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Research ArticleResearch Article: Negative Results, Cognition and Behavior

Fragile Mentalizing: Lack of Behavioral and Neural Markers of Social Cognition in an Established Social Perspective Taking Task when Combined with Stress Induction

Simrandeep Cheema, Calina Augustin, Martin Göttlich, Ulrike M. Krämer and Frederike Beyer
eNeuro 26 November 2024, 11 (11) ENEURO.0084-24.2024; https://doi.org/10.1523/ENEURO.0084-24.2024
Simrandeep Cheema
1Department of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, United Kingdom
2University of Wolverhampton, Wolverhampton WV1 1LY, United Kingdom
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Calina Augustin
3Department of Neurology, University of Lübeck, Lübeck 23562, Germany
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Martin Göttlich
4Institute of Medical Psychology, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck 23562, Germany
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Ulrike M. Krämer
4Institute of Medical Psychology, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck 23562, Germany
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Frederike Beyer
1Department of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, United Kingdom
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  • ORCID record for Frederike Beyer
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Article Figures & Data

Figures

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  • Figure 1.
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    Figure 1.

    Task outline. A, The trial outline of the ball detection task (El Kaddouri et al., 2020). An example trial of the stress induction task is shown in B and a trial of the control task in C. D, The order of tasks.

  • Figure 2.
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    Figure 2.

    Behavioral data. The figure shows the ToM-indexes for the control and stress conditions for the first experiment (online study) and the second experiment (MRI study). Error bars show standard errors of the mean. None of the displayed measures were significantly different from 0 (p < 0.05 two-tailed).

  • Figure 3.
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    Figure 3.

    Task outline: A, Timing of the ball detection task. B, An example trial of the stress induction. Feedback bar is presented at the top of the screen, and the timer is below this.

  • Figure 4.
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    Figure 4.

    ROI data. The figure shows fMRI contrast values for the four regions of interest, separately for the three models run, and for the four experimental conditions (congruent and incongruent trials in the control and stress conditions).

Tables

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    Table 1.

    Mixed linear model effects

    Coeff.2.5% CI97.5% CIt valuep value
    Model 1
     Participant belief−0.015−0.020−0.009−4.84<0.001
     Agent belief−0.001−0.0070.005−0.400.688
     Participant * agent<0.001−0.0050.007−0.250.805
    Model 2
     Participant belief−0.014−0.020−0.009−4.83<0.001
     Agent belief−0.001−0.0070.005−0.400.688
     Stress-<0.006−0.012<0.001−1.950.051
     Participant * agent<0.001−0.0050.0070.240.813
     Participant * stress−0.001−0.0070.005−0.380.703
     Agent * stress−0.002−0.0080.004−0.650.514
     Participant * agent * stress0.002−0.0040.0080.780.436
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    Table 2.

    Linear regression model testing effect of exercise and emotion regulation on implicit mentalizing (SEM, standard error of the mean)

    ßstandSEMtp
    ToM-index stress
     ERQ cognitive reappraisal−0.251.52−1.930.10
     ERQ expressive suppression−0.252.13−1.960.08
     Exercise cutoff group0.1015.520.780.44
    ToM-index stress
     ERQ cognitive reappraisal−0.382.17−0.280.78
     ERQ expressive suppression−0.023.04−0.140.89
     Exercise cutoff group0.0722.150.500.62
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    Table 3.

    ANOVA test statistics

    FDegrees of freedomError degrees of freedomp value
    Condition0.00411170.950
    Study0.07611170.783
    Condition * study1.62211170.205
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    Table 4.

    Mixed model effects for Study 2

    Coeff.2.5% CI97.5% CIt valuep value
    Model 1
     Participant belief−0.014−0.019−0.009−5.81<0.001
     Agent belief−0.003−0.0080.002−1.200.229
     Participant * agent<0.001−0.0050.004−0.140.891
    Model 2
     Participant belief−0.014−0.019−0.009−5.80<0.001
     Agent belief−0.003−0.0080.002−1.210.227
     Stress-<0.001−0.0050.005−0.010.990
     Participant * agent-<0.001−0.0050.004−0.130.894
     Participant * stress-<0.001−0.0060.004−0.350.724
     Agent * stress<0.001−0.0050.0050.070.945
     Participant * agent * stress−0.002−0.0070.002−0.980.327
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    Table 5.

    Linear regression testing effect of exercise, physiological regulation, and emotion regulation on implicit mentalizing. (SEM, standard error of the mean)

    ßstandSEMtp
    ToM-index control
     ERQ cognitive adaptive−0.141.42−1.930.36
     ERQ cognitive maladaptive−0.151.91−1.960.37
     Exercise group0.0915.890.640.53
     HRV−0.160.31−1.120.27
    ToM-index stress
     ERQ cognitive adaptive0.151.540.920.36
     ERQ cognitive maladaptive−0.052.07−0.330.74
     Exercise−0.0117.22−0.100.92
     HRV0.160.331.150.26
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    Table 6.

    Statistical tests on regions of interest analyses

    t (p)
    rTPJrMTGrLINGrSMG
    MODEL 1
     Control incongruent > congruent−0.26(0.794) BF(10) = 0.155−1.92 (0.060) BF(10) = 0.815−0.45 (0.654) BF(10) = 0.165−0.81 (0.424) BF(10) = 0.204
     Stress incongruent > congruent1.09 (0.280) BF(10) = 0.263−1.13 (0.268) BF(10) = 0.273−1.19 (0.240) BF(10) = 0.2920.06 (0.948) BF(10) = 0.150
     Stress × difference in congruency−1.03 (0.308) BF(10) = 0.247−0.77 (0.444) BF(10) = 0.1980.49 (0.628) BF(10) = 0.168−0.67 (0.508) BF(10) = 0.185
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    Table 7.

    Statistical tests on post hoc exploratory analyses of different GLM models

    t (p)
    rTPJrMTGrLINGrSMG
    Exploratory Model 1: 9 s regressor of interest
     Control incongruent > congruent−0.91(0.368) BF(10) = 0.221−2.97 (0.004) BF(10) = 7.378−0.90 (0.370) BF(10) = 0.220−2.75 (0.008) BF(10) = 4.378
     Stress incongruent > congruent1.03 (0.306) BF(10) = 0.248−0.88 (0.386) BF(10) = 0.2150.18 (0.860) BF(10) = 0.1521.15 (0.842) BF(10) = 0.279
    Exploratory Model 2: participant belief formation phase only
     Control incongruent > congruent−0.24 (0.812) BF(10) = 0.154−1.95 (0.056) BF(10) = 0.863−0.33 (0.744) BF(10) = 0.158−0.84 (0.402) BF(10) = 0.210
     Stress incongruent > congruent1.08 (0.282) BF(10) = 0.260−1.11 (0.272) BF(10) = 0.268−1.07 (0.290) BF(10) = 0.2570.12 (0.908) BF(10) = 0.151
    • t coefficients and p values reported outside and inside the brackets, respectively.

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Fragile Mentalizing: Lack of Behavioral and Neural Markers of Social Cognition in an Established Social Perspective Taking Task when Combined with Stress Induction
Simrandeep Cheema, Calina Augustin, Martin Göttlich, Ulrike M. Krämer, Frederike Beyer
eNeuro 26 November 2024, 11 (11) ENEURO.0084-24.2024; DOI: 10.1523/ENEURO.0084-24.2024

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Fragile Mentalizing: Lack of Behavioral and Neural Markers of Social Cognition in an Established Social Perspective Taking Task when Combined with Stress Induction
Simrandeep Cheema, Calina Augustin, Martin Göttlich, Ulrike M. Krämer, Frederike Beyer
eNeuro 26 November 2024, 11 (11) ENEURO.0084-24.2024; DOI: 10.1523/ENEURO.0084-24.2024
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Keywords

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