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Research ArticleResearch Article: New Research, Neuronal Excitability

Intranasal Delivery of Ketamine Induces Cortical Disinhibition

Xin Qiao, Steven F. Grieco, Zhaoxia Yu, Todd C. Holmes and Xiangmin Xu
eNeuro 14 December 2023, 11 (1) ENEURO.0107-23.2023; https://doi.org/10.1523/ENEURO.0107-23.2023
Xin Qiao
1Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine 92697, California
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Steven F. Grieco
1Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine 92697, California
2Center for Neural Circuit Mapping, University of California, Irvine 92697, California
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Zhaoxia Yu
2Center for Neural Circuit Mapping, University of California, Irvine 92697, California
3Department of Statistics, Donald Bren School of Information and Computer Sciences, Irvine 92697, California
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Todd C. Holmes
2Center for Neural Circuit Mapping, University of California, Irvine 92697, California
4Department of Physiology and Biophysics, School of Medicine, University of California, Irvine 92697, California
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  • ORCID record for Todd C. Holmes
Xiangmin Xu
1Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine 92697, California
2Center for Neural Circuit Mapping, University of California, Irvine 92697, California
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0107-23.2023
PubMed 
38164560
Published By 
Society for Neuroscience
History 
  • Received March 27, 2023
  • Revision received November 2, 2023
  • Accepted November 21, 2023
  • Published online December 14, 2023.
Copyright & Usage 
Copyright © 2024 Qiao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Xin Qiao1,
  2. Steven F. Grieco1,2,
  3. Zhaoxia Yu2,3,
  4. Todd C. Holmes2,4 and
  5. Xiangmin Xu1,2
  1. 1Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine 92697, California
  2. 2Center for Neural Circuit Mapping, University of California, Irvine 92697, California
  3. 3Department of Statistics, Donald Bren School of Information and Computer Sciences, Irvine 92697, California
  4. 4Department of Physiology and Biophysics, School of Medicine, University of California, Irvine 92697, California
  1. Correspondence should be addressed to Xiangmin Xu at xiangmix{at}hs.uci.edu.
View Full Text

Author contributions

  1. Author contributions: X.X. designed research; X.Q. and S.F.G. performed research; X.Q., S.F.G., and Z.Y. analyzed data; S.F.G., T.C.H., and X.X. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health (NIH) grants R01NS078434, R01NS104897, and RF1AG065675 to X.X., R35 GM127102 to T.C.H., and Knights Templar Eye Foundation (KTEF) grant KTEF-5646361 to S.F.G.

  • S.Q. and S.F.G. contributed equally to this work.

Funding

  • HHS | National Institutes of Health (NIH)

    R01NS078434; R01NS104897; RF1AG065675; GM127102
  • Knights Templar Eye Foundation (KTEF)

    KTEF-5646361

Other Version

  • You are viewing the most recent version of this article.
  • previous version (December 14, 2023).

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Article usage: December 2023 to January 2026

AbstractFullPdf
Dec 20232930107
Total 20232930107
Jan 2024172200147
Feb 20244516963
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Apr 20242967552
May 20241813826
Jun 20241511831
Jul 2024812034
Aug 2024159016
Sep 20241110426
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Total 20243552049528
Jan 20251211855
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Mar 2025912539
Apr 2025812027
May 2025710517
Jun 20251711827
Jul 2025910272
Aug 2025108337
Sep 20251613213
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Nov 20252815926
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Jan 2026169118
Total 2026169118
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Intranasal Delivery of Ketamine Induces Cortical Disinhibition
Xin Qiao, Steven F. Grieco, Zhaoxia Yu, Todd C. Holmes, Xiangmin Xu
eNeuro 14 December 2023, 11 (1) ENEURO.0107-23.2023; DOI: 10.1523/ENEURO.0107-23.2023

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Intranasal Delivery of Ketamine Induces Cortical Disinhibition
Xin Qiao, Steven F. Grieco, Zhaoxia Yu, Todd C. Holmes, Xiangmin Xu
eNeuro 14 December 2023, 11 (1) ENEURO.0107-23.2023; DOI: 10.1523/ENEURO.0107-23.2023
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Keywords

  • depression
  • disinhibition
  • intranasal
  • ketamine
  • parvalbumin
  • visual cortex

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