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Research ArticleResearch Article: New Research, Cognition and Behavior

The Genetic Architectures of Functional and Structural Connectivity Properties within Cerebral Resting-State Networks

Elleke Tissink, Josefin Werme, Siemon C. de Lange, Jeanne E. Savage, Yongbin Wei, Christiaan A. de Leeuw, Mats Nagel, Danielle Posthuma and Martijn P. van den Heuvel
eNeuro 7 March 2023, 10 (4) ENEURO.0242-22.2023; https://doi.org/10.1523/ENEURO.0242-22.2023
Elleke Tissink
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam 1081 HV, The Netherlands
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  • ORCID record for Elleke Tissink
Josefin Werme
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam 1081 HV, The Netherlands
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Siemon C. de Lange
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam 1081 HV, The Netherlands
2Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam 1105 BA, The Netherlands
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Jeanne E. Savage
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam 1081 HV, The Netherlands
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Yongbin Wei
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam 1081 HV, The Netherlands
3School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing 100876, China
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Christiaan A. de Leeuw
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam 1081 HV, The Netherlands
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Mats Nagel
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam 1081 HV, The Netherlands
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Danielle Posthuma
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam 1081 HV, The Netherlands
4Department of Clinical Genetics, Section Complex Trait Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam University Medical Centre, Amsterdam 1081 HZ, The Netherlands
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Martijn P. van den Heuvel
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam 1081 HV, The Netherlands
4Department of Clinical Genetics, Section Complex Trait Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam University Medical Centre, Amsterdam 1081 HZ, The Netherlands
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0242-22.2023
PubMed 
36882310
Published By 
Society for Neuroscience
History 
  • Received June 23, 2022
  • Revision received December 12, 2022
  • Accepted January 8, 2023
  • Published online March 7, 2023.
Copyright & Usage 
Copyright © 2023 Tissink et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Elleke Tissink1,
  2. Josefin Werme1,
  3. Siemon C. de Lange1,2,
  4. Jeanne E. Savage1,
  5. Yongbin Wei1,3,
  6. Christiaan A. de Leeuw1,
  7. Mats Nagel1,
  8. Danielle Posthuma1,4 and
  9. Martijn P. van den Heuvel1,4
  1. 1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam 1081 HV, The Netherlands
  2. 2Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam 1105 BA, The Netherlands
  3. 3School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing 100876, China
  4. 4Department of Clinical Genetics, Section Complex Trait Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam University Medical Centre, Amsterdam 1081 HZ, The Netherlands
  1. Correspondence should be addressed to Martijn van den Heuvel at martijn.vanden.heuvel{at}vu.nl.
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Author contributions

  1. Author contributions: E.T., J.W., C.A.d.L., D.P., and M.P.v.d.H. designed research; E.T., S.C.d.L., J.E.S., Y.W., and M.N. performed research; E.T. and J.W. analyzed data; E.T., J.W., S.C.d.L., J.E.S., Y.W., C.A.d.L., M.N., D.P., and M.P.v.d.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • D.P. was supported by The Netherlands Organization for Scientific Research (NWO) Grant VICI 453-14-005, the NWO Gravitation: BRAINSCAPES: A Roadmap from Neurogenetics to Neurobiology Grant No. 024.004.012, and the European Research Council (ERC) Advanced Grant No. ERC-2018-AdG GWAS2FUNC 834057. The work of S.C.d.L. was supported by the ZonMw Open Competition Project REMOVE 09120011910032. C.A.d.L. is supported by Hoffman-La Roche. M.P.v.d.H. was supported by NWO VIDI Grant 452-16-015 and the ERC Consolidator of the European Research Council Grant 101001062. J.E.S. was supported by the NWO VENI Grant 201G-064.

Funding

  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)

    VICI 453-14-005; Gravitation 024.004.012; VIDI 452-16-015; VENI 201G-064
  • EC | European Research Council (ERC)

    ERC-2018-AdG GWAS2FUNC 834057; 101001062
  • ZonMw (Netherlands Organisation for Health Research and Development)

    REMOVE 09120011910032
  • Hoffman-La Roche

Other Version

  • You are viewing the most recent version of this article.
  • previous version (March 07, 2023).

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AbstractFullPdf
Mar 20233770113
Apr 2023142264123
May 20234015966
Jun 20233919658
Jul 20233820874
Aug 20232425875
Sep 20232250038
Oct 20231931640
Nov 20232419938
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Jan 20251912236
Feb 20251415133
Mar 20252714232
Apr 20251813333
May 20251412614
Jun 20251913237
Jul 20251215141
Aug 20251112073
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Total 20252131935471
Jan 202666311
Total 202666311
Total123561471619
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April 2023
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The Genetic Architectures of Functional and Structural Connectivity Properties within Cerebral Resting-State Networks
Elleke Tissink, Josefin Werme, Siemon C. de Lange, Jeanne E. Savage, Yongbin Wei, Christiaan A. de Leeuw, Mats Nagel, Danielle Posthuma, Martijn P. van den Heuvel
eNeuro 7 March 2023, 10 (4) ENEURO.0242-22.2023; DOI: 10.1523/ENEURO.0242-22.2023

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The Genetic Architectures of Functional and Structural Connectivity Properties within Cerebral Resting-State Networks
Elleke Tissink, Josefin Werme, Siemon C. de Lange, Jeanne E. Savage, Yongbin Wei, Christiaan A. de Leeuw, Mats Nagel, Danielle Posthuma, Martijn P. van den Heuvel
eNeuro 7 March 2023, 10 (4) ENEURO.0242-22.2023; DOI: 10.1523/ENEURO.0242-22.2023
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Keywords

  • connectivity
  • GWAS
  • networks
  • neuroimaging
  • resting-state
  • structure-function

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