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Research ArticleResearch Article: Negative Results, Disorders of the Nervous System

Mice Expressing A53T/A30P Mutant Alpha-Synuclein in Dopamine Neurons Do Not Display Behavioral Deficits

Cameron Keomanivong, Josephine Schamp, Ervina Tabakovic, Ramasamy Thangavel, Georgina Aldridge, Andrew A. Pieper and Nandakumar S. Narayanan
eNeuro 13 February 2024, 11 (2) ENEURO.0170-23.2023; https://doi.org/10.1523/ENEURO.0170-23.2023
Cameron Keomanivong
1Carver College of Medicine, University of Iowa, Iowa City 52245, Iowa
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Josephine Schamp
2York University, York 68467, Nebraska
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Ervina Tabakovic
1Carver College of Medicine, University of Iowa, Iowa City 52245, Iowa
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Ramasamy Thangavel
3Department of Neurology, University of Iowa, Iowa City 52245, Iowa
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Georgina Aldridge
3Department of Neurology, University of Iowa, Iowa City 52245, Iowa
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Andrew A. Pieper
4Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland 44106, Ohio; Department of Psychiatry, Case Western Reserve University, Cleveland 44106, Ohio; Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland VA Medical Center, Cleveland 44106, Ohio; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland 44106, Ohio; Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland 44106, Ohio; Department of Neuroscience, School of Medicine, Case Western Reserve University, Cleveland 44106, Ohio; Translational Therapeutics Core, Cleveland Alzheimer’s Disease Research Center, Cleveland, Ohio
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Nandakumar S. Narayanan
3Department of Neurology, University of Iowa, Iowa City 52245, Iowa
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eneuro: 11 (2)
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February 2024
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Mice Expressing A53T/A30P Mutant Alpha-Synuclein in Dopamine Neurons Do Not Display Behavioral Deficits
Cameron Keomanivong, Josephine Schamp, Ervina Tabakovic, Ramasamy Thangavel, Georgina Aldridge, Andrew A. Pieper, Nandakumar S. Narayanan
eNeuro 13 February 2024, 11 (2) ENEURO.0170-23.2023; DOI: 10.1523/ENEURO.0170-23.2023

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Mice Expressing A53T/A30P Mutant Alpha-Synuclein in Dopamine Neurons Do Not Display Behavioral Deficits
Cameron Keomanivong, Josephine Schamp, Ervina Tabakovic, Ramasamy Thangavel, Georgina Aldridge, Andrew A. Pieper, Nandakumar S. Narayanan
eNeuro 13 February 2024, 11 (2) ENEURO.0170-23.2023; DOI: 10.1523/ENEURO.0170-23.2023
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Keywords

  • animal models
  • replication
  • behavior
  • dopamine
  • midbrain

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