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Research ArticleResearch Article: New Research, Sensory and Motor Systems

Spinal Sensorimotor Circuits Play a Prominent Role in Hindlimb Locomotor Recovery after Staggered Thoracic Lateral Hemisections but Cannot Restore Posture and Interlimb Coordination during Quadrupedal Locomotion in Adult Cats

Johannie Audet, Sirine Yassine, Charly G. Lecomte, Stephen Mari, Félix Soucy, Caroline Morency, Angèle N. Merlet, Jonathan Harnie, Claudie Beaulieu, Louis Gendron, Ilya A. Rybak, Boris I. Prilutsky and Alain Frigon
eNeuro 16 June 2023, 10 (6) ENEURO.0191-23.2023; https://doi.org/10.1523/ENEURO.0191-23.2023
Johannie Audet
1Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
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Sirine Yassine
1Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
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Charly G. Lecomte
1Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
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Stephen Mari
1Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
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Félix Soucy
1Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
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Caroline Morency
1Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
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Angèle N. Merlet
1Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
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Jonathan Harnie
1Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
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Claudie Beaulieu
1Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
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Louis Gendron
1Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
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Ilya A. Rybak
2Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129
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Boris I. Prilutsky
3School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332
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Alain Frigon
1Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0191-23.2023
PubMed 
37328297
Published By 
Society for Neuroscience
History 
  • Received June 1, 2023
  • Revision received June 5, 2023
  • Accepted June 6, 2023
  • Published online June 16, 2023.
Copyright & Usage 
Copyright © 2023 Audet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Johannie Audet1,*,
  2. Sirine Yassine1,*,
  3. Charly G. Lecomte1,
  4. Stephen Mari1,
  5. Félix Soucy1,
  6. Caroline Morency1,
  7. Angèle N. Merlet1,
  8. Jonathan Harnie1,
  9. Claudie Beaulieu1,
  10. Louis Gendron1,
  11. Ilya A. Rybak2,
  12. Boris I. Prilutsky3 and
  13. Alain Frigon1
  1. 1Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
  2. 2Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA 19129
  3. 3School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332
  1. Correspondence should be addressed to Alain Frigon at alain.frigon{at}usherbrooke.ca.
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Author contributions

  1. Author contributions: I.A.R., B.I.P., and A.F. designed research; J.A., S.Y., C.G.L., S.M., F.S., C.M., A.N.M., and J.H. performed research; J.A., S.Y., C.B., L.G., and A.F. analyzed data; J.A., S.Y., C.G.L., S.M., F.S., C.M., A.N.M., J.H., C.B., L.G., I.A.R., B.I.P., and A.F. wrote the paper.

  2. ↵* J.A. and S.Y. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) Grant RGPIN-2016-03790 (to A.F.) and the National Institutes of Health Grant R01 NS110550 (to A.F., I.A.R., and B.I.P.). A.F. is a Fonds de Recherche-Santé Quebec (FRQS) Senior Research Scholar. J.H. and A.N.M. were supported by FRQS doctoral and postdoctoral scholarships, respectively. J.A. was supported by master’s scholarships from NSERC and a doctoral scholarship from FRQS. C.B. was supported by a master’s scholarship from the Canadian Institutes of Health Research.

Funding

  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)

    RGPIN-2016-03790
  • HHS | National Institutes of Health (NIH)

    R01 NS110550

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  • You are viewing the most recent version of this article.
  • previous version (June 16, 2023).

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Article usage: June 2023 to November 2025

AbstractFullPdf
Jun 202337110697
Jul 20239227480
Aug 20232410347
Sep 2023169823
Oct 20231910031
Nov 2023911545
Dec 20231413122
Total 2023545927345
Jan 20241510724
Feb 2024149826
Mar 202479020
Apr 202498728
May 20241110138
Jun 202489029
Jul 202449925
Aug 2024912152
Sep 202469127
Oct 2024211228
Nov 2024610425
Dec 202488615
Total 2024991186337
Jan 202569914
Feb 2025210112
Mar 2025914227
Apr 2025411737
May 2025311615
Jun 20251112316
Jul 20251210937
Aug 2025812428
Sep 2025819419
Oct 20251112416
Nov 20251318
Total 2025751280229
Total7193393911
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Spinal Sensorimotor Circuits Play a Prominent Role in Hindlimb Locomotor Recovery after Staggered Thoracic Lateral Hemisections but Cannot Restore Posture and Interlimb Coordination during Quadrupedal Locomotion in Adult Cats
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Spinal Sensorimotor Circuits Play a Prominent Role in Hindlimb Locomotor Recovery after Staggered Thoracic Lateral Hemisections but Cannot Restore Posture and Interlimb Coordination during Quadrupedal Locomotion in Adult Cats
Johannie Audet, Sirine Yassine, Charly G. Lecomte, Stephen Mari, Félix Soucy, Caroline Morency, Angèle N. Merlet, Jonathan Harnie, Claudie Beaulieu, Louis Gendron, Ilya A. Rybak, Boris I. Prilutsky, Alain Frigon
eNeuro 16 June 2023, 10 (6) ENEURO.0191-23.2023; DOI: 10.1523/ENEURO.0191-23.2023

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Spinal Sensorimotor Circuits Play a Prominent Role in Hindlimb Locomotor Recovery after Staggered Thoracic Lateral Hemisections but Cannot Restore Posture and Interlimb Coordination during Quadrupedal Locomotion in Adult Cats
Johannie Audet, Sirine Yassine, Charly G. Lecomte, Stephen Mari, Félix Soucy, Caroline Morency, Angèle N. Merlet, Jonathan Harnie, Claudie Beaulieu, Louis Gendron, Ilya A. Rybak, Boris I. Prilutsky, Alain Frigon
eNeuro 16 June 2023, 10 (6) ENEURO.0191-23.2023; DOI: 10.1523/ENEURO.0191-23.2023
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Keywords

  • cat
  • central pattern generator
  • interlimb coordination
  • locomotion
  • spinal cord injury

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