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Research ArticleResearch Article: New Research, History, Teaching, and Public Awareness

Internet-Connected Cortical Organoids for Project-Based Stem Cell and Neuroscience Education

Matthew A. T. Elliott, Hunter E. Schweiger, Ash Robbins, Samira Vera-Choqqueccota, Drew Ehrlich, Sebastian Hernandez, Kateryna Voitiuk, Jinghui Geng, Jess L. Sevetson, Cordero Core, Yohei M. Rosen, Mircea Teodorescu, Nico O. Wagner, David Haussler and Mohammed A. Mostajo-Radji
eNeuro 28 November 2023, 10 (12) ENEURO.0308-23.2023; https://doi.org/10.1523/ENEURO.0308-23.2023
Matthew A. T. Elliott
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060
2Live Cell Biotechnology Discovery Lab, University of California Santa Cruz, Santa Cruz, CA 95060
3Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95060
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Hunter E. Schweiger
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060
2Live Cell Biotechnology Discovery Lab, University of California Santa Cruz, Santa Cruz, CA 95060
4Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95060
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Ash Robbins
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060
2Live Cell Biotechnology Discovery Lab, University of California Santa Cruz, Santa Cruz, CA 95060
5Department of Electrical and Computer Engineering, University of California Santa Cruz, Santa Cruz, CA 95060
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Samira Vera-Choqqueccota
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060
2Live Cell Biotechnology Discovery Lab, University of California Santa Cruz, Santa Cruz, CA 95060
3Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95060
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Drew Ehrlich
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060
2Live Cell Biotechnology Discovery Lab, University of California Santa Cruz, Santa Cruz, CA 95060
6Department of Computational Media, University of California Santa Cruz, Santa Cruz, CA 95060
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Sebastian Hernandez
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060
2Live Cell Biotechnology Discovery Lab, University of California Santa Cruz, Santa Cruz, CA 95060
5Department of Electrical and Computer Engineering, University of California Santa Cruz, Santa Cruz, CA 95060
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Kateryna Voitiuk
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060
2Live Cell Biotechnology Discovery Lab, University of California Santa Cruz, Santa Cruz, CA 95060
3Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95060
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Jinghui Geng
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060
2Live Cell Biotechnology Discovery Lab, University of California Santa Cruz, Santa Cruz, CA 95060
5Department of Electrical and Computer Engineering, University of California Santa Cruz, Santa Cruz, CA 95060
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Jess L. Sevetson
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060
4Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95060
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Cordero Core
7Scientific Software Engineering Center, eScience Institute, University of Washington, Seattle, WA 98195
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Yohei M. Rosen
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060
2Live Cell Biotechnology Discovery Lab, University of California Santa Cruz, Santa Cruz, CA 95060
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Mircea Teodorescu
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060
2Live Cell Biotechnology Discovery Lab, University of California Santa Cruz, Santa Cruz, CA 95060
3Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95060
5Department of Electrical and Computer Engineering, University of California Santa Cruz, Santa Cruz, CA 95060
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Nico O. Wagner
8College of Arts and Sciences, University of San Francisco, San Francisco, CA 94117
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David Haussler
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060
2Live Cell Biotechnology Discovery Lab, University of California Santa Cruz, Santa Cruz, CA 95060
3Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95060
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Mohammed A. Mostajo-Radji
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060
2Live Cell Biotechnology Discovery Lab, University of California Santa Cruz, Santa Cruz, CA 95060
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  • ORCID record for Mohammed A. Mostajo-Radji
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0308-23.2023
PubMed 
38016807
Published By 
Society for Neuroscience
History 
  • Received August 20, 2023
  • Revision received October 16, 2023
  • Accepted November 20, 2023
  • Published online November 28, 2023.
Copyright & Usage 
Copyright © 2023 Elliott et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Matthew A. T. Elliott1,2,3,*,
  2. Hunter E. Schweiger1,2,4,*,
  3. Ash Robbins1,2,5,*,
  4. Samira Vera-Choqqueccota1,2,3,
  5. Drew Ehrlich1,2,6,
  6. Sebastian Hernandez1,2,5,
  7. Kateryna Voitiuk1,2,3,
  8. Jinghui Geng1,2,5,
  9. Jess L. Sevetson1,4,
  10. Cordero Core7,
  11. Yohei M. Rosen1,2,
  12. Mircea Teodorescu1,2,3,5,
  13. Nico O. Wagner8,
  14. David Haussler1,2,3 and
  15. Mohammed A. Mostajo-Radji1,2
  1. 1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95060
  2. 2Live Cell Biotechnology Discovery Lab, University of California Santa Cruz, Santa Cruz, CA 95060
  3. 3Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA 95060
  4. 4Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95060
  5. 5Department of Electrical and Computer Engineering, University of California Santa Cruz, Santa Cruz, CA 95060
  6. 6Department of Computational Media, University of California Santa Cruz, Santa Cruz, CA 95060
  7. 7Scientific Software Engineering Center, eScience Institute, University of Washington, Seattle, WA 98195
  8. 8College of Arts and Sciences, University of San Francisco, San Francisco, CA 94117
  1. Correspondence should be addressed to Mohammed A. Mostajo-Radji at mmostajo{at}ucsc.edu.
View Full Text

Author contributions

  1. Author contributions: M.A.T.E., H.E.S., A.R., N.O.W., D.H., and M.A.M.-R. designed research; M.A.T.E., H.E.S., A.R., S.V.-C., D.E., K.V., J.G., and J.L.S. performed research; D.E., C.C., and Y.M.R. contributed unpublished reagents/analytic tools; M.A.T.E., H.E.S., A.R., and S.H. analyzed data; M.A.T.E., H.E.S., A.R., M.T., N.O.W., D.H., and M.A.M.-R. wrote the paper.

  2. ↵* M.A.T.E., H.E.S., and A.R. contributed equally to this work.

Disclosures

  • M.A.M.-R. is a cofounder of Paika, a company for remote people-to-people interactions. All other authors declare no competing financial interests.

  • This work was supported by the Schmidt Futures Grant SF857 (to M.T. and D.H.); the National Human Genome Research Institute Grant 1RM1HG011543 (to M.T. and D.H.); National Science Foundation Grants NSF2134955 (to M.T. and D.H.) and NSF2034037 (to M.T.); the National Institute of Mental Health Grant 1U24MH132628 (to D.H. and M.A.M.-R.). H.E.S. is a National Science Foundation Graduate Student Research Fellowship grantee. K.V. was supported by the ARCS Foundation and the National Human Genome Research Institute (NHGRI) Grant T32HG012344. J.L.S. was supported by the University of California Santa Cruz Chancellor’s Postdoctoral Fellowship, the National Institutes of Health Grant K12GM139185 (through National Institute of General Medical Sciences to University of California Santa Cruz Institute for the Biology of Stem Cells), and the National Institute of Child Health and Human Development Grant LRP0000018281. We are thankful to the Pacific Research Platform, supported by the National Science Foundation under Award Numbers CNS-1730158, ACI-1540112, ACI-1541349, and OAC-1826967; the University of California Office of the President; and the University of California San Diego’s California Institute for Telecommunications and Information Technology/Qualcomm Institute. Thanks to CENIC for the 100 Gbps networks. This research received software engineering support from the University of Washington’s Scientific Software Engineering Center (SSEC) supported by Schmidt Futures, as part of the Virtual Institute for Scientific Software (VISS).

Funding

  • Schmidt Futures

    SF857
  • HHS | NIH | National Human Genome Research Institute (NHGRI)

    1RM1HG011543
  • National Science Foundation (NSF)

    NSF2134955; NSF2034037
  • HHS | NIH | National Institute of Mental Health (NIMH)

    1U24MH132628

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  • You are viewing the most recent version of this article.
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Internet-Connected Cortical Organoids for Project-Based Stem Cell and Neuroscience Education
Matthew A. T. Elliott, Hunter E. Schweiger, Ash Robbins, Samira Vera-Choqqueccota, Drew Ehrlich, Sebastian Hernandez, Kateryna Voitiuk, Jinghui Geng, Jess L. Sevetson, Cordero Core, Yohei M. Rosen, Mircea Teodorescu, Nico O. Wagner, David Haussler, Mohammed A. Mostajo-Radji
eNeuro 28 November 2023, 10 (12) ENEURO.0308-23.2023; DOI: 10.1523/ENEURO.0308-23.2023

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Internet-Connected Cortical Organoids for Project-Based Stem Cell and Neuroscience Education
Matthew A. T. Elliott, Hunter E. Schweiger, Ash Robbins, Samira Vera-Choqqueccota, Drew Ehrlich, Sebastian Hernandez, Kateryna Voitiuk, Jinghui Geng, Jess L. Sevetson, Cordero Core, Yohei M. Rosen, Mircea Teodorescu, Nico O. Wagner, David Haussler, Mohammed A. Mostajo-Radji
eNeuro 28 November 2023, 10 (12) ENEURO.0308-23.2023; DOI: 10.1523/ENEURO.0308-23.2023
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Keywords

  • brain organoids
  • internet-of-things
  • neuroscience
  • organoids
  • stem cells
  • STEM education

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