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Research ArticleResearch Article: New Research, Cognition and Behavior

BMP Antagonist Gremlin 2 Regulates Hippocampal Neurogenesis and Is Associated with Seizure Susceptibility and Anxiety

Nicolette B. Frazer, Garrett A. Kaas, Caroline G. Firmin, Eric R. Gamazon and Antonis K. Hatzopoulos
eNeuro 30 September 2024, 11 (10) ENEURO.0213-23.2024; https://doi.org/10.1523/ENEURO.0213-23.2024
Nicolette B. Frazer
1Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37232
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Garrett A. Kaas
2Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232
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Caroline G. Firmin
2Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232
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Eric R. Gamazon
1Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37232
2Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232
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Antonis K. Hatzopoulos
1Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37232
3Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0213-23.2024
PubMed 
39349059
Published By 
Society for Neuroscience
History 
  • Received June 19, 2023
  • Revision received July 15, 2024
  • Accepted July 18, 2024
  • Published online September 30, 2024.
Copyright & Usage 
Copyright © 2024 Frazer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Nicolette B. Frazer1,
  2. Garrett A. Kaas2,
  3. Caroline G. Firmin2,
  4. Eric R. Gamazon1,2 and
  5. Antonis K. Hatzopoulos1,3
  1. 1Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37232
  2. 2Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232
  3. 3Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232
  1. Correspondence should be addressed to Antonis K. Hatzopoulos at antonis.hatzopoulos{at}vumc.org.
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Author contributions

  1. Author contributions: N.B.F., E.R.G., and A.K.H. designed research; N.B.F., G.A.K., and C.G.F. performed research; N.B.F. and A.K.H. analyzed data; N.B.F. and A.K.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • We thank the Vanderbilt Mouse Neurobehavioral Lab and the director, Dr. Fiona A. Harrison, for the outstanding assistance and advice on the design and execution of the neurobehavioral tests. We also thank the Vanderbilt Digital Histology Shared Resource for the outstanding services. Image analysis and presentation were performed in part through the use of the Vanderbilt Cell Imaging Shared Resource (supported by National Institutes of Health (NIH) Grants CA68485, DK20593, DK58404, DK59637, and EY08126).

  • This work was supported by grants from the National Heart, Lung, and Blood Institute (NHLBI) of the NIH (R01HL138519) and the Department of Defense (W81XWH-16-1-0622) to A.K.H. and NIH National Human Genome Research Institute (R35HG010718, R01HG011138) and National Institute on Aging (R56AG068026) to E.R.G.

Funding

  • HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)

    R01HL138519
  • DoD

    W81XWH-16-1-0622
  • HHS | NIH | National Human Genome Research Institute (NHGRI)

    R35HG010718; R01HG011138
  • HHS | NIH | National Institute on Aging (NIA)

    R56AG068026

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  • previous version (September 30, 2024).

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BMP Antagonist Gremlin 2 Regulates Hippocampal Neurogenesis and Is Associated with Seizure Susceptibility and Anxiety
Nicolette B. Frazer, Garrett A. Kaas, Caroline G. Firmin, Eric R. Gamazon, Antonis K. Hatzopoulos
eNeuro 30 September 2024, 11 (10) ENEURO.0213-23.2024; DOI: 10.1523/ENEURO.0213-23.2024

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BMP Antagonist Gremlin 2 Regulates Hippocampal Neurogenesis and Is Associated with Seizure Susceptibility and Anxiety
Nicolette B. Frazer, Garrett A. Kaas, Caroline G. Firmin, Eric R. Gamazon, Antonis K. Hatzopoulos
eNeuro 30 September 2024, 11 (10) ENEURO.0213-23.2024; DOI: 10.1523/ENEURO.0213-23.2024
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Keywords

  • anxiety
  • BMP signaling
  • epilepsy
  • Gremlin 2
  • hippocampal neurogenesis

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