Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro
eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleResearch Article: New Research, Disorders of the Nervous System

Axonal Organelle Buildup from Loss of AP-4 Complex Function Causes Exacerbation of Amyloid Plaque Pathology and Gliosis in Alzheimer's Disease Mouse Model

Alex Orlowski, Joseph Karippaparambil, Jean-Michel Paumier, Shraddha Ghanta, Eduardo Pallares, Rumamol Chandran, Daisy Edmison, Jamuna Tandukar, Ruixuan Gao and Swetha Gowrishankar
eNeuro 4 December 2024, 11 (12) ENEURO.0445-24.2024; https://doi.org/10.1523/ENEURO.0445-24.2024
Alex Orlowski
1Department of Anatomy and Cell Biology, College of Medicine, University of Illinois Chicago, Chicago, Illinois 60612
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joseph Karippaparambil
1Department of Anatomy and Cell Biology, College of Medicine, University of Illinois Chicago, Chicago, Illinois 60612
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jean-Michel Paumier
1Department of Anatomy and Cell Biology, College of Medicine, University of Illinois Chicago, Chicago, Illinois 60612
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shraddha Ghanta
1Department of Anatomy and Cell Biology, College of Medicine, University of Illinois Chicago, Chicago, Illinois 60612
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eduardo Pallares
1Department of Anatomy and Cell Biology, College of Medicine, University of Illinois Chicago, Chicago, Illinois 60612
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rumamol Chandran
1Department of Anatomy and Cell Biology, College of Medicine, University of Illinois Chicago, Chicago, Illinois 60612
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daisy Edmison
1Department of Anatomy and Cell Biology, College of Medicine, University of Illinois Chicago, Chicago, Illinois 60612
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jamuna Tandukar
2Department of Biological Sciences, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, Illinois 60607
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ruixuan Gao
2Department of Biological Sciences, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, Illinois 60607
3Department of Chemistry, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, Illinois 60607
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Swetha Gowrishankar
1Department of Anatomy and Cell Biology, College of Medicine, University of Illinois Chicago, Chicago, Illinois 60612
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0445-24.2024
PubMed 
39632089
Published By 
Society for Neuroscience
History 
  • Received October 18, 2024
  • Revision received November 20, 2024
  • Accepted November 22, 2024
  • Published online December 4, 2024.
Copyright & Usage 
Copyright © 2024 Orlowski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Alex Orlowski1,
  2. Joseph Karippaparambil1,
  3. Jean-Michel Paumier1,*,
  4. Shraddha Ghanta1,*,
  5. Eduardo Pallares1,
  6. Rumamol Chandran1,
  7. Daisy Edmison1,
  8. Jamuna Tandukar2,
  9. Ruixuan Gao2,3 and
  10. Swetha Gowrishankar1
  1. 1Department of Anatomy and Cell Biology, College of Medicine, University of Illinois Chicago, Chicago, Illinois 60612
  2. 2Department of Biological Sciences, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, Illinois 60607
  3. 3Department of Chemistry, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, Illinois 60607
  1. Correspondence should be addressed to Swetha Gowrishankar at swethag{at}uic.edu.
View Full Text

Author contributions

  1. Author contributions: A.O., J.K., and Sw.G. designed research; A.O., J.K., J.-M.P., Sh.G., E.P., R.C., D.E., J.T., R.G., and Sw.G. performed research; A.O., J.K., J.-M.P., R.C., J.T., R.G., and Sw.G. analyzed data; A.O. and Sw.G. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Wolverine Foundation (Sw.G.), The Ralph and Marian Falk Medical Trust (Sw.G.), the National Institute on Aging of the National Institutes of Health [RF1AG076653 (Sw.G.), R01AG074248 (Sw.G.)], National Institutes of Health [DP2MH136390 (R.G.), UG3MH126864 (R.G.)], Searle Scholars Program (R.G.), McKnight Technological Innovations in Neuroscience Award (R.G.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

  • ↵*J.-M.P. and Sh.G. contributed equally to this work.

Funding

  • National Institute of Aging

    RF1AG076653; R01AG074248
  • Wolverine Foundation

  • The Ralph and Marian Falk Medical Trust

  • HHS | National Institutes of Health (NIH)

    DP2MH136390; UG3MH126864
  • Searle Scholars Program (SSP)

  • McKnight Technological Innovations in Neuroscience Award

Other Version

  • You are viewing the most recent version of this article.
  • previous version (December 04, 2024).

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-12-14
to
E.g., 2025-12-14

Article usage: December 2024 to December 2025

AbstractFullPdf
Dec 202444439192
Total 202444439192
Jan 202521917091
Feb 20251216634
Mar 20251066648
Apr 20251246465
May 20251056838
Jun 20251437642
Jul 20251098151
Aug 20255010756
Sep 20251517030
Oct 2025712432
Nov 20251014125
Dec 202554428
Total 202510141177540
Total14581216732
Back to top

In this issue

eneuro: 11 (12)
eNeuro
Vol. 11, Issue 12
December 2024
  • Table of Contents
  • Index by author
  • Masthead (PDF)
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Axonal Organelle Buildup from Loss of AP-4 Complex Function Causes Exacerbation of Amyloid Plaque Pathology and Gliosis in Alzheimer's Disease Mouse Model
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Axonal Organelle Buildup from Loss of AP-4 Complex Function Causes Exacerbation of Amyloid Plaque Pathology and Gliosis in Alzheimer's Disease Mouse Model
Alex Orlowski, Joseph Karippaparambil, Jean-Michel Paumier, Shraddha Ghanta, Eduardo Pallares, Rumamol Chandran, Daisy Edmison, Jamuna Tandukar, Ruixuan Gao, Swetha Gowrishankar
eNeuro 4 December 2024, 11 (12) ENEURO.0445-24.2024; DOI: 10.1523/ENEURO.0445-24.2024

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Axonal Organelle Buildup from Loss of AP-4 Complex Function Causes Exacerbation of Amyloid Plaque Pathology and Gliosis in Alzheimer's Disease Mouse Model
Alex Orlowski, Joseph Karippaparambil, Jean-Michel Paumier, Shraddha Ghanta, Eduardo Pallares, Rumamol Chandran, Daisy Edmison, Jamuna Tandukar, Ruixuan Gao, Swetha Gowrishankar
eNeuro 4 December 2024, 11 (12) ENEURO.0445-24.2024; DOI: 10.1523/ENEURO.0445-24.2024
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
    • Synthesis
    • Author Response
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • adaptor
  • Alzheimer’s disease
  • amyloid
  • axonal pathology
  • lysosome
  • microglia

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Research Article: New Research

  • Anxiety-associated behaviors following ablation of Miro1 from cortical excitatory neurons
  • Altered excitability and glutamatergic synaptic transmission in the medium spiny neurons of the nucleus accumbens in mice deficient in the heparan sulfate endosulfatase Sulf1
  • Different but complementary motor functions reveal an asymmetric recalibration of upper limb bimanual coordination
Show more Research Article: New Research

Disorders of the Nervous System

  • Altered PI3K/mTOR signaling within the forebrain leads to respiratory deficits in a mouse model of epilepsy
  • Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer's Disease
  • The PDGFBB-PDGFRβ Pathway and Laminins in Pericytes Are Involved in the Temporal Change of AQP4 Polarity during Temporal Lobe Epilepsy Pathogenesis
Show more Disorders of the Nervous System

Subjects

  • Disorders of the Nervous System
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.