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Research ArticleResearch Article: Negative Results, Cognition and Behavior

Effect of the Matrix Metalloproteinase Inhibitor Doxycycline on Human Trace Fear Memory

Jelena M. Wehrli, Yanfang Xia, Benjamin Offenhammer, Birgit Kleim, Daniel Müller and Dominik R. Bach
eNeuro 9 February 2023, 10 (2) ENEURO.0243-22.2023; https://doi.org/10.1523/ENEURO.0243-22.2023
Jelena M. Wehrli
1Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich 8032, Switzerland
2Experimental Psychopathology and Psychotherapy, Department of Psychology, University of Zurich, Zurich 8050, Switzerland
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Yanfang Xia
1Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich 8032, Switzerland
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Benjamin Offenhammer
1Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich 8032, Switzerland
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Birgit Kleim
1Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich 8032, Switzerland
2Experimental Psychopathology and Psychotherapy, Department of Psychology, University of Zurich, Zurich 8050, Switzerland
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Daniel Müller
3Department of Clinical Chemistry, University Hospital Zurich, University of Zurich, Zurich 8091, Switzerland
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Dominik R. Bach
1Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich 8032, Switzerland
4Wellcome Centre for Human Neuroimaging and Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London WC1B 5EH, United Kingdom
5Hertz Chair for Artificial Intelligence and Neuroscience, Transdisciplinary Research Area “Life and Health,” University of Bonn, Bonn 53121, Germany
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eneuro: 10 (2)
eNeuro
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February 2023
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Effect of the Matrix Metalloproteinase Inhibitor Doxycycline on Human Trace Fear Memory
Jelena M. Wehrli, Yanfang Xia, Benjamin Offenhammer, Birgit Kleim, Daniel Müller, Dominik R. Bach
eNeuro 9 February 2023, 10 (2) ENEURO.0243-22.2023; DOI: 10.1523/ENEURO.0243-22.2023

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Effect of the Matrix Metalloproteinase Inhibitor Doxycycline on Human Trace Fear Memory
Jelena M. Wehrli, Yanfang Xia, Benjamin Offenhammer, Birgit Kleim, Daniel Müller, Dominik R. Bach
eNeuro 9 February 2023, 10 (2) ENEURO.0243-22.2023; DOI: 10.1523/ENEURO.0243-22.2023
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Keywords

  • doxycycline
  • fear conditioning
  • memory modification
  • MMP-9
  • trace fear memory

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