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Research ArticleResearch Article: New Research, Cognition and Behavior

Touchscreen-Based Cognitive Training Alters Functional Connectivity Patterns in Aged But Not Young Male Rats

Leslie S. Gaynor, Meena Ravi, Sabrina Zequeira, Andreina M. Hampton, Wonn S. Pyon, Samantha Smith, Luis M. Colon-Perez, Marjory Pompilus, Jennifer L. Bizon, Andrew P. Maurer, Marcelo Febo and Sara N. Burke
eNeuro 8 February 2023, 10 (2) ENEURO.0329-22.2023; https://doi.org/10.1523/ENEURO.0329-22.2023
Leslie S. Gaynor
1Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158
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Meena Ravi
2Department of Neuroscience, University of Florida, Gainesville, FL 32610
4McKnight Brain Institute and College of Medicine, University of Florida, Gainesville, FL 32610
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Sabrina Zequeira
2Department of Neuroscience, University of Florida, Gainesville, FL 32610
4McKnight Brain Institute and College of Medicine, University of Florida, Gainesville, FL 32610
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Andreina M. Hampton
2Department of Neuroscience, University of Florida, Gainesville, FL 32610
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Wonn S. Pyon
2Department of Neuroscience, University of Florida, Gainesville, FL 32610
4McKnight Brain Institute and College of Medicine, University of Florida, Gainesville, FL 32610
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Samantha Smith
2Department of Neuroscience, University of Florida, Gainesville, FL 32610
4McKnight Brain Institute and College of Medicine, University of Florida, Gainesville, FL 32610
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Luis M. Colon-Perez
5Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107
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Marjory Pompilus
3Department of Psychiatry, University of Florida, Gainesville, FL 32610
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Jennifer L. Bizon
2Department of Neuroscience, University of Florida, Gainesville, FL 32610
4McKnight Brain Institute and College of Medicine, University of Florida, Gainesville, FL 32610
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Andrew P. Maurer
2Department of Neuroscience, University of Florida, Gainesville, FL 32610
4McKnight Brain Institute and College of Medicine, University of Florida, Gainesville, FL 32610
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Marcelo Febo
3Department of Psychiatry, University of Florida, Gainesville, FL 32610
4McKnight Brain Institute and College of Medicine, University of Florida, Gainesville, FL 32610
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Sara N. Burke
2Department of Neuroscience, University of Florida, Gainesville, FL 32610
4McKnight Brain Institute and College of Medicine, University of Florida, Gainesville, FL 32610
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0329-22.2023
PubMed 
36754628
Published By 
Society for Neuroscience
History 
  • Received August 17, 2022
  • Revision received December 31, 2022
  • Accepted January 26, 2023
  • Published online February 8, 2023.
Copyright & Usage 
Copyright © 2023 Gaynor et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Leslie S. Gaynor1,
  2. Meena Ravi2,4,
  3. Sabrina Zequeira2,4,
  4. Andreina M. Hampton2,
  5. Wonn S. Pyon2,4,
  6. Samantha Smith2,4,
  7. Luis M. Colon-Perez5,
  8. Marjory Pompilus3,
  9. Jennifer L. Bizon2,4,
  10. Andrew P. Maurer2,4,
  11. Marcelo Febo3,4 and
  12. Sara N. Burke2,4
  1. 1Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158
  2. 2Department of Neuroscience, University of Florida, Gainesville, FL 32610
  3. 3Department of Psychiatry, University of Florida, Gainesville, FL 32610
  4. 4McKnight Brain Institute and College of Medicine, University of Florida, Gainesville, FL 32610
  5. 5Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107
  1. Correspondence should be addressed to Sara N. Burke at burkes{at}ufl.edu.
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Author contributions

  1. Author contributions: J.L.B., A.P.M., and S.N.B. designed research; L.S.G., M.R., S.Z., A.M.H., M.P., J.L.B., A.P.M., M.F., and S.N.B. performed research; L.S.G., M.R., S.Z., W.S.P., S.S., L.M.C.-P., M.P., M.F., and S.N.B. contributed unpublished reagents/analytic tools; L.S.G., M.R., S.Z., M.P., M.F., and S.B. analyzed data; L.S.G. and S.N.B. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institutes of Health (NIH) National Institute on Aging Grants R01/RF1 AG049722, AG060977, and P50 AG047266 and the McKnight Brain Research Foundation. Research reported in this publication was also supported by the University of Florida Clinical and Translational Science Institute: the NIH Center Grant UL1TR001427. This work was also supported by the Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS) facility (National Science Foundation Cooperative Agreement No. DMR-1157490 and the State of Florida).

Funding

  • HHS | NIH | National Institute on Aging (NIA)

    R01/RF1 AG049722
  • UF | Clinical and Translational Science Institute, University of Florida (CTSI)

    UL1TR001427
  • National Science Foundation Cooperative Agreement and State of Florida

    DMR-1157490

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  • previous version (February 08, 2023).

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Touchscreen-Based Cognitive Training Alters Functional Connectivity Patterns in Aged But Not Young Male Rats
Leslie S. Gaynor, Meena Ravi, Sabrina Zequeira, Andreina M. Hampton, Wonn S. Pyon, Samantha Smith, Luis M. Colon-Perez, Marjory Pompilus, Jennifer L. Bizon, Andrew P. Maurer, Marcelo Febo, Sara N. Burke
eNeuro 8 February 2023, 10 (2) ENEURO.0329-22.2023; DOI: 10.1523/ENEURO.0329-22.2023

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Touchscreen-Based Cognitive Training Alters Functional Connectivity Patterns in Aged But Not Young Male Rats
Leslie S. Gaynor, Meena Ravi, Sabrina Zequeira, Andreina M. Hampton, Wonn S. Pyon, Samantha Smith, Luis M. Colon-Perez, Marjory Pompilus, Jennifer L. Bizon, Andrew P. Maurer, Marcelo Febo, Sara N. Burke
eNeuro 8 February 2023, 10 (2) ENEURO.0329-22.2023; DOI: 10.1523/ENEURO.0329-22.2023
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Keywords

  • associative memory
  • cognitive aging
  • cognitive training
  • functional connectivity
  • graph theory
  • medial temporal lobe

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