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Research ArticleResearch Article: New Research, Sensory and Motor Systems

Impaired Speaking-Induced Suppression in Alzheimer’s Disease

Kyunghee X. Kim, Corby L. Dale, Kamalini G. Ranasinghe, Hardik Kothare, Alexander J. Beagle, Hannah Lerner, Danielle Mizuiri, Maria Luisa Gorno-Tempini, Keith Vossel, Srikantan S. Nagarajan and John F. Houde
eNeuro 23 May 2023, 10 (6) ENEURO.0056-23.2023; DOI: https://doi.org/10.1523/ENEURO.0056-23.2023
Kyunghee X. Kim
1Department of Otolaryngology−Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94117
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Corby L. Dale
2Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94117
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  • ORCID record for Corby L. Dale
Kamalini G. Ranasinghe
3Department of Neurology, University of California San Francisco, San Francisco, CA 94158
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Hardik Kothare
2Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94117
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Alexander J. Beagle
3Department of Neurology, University of California San Francisco, San Francisco, CA 94158
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Hannah Lerner
3Department of Neurology, University of California San Francisco, San Francisco, CA 94158
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Danielle Mizuiri
2Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94117
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Maria Luisa Gorno-Tempini
3Department of Neurology, University of California San Francisco, San Francisco, CA 94158
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Keith Vossel
3Department of Neurology, University of California San Francisco, San Francisco, CA 94158
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Srikantan S. Nagarajan
2Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94117
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John F. Houde
1Department of Otolaryngology−Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94117
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0056-23.2023
PubMed 
37221089
Published By 
Society for Neuroscience
History 
  • Received February 17, 2023
  • Accepted April 4, 2023
  • Published online May 23, 2023.
Copyright & Usage 
Copyright © 2023 Kim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Kyunghee X. Kim1,
  2. Corby L. Dale2,
  3. Kamalini G. Ranasinghe3,
  4. Hardik Kothare2,
  5. Alexander J. Beagle3,
  6. Hannah Lerner3,
  7. Danielle Mizuiri2,
  8. Maria Luisa Gorno-Tempini3,
  9. Keith Vossel3,
  10. Srikantan S. Nagarajan2 and
  11. John F. Houde1
  1. 1Department of Otolaryngology−Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94117
  2. 2Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94117
  3. 3Department of Neurology, University of California San Francisco, San Francisco, CA 94158
  1. Correspondence should be addressed to Kyunghee X. Kim at kyunghee.kim{at}ucsf.edu or John F. Houde at john.houde{at}ucsf.edu or Srikantan S. Nagarajan at Srikantan.Nagarajan{at}ucsf.edu.
  • K. Vossel’s present address: Mary S. Easton Center for Alzheimer’s Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095.

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Author contributions

  1. Author contributions: S.S.N. and J.F.H. designed research; K.G.R., H.K., A.J.B., H.L., D.M., M.L.G.-T., and K.V. performed research; K.X.K., C.L.D., S.S.N., and J.F.H. analyzed data; K.X.K., C.L.D., S.S.N., and J.F.H. wrote the paper.

  • K. Vossel’s present address: Mary S. Easton Center for Alzheimer’s Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health Grants R01DC017696 (to J.F.H. and S.S.N.), 3R01DC017696-01S1 (to J.F.H. and S.S.N.), R01DC017091 (to J.F.H. and S.S.N.), R01DC010145 (to J.F.H.), R21NS076171 (to S.S.N.), R01NS100440 (to J.F.H., S.S.N., and M.L.G.-T.), R01EB022717 (to S.S.N.), F32AG050434-01A1 (to K.G.R.), K08AG058749 (to K.G.R.), and K23AG038357 (to K.V.); the National Science Foundation Grant BCS-1262297 (to S.S.N. and J.F.H.); a grant from John Douglas French Alzheimer’s Foundation (to K.V.); the Larry L. Hillblom Foundation Grant 2015-A-034-FEL (to K.G.R); a University of California San Francisco Alzheimer’s Disease Research Center pilot project grant (to K.V); grants from the Alzheimer’s Association, and made possible by Part the Cloud: PCTRB-13-288476 (to K.V.) and ETAC-09-133596 (to J.F.H.); a gift from Ricoh Inc. (to S.S.N.); and a gift from the S.D. Bechtel Jr. Foundation (to K.V.).

Funding

  • the National Institute of Health

    R01DC017696; 3R01DC017696-01S1; R01DC017091; R01DC010145; R21NS076171; R01NS100440; R01EB022717; F32AG050434-01A1; K08AG058749; K23AG038357
  • National Science Foundation (NSF)

    BCS-1262297
  • John Douglas French Alzheimer's Foundation (JDFAF)

  • Larry L. Hillblom Foundation (LLHF)

  • University of California San Francisco Alzheimer's Disease Research Center pilot project grant

  • Alzheimer's Association, and made possible by Part the Cloud

    PCTRB-13-288476; ETAC-09-133596
  • Ricoh Inc

  • S.D. Bechtel Jr Foundation

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Impaired Speaking-Induced Suppression in Alzheimer’s Disease
Kyunghee X. Kim, Corby L. Dale, Kamalini G. Ranasinghe, Hardik Kothare, Alexander J. Beagle, Hannah Lerner, Danielle Mizuiri, Maria Luisa Gorno-Tempini, Keith Vossel, Srikantan S. Nagarajan, John F. Houde
eNeuro 23 May 2023, 10 (6) ENEURO.0056-23.2023; DOI: 10.1523/ENEURO.0056-23.2023

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Impaired Speaking-Induced Suppression in Alzheimer’s Disease
Kyunghee X. Kim, Corby L. Dale, Kamalini G. Ranasinghe, Hardik Kothare, Alexander J. Beagle, Hannah Lerner, Danielle Mizuiri, Maria Luisa Gorno-Tempini, Keith Vossel, Srikantan S. Nagarajan, John F. Houde
eNeuro 23 May 2023, 10 (6) ENEURO.0056-23.2023; DOI: 10.1523/ENEURO.0056-23.2023
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Keywords

  • speaking-induced suppression
  • Alzheimer’s disease
  • state feedback control model
  • efference copy
  • magnetoencephalography

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