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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression

Ricardo Lima-Filho, Juliana S. Fortuna, Danielle Cozachenco, Alinny R. Isaac, Natalia Lyra e Silva, Alice Saldanha, Luis E. Santos, Sergio T. Ferreira, Mychael V. Lourenco and Fernanda G. De Felice
eNeuro 25 January 2023, 10 (2) ENEURO.0256-22.2023; https://doi.org/10.1523/ENEURO.0256-22.2023
Ricardo Lima-Filho
1Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro RJ, Brazil
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  • ORCID record for Ricardo Lima-Filho
Juliana S. Fortuna
2Institute of Biomedical Sciences, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro RJ, Brazil
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Danielle Cozachenco
1Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro RJ, Brazil
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Alinny R. Isaac
1Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro RJ, Brazil
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Natalia Lyra e Silva
4Centre for Neurosciences Studies, Departments of Biomedical and Molecular Sciences, and Psychiatry, Queen’s University, Kingston, Ontario K7L 3N6, Canada
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Alice Saldanha
1Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro RJ, Brazil
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Luis E. Santos
3Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro RJ, Brazil
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Sergio T. Ferreira
1Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro RJ, Brazil
3Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro RJ, Brazil
5D’Or Institute for Research and Education, Rio de Janeiro RJ, 22281-100, Brazil
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Mychael V. Lourenco
1Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro RJ, Brazil
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Fernanda G. De Felice
1Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro RJ, Brazil
4Centre for Neurosciences Studies, Departments of Biomedical and Molecular Sciences, and Psychiatry, Queen’s University, Kingston, Ontario K7L 3N6, Canada
5D’Or Institute for Research and Education, Rio de Janeiro RJ, 22281-100, Brazil
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0256-22.2023
PubMed 
36697257
Published By 
Society for Neuroscience
History 
  • Received June 28, 2022
  • Revision received January 16, 2023
  • Accepted January 19, 2023
  • Published online January 25, 2023.
Copyright & Usage 
Copyright © 2023 Lima-Filho et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ricardo Lima-Filho1,
  2. Juliana S. Fortuna2,
  3. Danielle Cozachenco1,
  4. Alinny R. Isaac1,
  5. Natalia Lyra e Silva4,
  6. Alice Saldanha1,
  7. Luis E. Santos3,
  8. Sergio T. Ferreira1,3,5,
  9. Mychael V. Lourenco1 and
  10. Fernanda G. De Felice1,4,5
  1. 1Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro RJ, Brazil
  2. 2Institute of Biomedical Sciences, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro RJ, Brazil
  3. 3Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro RJ, Brazil
  4. 4Centre for Neurosciences Studies, Departments of Biomedical and Molecular Sciences, and Psychiatry, Queen’s University, Kingston, Ontario K7L 3N6, Canada
  5. 5D’Or Institute for Research and Education, Rio de Janeiro RJ, 22281-100, Brazil
  1. Correspondence should be addressed to Fernanda G. De Felice at fernanda.defelice{at}queensu.ca or Mychael V. Lourenco at mychael{at}bioqmed.ufrj.br.
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Author contributions

  1. Author contributions: R.L.-F., M.V.L., and F.G.D.F. designed research; R.L.-F., J.S.F., D.C., A.R.I., N.L.S., and A.S. performed research; R.L.-F., J.S.F., D.C., A.R.I., A.S., L.E.S., S.T.F., M.V.L., and F.G.D.F. analyzed data; R.L.-F., M.V.L., and F.G.D.F. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by grants from Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ; Grants 202.944/2015 to F.G.D.F.; 202.744/2019 to M.V.L.; and 201.432/2014 to S.T.F.), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; Grants 473324/2013-0 to F.G.D.F., 434093/2018-1 and 311487/2019-0 to M.V.L., and 406436/2016-9 to S.T.F.), National Institute for Translational Neuroscience (INNT/Brazil; to S.T.F. and F.G.D.F.), Alzheimer’s Association (Grant AARG-D-615714 to M.V.L.), and Serrapilheira Institute (Grant R-2012-37967 to M.V.L.). R.L.F. was supported by predoctoral fellowships from CNPq and FAPERJ.

Funding

  • Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)

    202.944/2015; 202.744/2019; 201.432/2014
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

    473324/2013-0; 434093/2018-1; 311487/2019-0; 406436/2016-9
  • Instituto Nacional de Ciência e Tecnologia de Neurociência Translacional (INCT-INNT)

  • Alzheimer's Association (AA)

    AARG-D-615714
  • Instituto Serrapilheira (Serrapilheira Institute)

    R-2012-37967

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Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression
Ricardo Lima-Filho, Juliana S. Fortuna, Danielle Cozachenco, Alinny R. Isaac, Natalia Lyra e Silva, Alice Saldanha, Luis E. Santos, Sergio T. Ferreira, Mychael V. Lourenco, Fernanda G. De Felice
eNeuro 25 January 2023, 10 (2) ENEURO.0256-22.2023; DOI: 10.1523/ENEURO.0256-22.2023

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Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression
Ricardo Lima-Filho, Juliana S. Fortuna, Danielle Cozachenco, Alinny R. Isaac, Natalia Lyra e Silva, Alice Saldanha, Luis E. Santos, Sergio T. Ferreira, Mychael V. Lourenco, Fernanda G. De Felice
eNeuro 25 January 2023, 10 (2) ENEURO.0256-22.2023; DOI: 10.1523/ENEURO.0256-22.2023
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Keywords

  • FNDC5
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