Article Figures & Data
Figures
- Figure 1.
Somatosensory Nose-poke Adapted paradigm (SNAP). A, Photograph illustrating the SNAP chamber consisting of a 17.5 inch (W) × 17.5 inch (L) × 24 inch (H) acrylic, open box. B, C, Photograph of the 2-inch elevated platform contained in the SNAP chamber. The platform has six ¾ inches in diameter holes in the center. Half of the holes are lined with 80 grit sandpaper whereas the other half do not.
- Figure 2.
Behavioral sensory assessment. A, Bar graphs of the number of nose pokes into rough and smooth holes, BTBR and Cntnap2−/− produced more rough than smooth nose pokes relative to neurotypical mice, p < 0.001. B, Bar graphs of the percentage of nose pokes into rough and smooth holes, BTBR and Cntnap2−/− produced a higher percentage of rough than smooth nose pokes relative to neurotypical mice, p < 0.0001. Data are represented as the mean ± SEM.
- Figure 3.
Stereotypy, anxiety, and locomotion assessment in SNAP. A, Bar graphs of the total number of nose pokes for each mouse line. BTBR mice generated more nose pokes than all other lines, indicative of increased stereotypy (difference between A and B notations for stereotypy, p < 0.0001). B, Bar graphs of the time spent in the center of the paradigm, a measure of anxiety. BTBR mice spent more time in the center than all other groups (difference between A and B notations for anxiety, p < 001). C, Bar graphs of the distance traveled, a measure of locomotion. C57 mice traveled significantly less than all other groups (difference between A and B notations for locomotion p < 0.0002). D, Representative track plots of C57, CD-1, Cntnap2−/−, and BTBR mice. Data are represented as the mean ± SEM.
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