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Research ArticleOpinion, Development

Big Tau: What We Know, and We Need to Know

Itzhak Fischer
eNeuro 10 May 2023, 10 (5) ENEURO.0052-23.2023; https://doi.org/10.1523/ENEURO.0052-23.2023
Itzhak Fischer
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129
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    Table 1

    Comparing LMW tau to Big tau

    LMW tauBig tau
    Exon structureNo 4a4a (250 aa), 4a-L
    (355 aa)
    Alternative splicing2, 3, 102, 3 (10?)
    Protein size (kDa)45–6090–110
    Developmental
    expression
    Embryonic to adult
    Change from 3R to 4R
    Postnatal/adult
    4R
    DistributionMost of CNS neurons
    Non-neuronal cells
    PNS neurons
    Selective CNS
    regions
    FunctionMT dynamics,
    Axonal transport
    Plasticity
    Mostly unknown
    Stability?
    PathologyTauopathiesNone or slow
    TherapeuticsAntibodies, knockdownProtective?
    • 3R, 4R, MTBD exon 10.

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eneuro: 10 (5)
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May 2023
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Big Tau: What We Know, and We Need to Know
Itzhak Fischer
eNeuro 10 May 2023, 10 (5) ENEURO.0052-23.2023; DOI: 10.1523/ENEURO.0052-23.2023

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Big Tau: What We Know, and We Need to Know
Itzhak Fischer
eNeuro 10 May 2023, 10 (5) ENEURO.0052-23.2023; DOI: 10.1523/ENEURO.0052-23.2023
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Keywords

  • cytoskeleton
  • development
  • microtubules
  • PNS
  • regeneration
  • tauopathies

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