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Research ArticleResearch Article: New Research, Neuronal Excitability

Persistent Firing in Hippocampal CA1 Pyramidal Cells in Young and Aged Rats

Yacine Brahimi, Beate Knauer, Alan Tobias Price, Maria Jesus Valero-Aracama, Antonio Reboreda, Magdalena Sauvage and Motoharu Yoshida
eNeuro 9 March 2023, 10 (3) ENEURO.0479-22.2023; https://doi.org/10.1523/ENEURO.0479-22.2023
Yacine Brahimi
1German Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany
2Otto‐von‐Guericke Universität (OvGU), Medical Faculty, Magdeburg 39120, Germany
4Leibniz Institute for Neurobiology (LIN), FAM Dpt, Magdeburg 39118, Germany
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  • ORCID record for Yacine Brahimi
Beate Knauer
3International Graduate School of Neuroscience (IGSN), Ruhr University Bochum (RUB), Bochum 44801, Germany
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Alan Tobias Price
1German Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany
2Otto‐von‐Guericke Universität (OvGU), Medical Faculty, Magdeburg 39120, Germany
4Leibniz Institute for Neurobiology (LIN), FAM Dpt, Magdeburg 39118, Germany
5Center for Behavioral Brain Sciences (CBBS), Magdeburg 39106, Germany
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Maria Jesus Valero-Aracama
6Faculty of Psychology, Mercator Research Group-Structure of Memory, Ruhr University Bochum, Bochum 44801, Germany
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Antonio Reboreda
1German Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany
4Leibniz Institute for Neurobiology (LIN), FAM Dpt, Magdeburg 39118, Germany
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Magdalena Sauvage
2Otto‐von‐Guericke Universität (OvGU), Medical Faculty, Magdeburg 39120, Germany
4Leibniz Institute for Neurobiology (LIN), FAM Dpt, Magdeburg 39118, Germany
5Center for Behavioral Brain Sciences (CBBS), Magdeburg 39106, Germany
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Motoharu Yoshida
1German Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany
4Leibniz Institute for Neurobiology (LIN), FAM Dpt, Magdeburg 39118, Germany
5Center for Behavioral Brain Sciences (CBBS), Magdeburg 39106, Germany
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0479-22.2023
PubMed 
36894320
Published By 
Society for Neuroscience
History 
  • Received October 29, 2022
  • Revision received February 7, 2023
  • Accepted February 15, 2023
  • Published online March 9, 2023.
Copyright & Usage 
Copyright © 2023 Brahimi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Yacine Brahimi1,2,4,*,
  2. Beate Knauer3,*,
  3. Alan Tobias Price1,2,4,5,
  4. Maria Jesus Valero-Aracama6,
  5. Antonio Reboreda1,4,
  6. Magdalena Sauvage2,4,5 and
  7. Motoharu Yoshida1,4,5
  1. 1German Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany
  2. 2Otto‐von‐Guericke Universität (OvGU), Medical Faculty, Magdeburg 39120, Germany
  3. 3International Graduate School of Neuroscience (IGSN), Ruhr University Bochum (RUB), Bochum 44801, Germany
  4. 4Leibniz Institute for Neurobiology (LIN), FAM Dpt, Magdeburg 39118, Germany
  5. 5Center for Behavioral Brain Sciences (CBBS), Magdeburg 39106, Germany
  6. 6Faculty of Psychology, Mercator Research Group-Structure of Memory, Ruhr University Bochum, Bochum 44801, Germany
  1. Correspondence should be addressed to Motoharu Yoshida at motoharu.yoshida{at}lin%E2%80%90magdeburg.de.
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Author contributions

  1. Author contributions: B.K., M.J.V.A., A.R., M.S., and M.Y. designed research; B.K. and M.J.V.A. performed research; Y.B., B.K., and A.T.P. analyzed data; Y.B., B.K., A.T.P., A.R., and M.Y. wrote the paper.

  2. ↵* Y.B. and B.K. contributed equally to this work.

  3. B. Knauer’s present address: Technische Universität Dresden, Center for Regenerative Therapies Dresden (CRTD), Dresden 01307, Germany.

  4. M.J. Valero-Aracama’s present address: Institute of Physiology and Pathophysiology, University of Erlangen-Nürnberg, Erlangen 91054, Germany.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the International Graduate School of Neuroscience at Ruhr University Bochum, the Wilhelm und Günter Esser Foundation (B.K.), Rektorat Program at Ruhr University Bochum (M.Y.) and Deutsche Forschungsgemeinschaft Projects YO177/4-1 and YO177/4-3 (to M.Y.).

Funding

  • Deutsche Forschungsgemeinschaft (DFG)

    YO177/4-1; YO177/4-3

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  • You are viewing the most recent version of this article.
  • previous version (March 09, 2023).

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eneuro: 10 (3)
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Persistent Firing in Hippocampal CA1 Pyramidal Cells in Young and Aged Rats
Yacine Brahimi, Beate Knauer, Alan Tobias Price, Maria Jesus Valero-Aracama, Antonio Reboreda, Magdalena Sauvage, Motoharu Yoshida
eNeuro 9 March 2023, 10 (3) ENEURO.0479-22.2023; DOI: 10.1523/ENEURO.0479-22.2023

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Persistent Firing in Hippocampal CA1 Pyramidal Cells in Young and Aged Rats
Yacine Brahimi, Beate Knauer, Alan Tobias Price, Maria Jesus Valero-Aracama, Antonio Reboreda, Magdalena Sauvage, Motoharu Yoshida
eNeuro 9 March 2023, 10 (3) ENEURO.0479-22.2023; DOI: 10.1523/ENEURO.0479-22.2023
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Keywords

  • afterhyperpolarization
  • aged rats
  • cholinergic agonist
  • depolarization current
  • hippocampus
  • persistent firing

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