, Iowa
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Josephine Schamp
2York University, York 68467, Nebraska
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Ervina Tabakovic
1Carver College of Medicine, University of Iowa, Iowa City 52245, Iowa
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Ramasamy Thangavel
3Department of Neurology, University of Iowa, Iowa City 52245, Iowa
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Georgina Aldridge
3Department of Neurology, University of Iowa, Iowa City 52245, Iowa
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Andrew A. Pieper
4Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland 44106, Ohio; Department of Psychiatry, Case Western Reserve University, Cleveland 44106, Ohio; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland 44106, Ohio; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland 44106, Ohio; Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland 44106, Ohio; Department of Neuroscience, School of Medicine, Case Western Reserve University, Cleveland 44106, Ohio; Translational Therapeutics Core, Cleveland Alzheimer’s Disease Research Center, Cleveland, Ohio
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Nandakumar S. Narayanan
3Department of Neurology, University of Iowa, Iowa City 52245, Iowa
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0170-23.2023
PubMed 
38351057
Published By 
Society for Neuroscience
History 
  • Received May 22, 2023
  • Revision received December 13, 2023
  • Accepted December 19, 2023
  • Published online February 13, 2024.
Copyright & Usage 
Copyright © 2024 Keomanivong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Cameron Keomanivong1,*,
  2. Josephine Schamp2,*,
  3. Ervina Tabakovic1,
  4. Ramasamy Thangavel3,
  5. Georgina Aldridge3,
  6. Andrew A. Pieper4 and
  7. Nandakumar S. Narayanan3
  1. 1Carver College of Medicine, University of Iowa, Iowa City 52245, Iowa
  2. 2York University, York 68467, Nebraska
  3. 3Department of Neurology, University of Iowa, Iowa City 52245, Iowa
  4. 4Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland 44106, Ohio; Department of Psychiatry, Case Western Reserve University, Cleveland 44106, Ohio; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland 44106, Ohio; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland 44106, Ohio; Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland 44106, Ohio; Department of Neuroscience, School of Medicine, Case Western Reserve University, Cleveland 44106, Ohio; Translational Therapeutics Core, Cleveland Alzheimer’s Disease Research Center, Cleveland, Ohio
  1. Correspondence should be addressed to Nandakumar S. Narayanan at nandakumar-narayanan{at}uiowa.edu.
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Author contributions

  1. Author contributions: C.K., J.S., G.A., A.A.P., and N.S.N. designed research; C.K., J.S., R.T., and G.A. performed research; C.K., J.S., E.T., and N.S.N. analyzed data; C.K., G.A., A.A.P., and N.S.N. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Titan Neurological Fund.

  • ↵*C.K. and J.S. contributed equally to this work.

Funding

  • Titan Neurological Fund

Online Impact

 

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Article usage: February 2024 to December 2025

AbstractFullPdf
Feb 2024202480166
Mar 20244116056
Apr 20241615841
May 20241412355
Jun 202499227
Jul 202469628
Aug 2024127824
Sep 2024118222
Oct 202486116
Nov 2024107820
Dec 202438732
Total 20243321495487
Jan 20251010638
Feb 2025117920
Mar 2025810721
Apr 202529620
May 202558223
Jun 202569923
Jul 2025414023
Aug 2025217617
Sep 2025622520
Oct 2025419927
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Dec 20255717
Total 2025691627258
Total4013122745
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Mice Expressing A53T/A30P Mutant Alpha-Synuclein in Dopamine Neurons Do Not Display Behavioral Deficits
Cameron Keomanivong, Josephine Schamp, Ervina Tabakovic, Ramasamy Thangavel, Georgina Aldridge, Andrew A. Pieper, Nandakumar S. Narayanan
eNeuro 13 February 2024, 11 (2) ENEURO.0170-23.2023; DOI: 10.1523/ENEURO.0170-23.2023

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Mice Expressing A53T/A30P Mutant Alpha-Synuclein in Dopamine Neurons Do Not Display Behavioral Deficits
Cameron Keomanivong, Josephine Schamp, Ervina Tabakovic, Ramasamy Thangavel, Georgina Aldridge, Andrew A. Pieper, Nandakumar S. Narayanan
eNeuro 13 February 2024, 11 (2) ENEURO.0170-23.2023; DOI: 10.1523/ENEURO.0170-23.2023
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Keywords

  • animal models
  • replication
  • behavior
  • dopamine
  • midbrain

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