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Research ArticleResearch Article: New Research, Sensory and Motor Systems

Pregabalin Silences Oxaliplatin-Activated Sensory Neurons to Relieve Cold Allodynia

Federico Iseppon, Ana P. Luiz, John E. Linley and John N. Wood
eNeuro 31 January 2023, 10 (2) ENEURO.0395-22.2022; https://doi.org/10.1523/ENEURO.0395-22.2022
Federico Iseppon
1Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
2Discovery UK, Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge CB21 6GH, United Kingdom
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Ana P. Luiz
1Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
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John E. Linley
2Discovery UK, Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge CB21 6GH, United Kingdom
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John N. Wood
1Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0395-22.2022
PubMed 
36720644
Published By 
Society for Neuroscience
History 
  • Received September 20, 2022
  • Revision received December 5, 2022
  • Accepted December 30, 2022
  • Published online January 31, 2023.
Copyright & Usage 
Copyright © 2023 Iseppon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Federico Iseppon1,2,
  2. Ana P. Luiz1,
  3. John E. Linley2 and
  4. John N. Wood1
  1. 1Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
  2. 2Discovery UK, Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Cambridge CB21 6GH, United Kingdom
  1. Correspondence should be addressed to John N. Wood at j.wood{at}ucl.ac.uk.
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Author contributions

  1. Author contributions: F.I., J.E.L., and J.N.W. designed research; F.I. and A.P.L. performed research; J.E.L. contributed unpublished reagents/analytic tools; F.I. analyzed data; F.I. and J.N.W. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the AstraZeneca Grant 543105 (to F.I., J.E.L., and J.N.W.), the Wellcome Grant 200183/Z/15/Z (to J.N.W.), the Versus Arthritis Grant 548403 (to A.P.L., F.I., and J.N.W.), and Cancer Research UK Grant 185341 (to J.N.W.).

Funding

  • astra zeneca

    543105
  • Wellcome

    200183/Z/15/Z
  • Versus Arthritis

    548403
  • Cancer Research UK (CRUK)

    185341

Other Version

  • You are viewing the most recent version of this article.
  • previous version (January 31, 2023).

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Pregabalin Silences Oxaliplatin-Activated Sensory Neurons to Relieve Cold Allodynia
Federico Iseppon, Ana P. Luiz, John E. Linley, John N. Wood
eNeuro 31 January 2023, 10 (2) ENEURO.0395-22.2022; DOI: 10.1523/ENEURO.0395-22.2022

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Pregabalin Silences Oxaliplatin-Activated Sensory Neurons to Relieve Cold Allodynia
Federico Iseppon, Ana P. Luiz, John E. Linley, John N. Wood
eNeuro 31 January 2023, 10 (2) ENEURO.0395-22.2022; DOI: 10.1523/ENEURO.0395-22.2022
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Keywords

  • oxaliplatin
  • pain
  • pregabalin
  • sensory neurons
  • silent nociceptors

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