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Research ArticleResearch Article: New Research, Cognition and Behavior

Goal-Directed Action Is Initially Impaired in a hAPP-J20 Mouse Model of Alzheimer’s Disease

Amolika Dhungana, Serena Becchi, Jessica Leake, Gary Morris, Nesli Avgan, Bernard W. Balleine, Bryce Vissel and Laura A. Bradfield
eNeuro 17 January 2023, 10 (2) ENEURO.0363-22.2023; https://doi.org/10.1523/ENEURO.0363-22.2023
Amolika Dhungana
1School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales 2007, Australia
2Centre for Neuroscience and Regenerative Medicine, St. Vincent’s Centre for Applied Medical Research, St. Vincent’s Health Network, Sydney, New South Wales 2010, Australia
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Serena Becchi
3School of Psychology, University of New South Wales Sydney, Sydney, New South Wales 2052, Australia
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Jessica Leake
1School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales 2007, Australia
2Centre for Neuroscience and Regenerative Medicine, St. Vincent’s Centre for Applied Medical Research, St. Vincent’s Health Network, Sydney, New South Wales 2010, Australia
3School of Psychology, University of New South Wales Sydney, Sydney, New South Wales 2052, Australia
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Gary Morris
1School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales 2007, Australia
2Centre for Neuroscience and Regenerative Medicine, St. Vincent’s Centre for Applied Medical Research, St. Vincent’s Health Network, Sydney, New South Wales 2010, Australia
4Tasmanian School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania 7000, Australia
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Nesli Avgan
2Centre for Neuroscience and Regenerative Medicine, St. Vincent’s Centre for Applied Medical Research, St. Vincent’s Health Network, Sydney, New South Wales 2010, Australia
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Bernard W. Balleine
5Decision Neuroscience Laboratory, School of Psychology, University of New South Wales Sydney, Sydney, New South Wales 2052, Australia
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  • ORCID record for Bernard W. Balleine
Bryce Vissel
2Centre for Neuroscience and Regenerative Medicine, St. Vincent’s Centre for Applied Medical Research, St. Vincent’s Health Network, Sydney, New South Wales 2010, Australia
6School of Clinical Medicine, University of New South Wales Medicine & Health, St Vincent’s Healthcare Clinical Campus, Faculty of Medicine and Health, University of New South Wales Sydney, Sydney, New South Wales 2052, Australia
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Laura A. Bradfield
1School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales 2007, Australia
2Centre for Neuroscience and Regenerative Medicine, St. Vincent’s Centre for Applied Medical Research, St. Vincent’s Health Network, Sydney, New South Wales 2010, Australia
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0363-22.2023
PubMed 
36650070
Published By 
Society for Neuroscience
History 
  • Received September 8, 2022
  • Revision received December 12, 2022
  • Accepted January 3, 2023
  • Published online January 17, 2023.
Copyright & Usage 
Copyright © 2023 Dhungana et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Amolika Dhungana1,2,
  2. Serena Becchi3,
  3. Jessica Leake1,2,3,
  4. Gary Morris1,2,4,
  5. Nesli Avgan2,
  6. Bernard W. Balleine5,
  7. Bryce Vissel2,6,* and
  8. Laura A. Bradfield1,2,*
  1. 1School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales 2007, Australia
  2. 2Centre for Neuroscience and Regenerative Medicine, St. Vincent’s Centre for Applied Medical Research, St. Vincent’s Health Network, Sydney, New South Wales 2010, Australia
  3. 3School of Psychology, University of New South Wales Sydney, Sydney, New South Wales 2052, Australia
  4. 4Tasmanian School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania 7000, Australia
  5. 5Decision Neuroscience Laboratory, School of Psychology, University of New South Wales Sydney, Sydney, New South Wales 2052, Australia
  6. 6School of Clinical Medicine, University of New South Wales Medicine & Health, St Vincent’s Healthcare Clinical Campus, Faculty of Medicine and Health, University of New South Wales Sydney, Sydney, New South Wales 2052, Australia
  1. Correspondence should be addressed to Laura A. Bradfield at laura.bradfield{at}uts.edu.au or Bryce Vissel at brycevissel{at}gmail.com.
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Author contributions

  1. Author contributions: S.B., G.M., B.W.B., B.V., and L.A.B. designed research; A.D., S.B., J.L., and L.A.B. performed research; B.V. and L.A.B. contributed unpublished reagents/analytic tools; A.D., S.B., N.A., and L.A.B. analyzed data; A.D., S.B., J.L., G.M., N.A., B.W.B., B.V., and L.A.B. wrote the paper.

  2. ↵* B.V. and L.A.B. contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Health and Medical Research Council of Australia Grant GNT2003346 (to L.A.B.) and by the Australian Research Council Grant DP200102445 (to L.A.B. and B.V.).

Funding

  • Department of Education and Training | Australian Research Council (ARC)

    DP200102445
  • DHAC | National Health and Medical Research Council (NHMRC)

    GNT2003346

Other Version

  • You are viewing the most recent version of this article.
  • previous version (January 17, 2023).

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Goal-Directed Action Is Initially Impaired in a hAPP-J20 Mouse Model of Alzheimer’s Disease
Amolika Dhungana, Serena Becchi, Jessica Leake, Gary Morris, Nesli Avgan, Bernard W. Balleine, Bryce Vissel, Laura A. Bradfield
eNeuro 17 January 2023, 10 (2) ENEURO.0363-22.2023; DOI: 10.1523/ENEURO.0363-22.2023

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Goal-Directed Action Is Initially Impaired in a hAPP-J20 Mouse Model of Alzheimer’s Disease
Amolika Dhungana, Serena Becchi, Jessica Leake, Gary Morris, Nesli Avgan, Bernard W. Balleine, Bryce Vissel, Laura A. Bradfield
eNeuro 17 January 2023, 10 (2) ENEURO.0363-22.2023; DOI: 10.1523/ENEURO.0363-22.2023
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Keywords

  • Alzheimer’s
  • decision-making
  • goal-directed action
  • hAPP-J20 mice
  • hippocampus
  • neuroinflammation

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