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Research ArticleResearch Article: New Research, Neuronal Excitability

Isoflurane Alters Presynaptic Endoplasmic Reticulum Calcium Dynamics in Wild-Type and Malignant Hyperthermia-Susceptible Rodent Hippocampal Neurons

Vanessa Osman, Iris Speigel, Kishan Patel and Hugh C. Hemmings Jr
eNeuro 17 August 2023, 10 (8) ENEURO.0114-23.2023; https://doi.org/10.1523/ENEURO.0114-23.2023
Vanessa Osman
1Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065
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Iris Speigel
2Department of Anesthesiology, Weill Cornell Medical College, New York, NY 10065
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Kishan Patel
2Department of Anesthesiology, Weill Cornell Medical College, New York, NY 10065
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Hugh C. Hemmings Jr
1Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065
2Department of Anesthesiology, Weill Cornell Medical College, New York, NY 10065
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0114-23.2023
PubMed 
37591734
Published By 
Society for Neuroscience
History 
  • Received April 5, 2023
  • Revision received July 28, 2023
  • Accepted August 9, 2023
  • Published online August 17, 2023.
Copyright & Usage 
Copyright © 2023 Osman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Vanessa Osman1,
  2. Iris Speigel2,
  3. Kishan Patel2 and
  4. Hugh C. Hemmings Jr1,2
  1. 1Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065
  2. 2Department of Anesthesiology, Weill Cornell Medical College, New York, NY 10065
  1. Correspondence should be addressed to Hugh C. Hemmings at hchemmi{at}med.cornell.edu.
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Author contributions

  1. Author contributions: V.O. and H.C.H. designed research; V.O., I.S., and K.P. performed research; V.O. analyzed data; V.O. and H.C.H. wrote the paper.

Disclosures

  • H.C.H. is the Editor-in-Chief of the British Journal of Anaesthesia. All other authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants GM58055 (to H.C.H.) and GM133115 (to V.O.).

Funding

  • HHS | NIH | National Institute of General Medical Sciences (NIGMS)

    GM50885; GM133115

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  • You are viewing the most recent version of this article.
  • previous version (August 17, 2023).

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Aug 202329869150
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Total64937901252
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eneuro: 10 (8)
eNeuro
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August 2023
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Isoflurane Alters Presynaptic Endoplasmic Reticulum Calcium Dynamics in Wild-Type and Malignant Hyperthermia-Susceptible Rodent Hippocampal Neurons
Vanessa Osman, Iris Speigel, Kishan Patel, Hugh C. Hemmings Jr
eNeuro 17 August 2023, 10 (8) ENEURO.0114-23.2023; DOI: 10.1523/ENEURO.0114-23.2023

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Isoflurane Alters Presynaptic Endoplasmic Reticulum Calcium Dynamics in Wild-Type and Malignant Hyperthermia-Susceptible Rodent Hippocampal Neurons
Vanessa Osman, Iris Speigel, Kishan Patel, Hugh C. Hemmings Jr
eNeuro 17 August 2023, 10 (8) ENEURO.0114-23.2023; DOI: 10.1523/ENEURO.0114-23.2023
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Keywords

  • anesthesia
  • calcium
  • endoplasmic reticulum
  • exocytosis
  • isoflurane
  • malignant hyperthermia
  • presynaptic
  • propofol
  • sevoflurane
  • synaptic vesicle

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