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Research ArticleResearch Article: New Research, Cognition and Behavior

High-THC Cannabis Smoke Impairs Incidental Memory Capacity in Spontaneous Tests of Novelty Preference for Objects and Odors in Male Rats

Ilne L. Barnard, Timothy J. Onofrychuk, Aaron D. Toderash, Vyom N. Patel, Aiden E. Glass, Jesse C. Adrian, Robert B. Laprairie and John G. Howland
eNeuro 16 November 2023, 10 (12) ENEURO.0115-23.2023; https://doi.org/10.1523/ENEURO.0115-23.2023
Ilne L. Barnard
1Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, S7N5E5, Canada
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Timothy J. Onofrychuk
1Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, S7N5E5, Canada
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Aaron D. Toderash
4Department of Computer Science, University of Saskatchewan, Saskatoon, Saskatchewan, S7N5C9, Canada
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Vyom N. Patel
4Department of Computer Science, University of Saskatchewan, Saskatoon, Saskatchewan, S7N5C9, Canada
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Aiden E. Glass
1Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, S7N5E5, Canada
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Jesse C. Adrian
1Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, S7N5E5, Canada
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Robert B. Laprairie
2College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, S7N5E5, Canada
3Department of Pharmacology, College of Medicine, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada
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John G. Howland
1Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, S7N5E5, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0115-23.2023
PubMed 
37973381
Published By 
Society for Neuroscience
History 
  • Received April 8, 2023
  • Revision received September 19, 2023
  • Accepted October 16, 2023
  • Published online November 16, 2023.
Copyright & Usage 
Copyright © 2023 Barnard et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ilne L. Barnard1,*,
  2. Timothy J. Onofrychuk1,*,
  3. Aaron D. Toderash4,
  4. Vyom N. Patel4,
  5. Aiden E. Glass1,
  6. Jesse C. Adrian1,
  7. Robert B. Laprairie2,3 and
  8. John G. Howland1
  1. 1Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, S7N5E5, Canada
  2. 2College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, S7N5E5, Canada
  3. 3Department of Pharmacology, College of Medicine, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada
  4. 4Department of Computer Science, University of Saskatchewan, Saskatoon, Saskatchewan, S7N5C9, Canada
  1. Correspondence should be addressed to John G. Howland at john.howland{at}usask.ca.
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Author contributions

  1. Author contributions: I.L.B., T.J.O., A.D.T., R.B.L., and J.G.H. designed research; I.L.B., T.J.O., A.E.G., and J.C.A. performed research; I.L.B., T.J.O., A.D.T., V.N.P., A.E.G., J.C.A., and J.G.H. analyzed data; I.L.B., T.J.O., A.D.T., V.N.P., R.B.L., and J.G.H. wrote the paper.

  2. ↵* I.L.B. and T.J.O. contributed equally to this work.

Disclosures

  • R.B.L. is a member of the Scientific Advisory Board for Shackleford Pharma Inc.; however, this company had no input into this research study. All other authors declare no competing financial interests.

  • This work was supported by the University of Saskatchewan College of Medicine and the Natural Sciences and Engineering Research Council of Canada (NSERC; J.G.H.). I.L.B. and T.J.O. were supported by scholarships from NSERC. J.C.A. was supported by the University of Saskatchewan College of Medicine.

Funding

  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)

  • University of Saskatchewan College of Medicine

Other Version

  • You are viewing the most recent version of this article.
  • previous version (November 16, 2023).

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High-THC Cannabis Smoke Impairs Incidental Memory Capacity in Spontaneous Tests of Novelty Preference for Objects and Odors in Male Rats
Ilne L. Barnard, Timothy J. Onofrychuk, Aaron D. Toderash, Vyom N. Patel, Aiden E. Glass, Jesse C. Adrian, Robert B. Laprairie, John G. Howland
eNeuro 16 November 2023, 10 (12) ENEURO.0115-23.2023; DOI: 10.1523/ENEURO.0115-23.2023

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High-THC Cannabis Smoke Impairs Incidental Memory Capacity in Spontaneous Tests of Novelty Preference for Objects and Odors in Male Rats
Ilne L. Barnard, Timothy J. Onofrychuk, Aaron D. Toderash, Vyom N. Patel, Aiden E. Glass, Jesse C. Adrian, Robert B. Laprairie, John G. Howland
eNeuro 16 November 2023, 10 (12) ENEURO.0115-23.2023; DOI: 10.1523/ENEURO.0115-23.2023
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Keywords

  • cannabinoid
  • machine learning
  • recognition memory

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