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Research ArticleResearch Article: New Research, Sensory and Motor Systems

Nicotine Decreases Nerve Regeneration and Pain Behaviors via PTEN and Downstream Inflammation-Related Pathway in Two Rat Nerve Injury Models

Yehong Fang, Tingkai Zhang, Ling Li, Shanshan Chen, Liangliang Wang, Jinsong Tang and Yanhui Liao
eNeuro 24 August 2023, 10 (9) ENEURO.0185-23.2023; https://doi.org/10.1523/ENEURO.0185-23.2023
Yehong Fang
Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, People’s Republic of China
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  • ORCID record for Yehong Fang
Tingkai Zhang
Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, People’s Republic of China
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Ling Li
Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, People’s Republic of China
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Shanshan Chen
Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, People’s Republic of China
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Liangliang Wang
Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, People’s Republic of China
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Jinsong Tang
Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, People’s Republic of China
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Yanhui Liao
Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, People’s Republic of China
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0185-23.2023
PubMed 
37620149
Published By 
Society for Neuroscience
History 
  • Received May 29, 2023
  • Revision received July 14, 2023
  • Accepted August 8, 2023
  • Published online August 24, 2023.
Copyright & Usage 
Copyright © 2023 Fang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Yehong Fang*,
  2. Tingkai Zhang*,
  3. Ling Li,
  4. Shanshan Chen,
  5. Liangliang Wang,
  6. Jinsong Tang and
  7. Yanhui Liao
  1. Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, People’s Republic of China
  1. Correspondence should be addressed to Yanhui Liao at liaoyanhui{at}zju.edu.cn.
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Author contributions

  1. Author contributions: Y.F., J.T., and Y.L. designed research; Y.F. and T.Z. performed research; L.W. contributed unpublished reagents/analytic tools; Y.F. and T.Z. analyzed data; Y.F., T.Z., L.L., and S.C. wrote the paper.

  2. ↵* Y.F. and T.Z. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Science Foundation of China (Grant U22A20302), Scientific and Technological Innovation 2030–Major Projects (Grant 2022ZD0211200), and the China Medical Board (Grant 22-485).

Funding

  • The National Science Foundation of China

    #U22A20302
  • STI 2030 - Major projects

    2022ZD0211200
  • the China Medical Board

    #22-485

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  • You are viewing the most recent version of this article.
  • previous version (August 24, 2023).

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eneuro: 10 (9)
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Vol. 10, Issue 9
September 2023
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Nicotine Decreases Nerve Regeneration and Pain Behaviors via PTEN and Downstream Inflammation-Related Pathway in Two Rat Nerve Injury Models
Yehong Fang, Tingkai Zhang, Ling Li, Shanshan Chen, Liangliang Wang, Jinsong Tang, Yanhui Liao
eNeuro 24 August 2023, 10 (9) ENEURO.0185-23.2023; DOI: 10.1523/ENEURO.0185-23.2023

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Nicotine Decreases Nerve Regeneration and Pain Behaviors via PTEN and Downstream Inflammation-Related Pathway in Two Rat Nerve Injury Models
Yehong Fang, Tingkai Zhang, Ling Li, Shanshan Chen, Liangliang Wang, Jinsong Tang, Yanhui Liao
eNeuro 24 August 2023, 10 (9) ENEURO.0185-23.2023; DOI: 10.1523/ENEURO.0185-23.2023
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Keywords

  • nicotine
  • nerve regeneration
  • neuropathic pain
  • α7-nAChR
  • Pten

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