Article Figures & Data
Tables
LMW tau Big tau Exon structure No 4a 4a (250 aa), 4a-L
(355 aa)Alternative splicing 2, 3, 10 2, 3 (10?) Protein size (kDa) 45–60 90–110 Developmental
expressionEmbryonic to adult
Change from 3R to 4RPostnatal/adult
4RDistribution Most of CNS neurons
Non-neuronal cellsPNS neurons
Selective CNS
regionsFunction MT dynamics,
Axonal transport
PlasticityMostly unknown
Stability?Pathology Tauopathies None or slow Therapeutics Antibodies, knockdown Protective? 3R, 4R, MTBD exon 10.







