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Research ArticleResearch Article: New Research, Sensory and Motor Systems

Aβ-CT Affective Touch: Touch Pleasantness Ratings for Gentle Stroking and Deep Pressure Exhibit Dependence on A-Fibers

Laura K. Case, Nicholas Madian, Micaela V. McCall, Megan L. Bradson, Jaquette Liljencrantz, Benjamin Goldstein, Vincent J. Alasha and Marisa S. Zimmerman
eNeuro 11 May 2023, 10 (5) ENEURO.0504-22.2023; https://doi.org/10.1523/ENEURO.0504-22.2023
Laura K. Case
1Department of Anesthesiology, University of California San Diego School of Medicine, San Diego, CA 92037
2National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD 20892
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Nicholas Madian
2National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD 20892
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Micaela V. McCall
2National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD 20892
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Megan L. Bradson
2National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD 20892
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Jaquette Liljencrantz
2National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD 20892
3Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden
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Benjamin Goldstein
1Department of Anesthesiology, University of California San Diego School of Medicine, San Diego, CA 92037
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Vincent J. Alasha
1Department of Anesthesiology, University of California San Diego School of Medicine, San Diego, CA 92037
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Marisa S. Zimmerman
1Department of Anesthesiology, University of California San Diego School of Medicine, San Diego, CA 92037
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    Figure 1.

    Somatosensory stimuli administered during ischemic compression nerve block. A, Gentle brushing was administered with at a rate of 3 cm/s using a soft goat hair watercolor brush. B, Deep pressure was administered using a commercially available hand massager. C, Vibration sensation was tested using a custom vibration device at 200 Hz. D, Perception of warmth was tested using a Medoc thermode.

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    Figure 2.

    Somatosensory stimuli administered during nerve compression block. A, Gentle brushing was administered with at a rate of 3 cm/s using a soft goat hair watercolor brush. B, Deep pressure was administered using a commercially available hand massager. C, Vibration sensation was tested using a custom vibration device at 200 Hz. D, Perception of cold and warmth were tested using a QST.Lab T09 thermode.

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    Figure 3.

    Effect of afferent A-fiber block on intensity and pleasantness of gentle brushing. The intensity and pleasantness of slow gentle brushing on the hand or arm was rated after ischemic or compression nerve block, on sufficient loss of A-fiber associated sensation. Participants who met all preestablished criteria for nerve fiber separation and maintained the criteria after affective testing are labeled “full responders”; participants whose warmth perception rose >1°C or who did not maintain all criteria directly after the brushing task are labeled “partial responders.” For pleasantness ratings, negative numbers indicate unpleasantness.

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    Figure 4.

    Effect of afferent A-fiber block on intensity and pleasantness of deep pressure. The intensity and pleasantness of deep pressure was rated after ischemic or compression nerve block, on sufficient loss of A-fiber associated sensation. Participants who met all preestablished criteria for nerve fiber separation and maintained the criteria after affective testing are labeled “full responders”; participants whose warmth perception rose >1°C or who did not maintain all criteria directly after the brushing task are labeled “partial responders.” For pleasantness ratings, negative numbers indicate unpleasantness.

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    Table 1

    Statistical table

    Data structureType of testPower/Effect size
    aNon-normalLinear mixed effects modelCohen’s d = 0.55
    bNon-normalLinear mixed effects modelCohen’s d = 0.91
    cNon-normalLinear mixed effects modelCohen’s d = 1.6
    dNon-normalLinear mixed effects modelCohen’s d = 1.7
    eNon-normalLinear mixed effects modelCohen’s d = 1.35
    fNon-normalLinear mixed effects modelCohen’s d = 1.92
    gNon-normalLinear mixed effects modelCohen’s d = 1.33
    hNon-normalLinear mixed effects modelCohen’s d = 1.92
    iNon-normalPearson’s correlation
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eneuro: 10 (5)
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May 2023
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Aβ-CT Affective Touch: Touch Pleasantness Ratings for Gentle Stroking and Deep Pressure Exhibit Dependence on A-Fibers
Laura K. Case, Nicholas Madian, Micaela V. McCall, Megan L. Bradson, Jaquette Liljencrantz, Benjamin Goldstein, Vincent J. Alasha, Marisa S. Zimmerman
eNeuro 11 May 2023, 10 (5) ENEURO.0504-22.2023; DOI: 10.1523/ENEURO.0504-22.2023

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Aβ-CT Affective Touch: Touch Pleasantness Ratings for Gentle Stroking and Deep Pressure Exhibit Dependence on A-Fibers
Laura K. Case, Nicholas Madian, Micaela V. McCall, Megan L. Bradson, Jaquette Liljencrantz, Benjamin Goldstein, Vincent J. Alasha, Marisa S. Zimmerman
eNeuro 11 May 2023, 10 (5) ENEURO.0504-22.2023; DOI: 10.1523/ENEURO.0504-22.2023
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Keywords

  • affective touch
  • C-tactile
  • pleasant touch
  • sensory afferents

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