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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Estradiol- and Progesterone-Associated Changes in microRNA-Induced Silencing and Reduced Antiseizure Efficacy of an Antagomir in Female Mice

Durgesh Tiwari, Valerine Rajathi, Jeffrey K. Rymer, Lindsay N. Beasley, Amanda M. McGann, Alexander T. Bunk, Emma V. Parkins, McKenzie F. Rice, Katie E. Smith, David M. Ritter, Angela R. White, Carolyn M. Doerning and Christina Gross
eNeuro 11 July 2023, 10 (7) ENEURO.0047-22.2023; https://doi.org/10.1523/ENEURO.0047-22.2023
Durgesh Tiwari
1Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229
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Valerine Rajathi
1Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
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Jeffrey K. Rymer
1Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
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Lindsay N. Beasley
1Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
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Amanda M. McGann
1Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
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Alexander T. Bunk
1Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
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Emma V. Parkins
1Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
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McKenzie F. Rice
1Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
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Katie E. Smith
3Veterinary Services, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
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David M. Ritter
1Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229
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Angela R. White
1Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
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Carolyn M. Doerning
2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229
3Veterinary Services, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
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Christina Gross
1Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0047-22.2023
PubMed 
37433683
Published By 
Society for Neuroscience
History 
  • Received January 29, 2022
  • Revision received June 6, 2023
  • Accepted June 12, 2023
  • Published online July 11, 2023.
Copyright & Usage 
Copyright © 2023 Tiwari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Durgesh Tiwari1,2,
  2. Valerine Rajathi1,
  3. Jeffrey K. Rymer1,
  4. Lindsay N. Beasley1,
  5. Amanda M. McGann1,
  6. Alexander T. Bunk1,
  7. Emma V. Parkins1,
  8. McKenzie F. Rice1,
  9. Katie E. Smith3,
  10. David M. Ritter1,2,
  11. Angela R. White1,
  12. Carolyn M. Doerning2,3 and
  13. Christina Gross1,2
  1. 1Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
  2. 2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229
  3. 3Veterinary Services, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229
  1. Correspondence should be addressed to Christina Gross at christina.gross{at}cchmc.org.
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Author contributions

  1. Author contributions: D.T., C.M.D., and C.G. designed research; D.T., V.R., J.K.R., L.N.B., A.M.M., A.T.B., E.V.P., M.F.R., K.E.S., D.M.R., and A.R.W. performed research; D.T., V.R., J.K.R., L.N.B., A.T.B., E.V.P., M.F.R., D.M.R., and C.G. analyzed data; D.T. and C.G. wrote the paper.

Disclosures

  • C.G. is a coinventor on US Patent 9,932,585 B2. The authors declare no other competing finanicial interests.

  • This work was supported by National Institutes of Health Grants R01NS092705 and R01NS107453 (to C.G.), and T32NS007453 (predoctoral Fellowship to E.V.P.); American Epilepsy Society Postdoctoral Fellowship 506835 (to D.T.); the Cincinnati Children’s Hospital Medical Center Research Innovation in Support of Excellence Award (to D.M.R.), and the Cincinnati Children’s Research Foundation.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R01NS092705; R01NS107453; T32NS007453
  • American Epilepsy Society (AES)

    506835
  • Cincinnati Children's Research Foundation (CCRF)

    RISE Award

Other Version

  • You are viewing the most recent version of this article.
  • previous version (July 11, 2023).

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Article usage: July 2023 to April 2026

AbstractFullPdf
Jul 2023344125117
Aug 20233614843
Sep 20232513928
Oct 20231818133
Nov 2023109717
Dec 20231717443
Total 2023450864281
Jan 20241914931
Feb 20241511021
Mar 202479822
Apr 20241511031
May 2024128915
Jun 202479316
Jul 202449025
Aug 2024169539
Sep 2024138421
Oct 202448720
Nov 202449333
Dec 202417219
Total 20241171170293
Jan 202568820
Feb 202548815
Mar 2025410318
Apr 202538318
May 2025310119
Jun 20251410717
Jul 20251113232
Aug 20251011523
Sep 20251416724
Oct 2025615531
Nov 20251113620
Dec 20251012130
Total 2025961396267
Jan 20261213624
Feb 20261025025
Mar 20261916551
Apr 202663823
Total 202647589123
Total7104019964
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Estradiol- and Progesterone-Associated Changes in microRNA-Induced Silencing and Reduced Antiseizure Efficacy of an Antagomir in Female Mice
Durgesh Tiwari, Valerine Rajathi, Jeffrey K. Rymer, Lindsay N. Beasley, Amanda M. McGann, Alexander T. Bunk, Emma V. Parkins, McKenzie F. Rice, Katie E. Smith, David M. Ritter, Angela R. White, Carolyn M. Doerning, Christina Gross
eNeuro 11 July 2023, 10 (7) ENEURO.0047-22.2023; DOI: 10.1523/ENEURO.0047-22.2023

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Estradiol- and Progesterone-Associated Changes in microRNA-Induced Silencing and Reduced Antiseizure Efficacy of an Antagomir in Female Mice
Durgesh Tiwari, Valerine Rajathi, Jeffrey K. Rymer, Lindsay N. Beasley, Amanda M. McGann, Alexander T. Bunk, Emma V. Parkins, McKenzie F. Rice, Katie E. Smith, David M. Ritter, Angela R. White, Carolyn M. Doerning, Christina Gross
eNeuro 11 July 2023, 10 (7) ENEURO.0047-22.2023; DOI: 10.1523/ENEURO.0047-22.2023
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Keywords

  • epilepsy
  • female
  • microRNA
  • miR-324-5p
  • Kv4.2

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