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Research ArticleResearch Article: New Research, Neuronal Excitability

Tetrahydroxy Stilbene Glucoside Promotes Mitophagy and Ameliorates Neuronal Injury after Cerebral Ischemia Reperfusion via Promoting USP10-Mediated YBX1 Stability

Yuxian Li, Ke Hu, Jie Li, Xirong Yang, Xiuyu Wu, Qian Liu, Yuefu Chen, Yan Ding, Lingli Liu, Qiansheng Yang and Guangwei Wang
eNeuro 15 October 2024, 11 (10) ENEURO.0269-24.2024; https://doi.org/10.1523/ENEURO.0269-24.2024
Yuxian Li
1Medical College, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
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Ke Hu
1Medical College, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
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Jie Li
2School of Basic Medical Sciences, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
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Xirong Yang
3Department of Neurology, first affiliated hospital, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
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Xiuyu Wu
2School of Basic Medical Sciences, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
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Qian Liu
4Biomedical Research Center, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
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Yuefu Chen
1Medical College, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
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Yan Ding
1Medical College, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
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Lingli Liu
1Medical College, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
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Qiansheng Yang
1Medical College, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
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Guangwei Wang
4Biomedical Research Center, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0269-24.2024
PubMed 
39406480
Published By 
Society for Neuroscience
History 
  • Received June 20, 2024
  • Revision received September 13, 2024
  • Accepted October 3, 2024
  • Published online October 15, 2024.
Copyright & Usage 
Copyright © 2024 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Yuxian Li1,*,
  2. Ke Hu1,*,
  3. Jie Li2,*,
  4. Xirong Yang3,
  5. Xiuyu Wu2,
  6. Qian Liu4,
  7. Yuefu Chen1,
  8. Yan Ding1,
  9. Lingli Liu1,
  10. Qiansheng Yang1 and
  11. Guangwei Wang4
  1. 1Medical College, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
  2. 2School of Basic Medical Sciences, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
  3. 3Department of Neurology, first affiliated hospital, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
  4. 4Biomedical Research Center, Hunan University of Medicine, Huaihua, Hunan Province 418000, China
  1. Correspondence should be addressed to Guangwei Wang at hnyywgw{at}163.com.
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Author contributions

  1. Author contributions: Y.L., K.H., and J.L. designed research; Y.L., K.H., J.L., X.Y., X.W., and Q.L. performed research; X.Y., X.W., Q.L., and G.W. contributed unpublished reagents/analytic tools; Y.C., Y.D., L.L., and Q.Y. analyzed data; Y.L., K.H., J.L., Y.C., Y.D., L.L., Q.Y., and G.W. wrote the paper.

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Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Joint project of Hunan Provincial Natural Science Foundation (2023JJ50437) and Joint project of Hunan Provincial Natural Science Foundation (2024JJ7322).

  • ↵*Y.L., K.H., and J.L. are the co-first authors.

Funding

  • Joint project of Hunan Provincial Natural Science Foundation

    2023JJ50437; 2024JJ7322

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  • previous version (October 15, 2024).

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Oct 2024291128143
Nov 202446290135
Dec 202420191110
Total 2024357609388
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Tetrahydroxy Stilbene Glucoside Promotes Mitophagy and Ameliorates Neuronal Injury after Cerebral Ischemia Reperfusion via Promoting USP10-Mediated YBX1 Stability
Yuxian Li, Ke Hu, Jie Li, Xirong Yang, Xiuyu Wu, Qian Liu, Yuefu Chen, Yan Ding, Lingli Liu, Qiansheng Yang, Guangwei Wang
eNeuro 15 October 2024, 11 (10) ENEURO.0269-24.2024; DOI: 10.1523/ENEURO.0269-24.2024

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Tetrahydroxy Stilbene Glucoside Promotes Mitophagy and Ameliorates Neuronal Injury after Cerebral Ischemia Reperfusion via Promoting USP10-Mediated YBX1 Stability
Yuxian Li, Ke Hu, Jie Li, Xirong Yang, Xiuyu Wu, Qian Liu, Yuefu Chen, Yan Ding, Lingli Liu, Qiansheng Yang, Guangwei Wang
eNeuro 15 October 2024, 11 (10) ENEURO.0269-24.2024; DOI: 10.1523/ENEURO.0269-24.2024
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Keywords

  • ischemic stroke
  • mitophagy
  • PINK1/Parkin
  • tetrahydroxy stilbene glucoside
  • USP10
  • YBX1

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