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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Prenatal Exposure to MAM Impairs mPFC and Hippocampal Inhibitory Function in Mice during Adolescence and Adulthood

Zhiyin He, Qian He, Xiaorong Tang, Keni Huang, Yiwen Lin, Jianrui Xu, Qiliang Chen, Nenggui Xu and Lulu Yao
eNeuro 5 November 2024, 11 (11) ENEURO.0362-24.2024; https://doi.org/10.1523/ENEURO.0362-24.2024
Zhiyin He
1South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
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Qian He
1South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
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Xiaorong Tang
1South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
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Keni Huang
1South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
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Yiwen Lin
1South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
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Jianrui Xu
1South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
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Qiliang Chen
2School of Basic Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
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Nenggui Xu
1South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
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Lulu Yao
1South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0362-24.2024
PubMed 
39500572
Published By 
Society for Neuroscience
History 
  • Received August 21, 2024
  • Revision received October 26, 2024
  • Accepted October 29, 2024
  • Published online November 5, 2024.
Copyright & Usage 
Copyright © 2024 He et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Zhiyin He1,
  2. Qian He1,
  3. Xiaorong Tang1,
  4. Keni Huang1,
  5. Yiwen Lin1,
  6. Jianrui Xu1,
  7. Qiliang Chen2,
  8. Nenggui Xu1 and
  9. Lulu Yao1
  1. 1South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
  2. 2School of Basic Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
  1. Correspondence should be addressed to Lulu Yao at yaolulu{at}gzucm.edu.cn or Nenggui Xu at ngxu8018{at}gzucm.edu.cn.
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Author contributions

  1. Author contributions: Z.H., Q.C., N.X., and L.Y. designed research; Z.H., Q.H., X.T., and K.H. performed research; Z.H., Q.H., X.T., K.H., Y.L., and J.X. analyzed data; Z.H., Q.H., and L.Y. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This research was supported by the Guangzhou Basic and Applied Basic Research Foundation (No. 2023A04J2474) awarded to L.Y., Natural Science Foundation of Guangdong Province (No. 2024A1515012282) awarded to L.Y., and Traditional Chinese Medicine Bureau of Guangdong Province, General program (No. 20231104) awarded to Q.C.

Funding

  • Guangzhou Basic and Applied Basic Research Foundation

    2023A04J2474
  • GDSTC | Natural Science Foundation of Guangdong Province (廣東省自然科學基金)

    2024A1515012282
  • Traditional Chinese Medicine Bureau of Guangdong Province

    20231104

Other Version

  • You are viewing the most recent version of this article.
  • previous version (November 05, 2024).

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Prenatal Exposure to MAM Impairs mPFC and Hippocampal Inhibitory Function in Mice during Adolescence and Adulthood
Zhiyin He, Qian He, Xiaorong Tang, Keni Huang, Yiwen Lin, Jianrui Xu, Qiliang Chen, Nenggui Xu, Lulu Yao
eNeuro 5 November 2024, 11 (11) ENEURO.0362-24.2024; DOI: 10.1523/ENEURO.0362-24.2024

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Prenatal Exposure to MAM Impairs mPFC and Hippocampal Inhibitory Function in Mice during Adolescence and Adulthood
Zhiyin He, Qian He, Xiaorong Tang, Keni Huang, Yiwen Lin, Jianrui Xu, Qiliang Chen, Nenggui Xu, Lulu Yao
eNeuro 5 November 2024, 11 (11) ENEURO.0362-24.2024; DOI: 10.1523/ENEURO.0362-24.2024
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Keywords

  • hippocampus
  • inhibitory function
  • medial prefrontal cortex
  • methylazoxymethanol acetate
  • neuronal activity
  • parvalbumin
  • schizophrenia

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