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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Elevated Serotonin in Mouse Spinal Dorsal Horn Is Pronociceptive

Nathan Cramer, Yadong Ji, Maureen A. Kane, Nageswara R. Pilli, Alberto Castro, Luca Posa, Gabrielle Van Patten, Radi Masri and Asaf Keller
eNeuro 9 November 2023, 10 (12) ENEURO.0293-23.2023; https://doi.org/10.1523/ENEURO.0293-23.2023
Nathan Cramer
1Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201
4University of Maryland - Medicine Institute for Neuroscience Discovery, University of Maryland School of Medicine, Baltimore, MD 21201
5Center to Advance Chronic Pain Research, University of Maryland School of Medicine, Baltimore, MD 21201
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Yadong Ji
2Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201
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Maureen A. Kane
3Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201
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Nageswara R. Pilli
3Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201
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Alberto Castro
1Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201
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Luca Posa
1Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201
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Gabrielle Van Patten
1Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201
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Radi Masri
1Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201
2Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201
4University of Maryland - Medicine Institute for Neuroscience Discovery, University of Maryland School of Medicine, Baltimore, MD 21201
5Center to Advance Chronic Pain Research, University of Maryland School of Medicine, Baltimore, MD 21201
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Asaf Keller
1Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201
4University of Maryland - Medicine Institute for Neuroscience Discovery, University of Maryland School of Medicine, Baltimore, MD 21201
5Center to Advance Chronic Pain Research, University of Maryland School of Medicine, Baltimore, MD 21201
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0293-23.2023
PubMed 
37945351
Published By 
Society for Neuroscience
History 
  • Received August 5, 2023
  • Revision received October 27, 2023
  • Accepted October 31, 2023
  • Published online November 9, 2023.
Copyright & Usage 
Copyright © 2023 Cramer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Nathan Cramer1,4,5,
  2. Yadong Ji2,
  3. Maureen A. Kane3,
  4. Nageswara R. Pilli3,
  5. Alberto Castro1,
  6. Luca Posa1,
  7. Gabrielle Van Patten1,
  8. Radi Masri1,2,4,5 and
  9. Asaf Keller1,4,5
  1. 1Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201
  2. 2Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201
  3. 3Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201
  4. 4University of Maryland - Medicine Institute for Neuroscience Discovery, University of Maryland School of Medicine, Baltimore, MD 21201
  5. 5Center to Advance Chronic Pain Research, University of Maryland School of Medicine, Baltimore, MD 21201
  1. Correspondence should be addressed to Nathan Cramer at ncramer{at}som.umaryland.edu.
View Full Text

Author contributions

  1. Author contributions: N.C., M.A.K., N.R.P., A.C., L.P., G.V.P., R.M., and A.K. designed research; N.C., Y.J., M.A.K., N.R.P., A.C., L.P., G.V.P., R.M., and A.K. performed research; N.C., Y.J., M.A.K., N.R.P., A.C., L.P., G.V.P., R.M., and A.K. analyzed data; N.C. and A.K. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Institute of Neurological Disorders and Stroke of the National Institutes of Health Grants R01NS127827, R01NS099245 and R01NS069568. Additional support was provided by the University of Maryland School of Pharmacy Mass Spectrometry Center Grant SOP1841-IQB2014.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    R01NS099245; R01NS069568
  • University of Maryland, Baltimore (UMB)

    SOP1841-IQB2014

Other Version

  • You are viewing the most recent version of this article.
  • previous version (November 09, 2023).

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December 2023
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Elevated Serotonin in Mouse Spinal Dorsal Horn Is Pronociceptive
Nathan Cramer, Yadong Ji, Maureen A. Kane, Nageswara R. Pilli, Alberto Castro, Luca Posa, Gabrielle Van Patten, Radi Masri, Asaf Keller
eNeuro 9 November 2023, 10 (12) ENEURO.0293-23.2023; DOI: 10.1523/ENEURO.0293-23.2023

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Elevated Serotonin in Mouse Spinal Dorsal Horn Is Pronociceptive
Nathan Cramer, Yadong Ji, Maureen A. Kane, Nageswara R. Pilli, Alberto Castro, Luca Posa, Gabrielle Van Patten, Radi Masri, Asaf Keller
eNeuro 9 November 2023, 10 (12) ENEURO.0293-23.2023; DOI: 10.1523/ENEURO.0293-23.2023
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Keywords

  • fiber photometry
  • inflammation
  • mechanical allodynia
  • neuropathic pain
  • rostral ventral medulla

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