Article Information
- Received July 2, 2024
- Revision received November 21, 2024
- Accepted November 27, 2024
- Published online December 10, 2024.
Author Information
- Christine S. Liu1,2,*,
- Chris Park1,2,*,
- Tony Ngo1,*,
- Janani Saikumar1,
- Carter R. Palmer1,2,
- Anis Shahnaee1,
- William J. Romanow1 and
- Jerold Chun1
- 1Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037
- 2Biomedical Sciences Program, School of Medicine, University of California San Diego, La Jolla, California 92093
- Correspondence should be addressed to Jerold Chun at jchun{at}sbpdiscovery.org.
Author contributions
Author contributions: C.S.L., C.P., T.N., J.S., C.R.P., and J.C. designed research; C.S.L., C.P., T.N., J.S., C.R.P., A.S., and W.J.R. performed research; C.S.L. contributed unpublished reagents/analytic tools; C.S.L., C.P., T.N., and J.S. analyzed data; C.S.L., C.P., T.N., J.S., and J.C. wrote the paper.
Disclosures
The authors declare no competing financial interests.
This work was in part supported by National Institutes of Health (NIH) Grants R01 AG071465 and R01AG065541, DoD Grant W81XWH-21-10642, and the Bruce Ford and Anne Smith Bundy Foundation and the Larry L. Hillblom Foundation (to J.C); the UC San Diego Cellular and Molecular Pharmacology training Grant T32GM007752 (to C.S.L.); and CIRM Postdoctoral Fellowship EDUC4-12813-01 (to T.N.). We thank Danielle Jones for administrative assistance, Laura Wolszon for sourcing and obtaining human brain specimens, and the Sanford Burnham Prebys Genomics Core for performing RNA integrity number analysis of brain samples.
We also thank the donors and families who shared these precious brain materials, of which were obtained from: Emory Alzheimer’s Disease Research Center (ADRC; NIH P50AG025688), NIH NeuroBioBank, Parkinson’s UK Brain Bank [a charity registered in England and Wales (258197) and Scotland (SC037554)], and UC San Diego ADRC (NIH P30AG062429). J.C. has an employment relationship with Neurocrine Biosciences, Inc., unrelated to the current work. J.C.'s relationship with Neurocrine Biosciences, Inc. has been reviewed and approved by Sanford Burnham Prebys Medical Discovery Institute in accordance with its Conflict-of-Interest Policies.
↵*C.S.L., C.P., and T.N. contributed equally to this work.
Funding
NIH
R01 AG071465; R01AG065541; T32GM007752DOD
W81XWH-21-10642-01CIRM
EDUC4-12813-01Bruce Ford and Anne Smith Bundy Foundation
Larry L Hillblom Foundation
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