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Research ArticleResearch Article: Confirmation, Cognition and Behavior

Reduction of BDNF Levels and Biphasic Changes in Glutamate Release in the Prefrontal Cortex Correlate with Susceptibility to Chronic Stress-Induced Anhedonia

Xiao Hu, Hui-Ling Zhao, Nurhumar Kurban, Yu Qin, Xi Chen, Su-Ying Cui and Yong-He Zhang
eNeuro 21 November 2023, 10 (11) ENEURO.0406-23.2023; https://doi.org/10.1523/ENEURO.0406-23.2023
Xiao Hu
Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing 100191, China
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Hui-Ling Zhao
Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing 100191, China
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Nurhumar Kurban
Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing 100191, China
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Yu Qin
Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing 100191, China
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Xi Chen
Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing 100191, China
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Su-Ying Cui
Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing 100191, China
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Yong-He Zhang
Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing 100191, China
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0406-23.2023
PubMed 
37989582
Published By 
Society for Neuroscience
History 
  • Received October 13, 2023
  • Revision received October 17, 2023
  • Accepted October 26, 2023
  • Published online November 21, 2023.
Copyright & Usage 
Copyright © 2023 Hu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Xiao Hu,
  2. Hui-Ling Zhao,
  3. Nurhumar Kurban,
  4. Yu Qin,
  5. Xi Chen,
  6. Su-Ying Cui and
  7. Yong-He Zhang
  1. Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing 100191, China
  1. Correspondence should be addressed to Yong-He Zhang at zhyh{at}hsc.pku.edu.cn or Su-Ying Cui at csy{at}bjmu.edu.cn.
View Full Text

Author contributions

  1. Author contributions: X.H. and H.-L.Z. designed research; X.H., N.K., and Y.Q. performed research; X.H. and X.C. analyzed data; X.H., S.-Y.C., and Y.-H.Z. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by National Natural Science Foundation of China Grants No. 82204363 and 82073829 and the pharmaceutical innovation varieties and platform cultivation projects founded by Beijing Municipal Science and Technology Commission, Administrative Commission of Zhongguancun Science Park Grant No. Z221100007922035.

Funding

  • MOST | National Natural Science Foundation of China (NSFC)

    82204363; 82073829
  • Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park (北京市科学技术委员会)

    Z221100007922035

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eneuro: 10 (11)
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November 2023
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Reduction of BDNF Levels and Biphasic Changes in Glutamate Release in the Prefrontal Cortex Correlate with Susceptibility to Chronic Stress-Induced Anhedonia
Xiao Hu, Hui-Ling Zhao, Nurhumar Kurban, Yu Qin, Xi Chen, Su-Ying Cui, Yong-He Zhang
eNeuro 21 November 2023, 10 (11) ENEURO.0406-23.2023; DOI: 10.1523/ENEURO.0406-23.2023

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Reduction of BDNF Levels and Biphasic Changes in Glutamate Release in the Prefrontal Cortex Correlate with Susceptibility to Chronic Stress-Induced Anhedonia
Xiao Hu, Hui-Ling Zhao, Nurhumar Kurban, Yu Qin, Xi Chen, Su-Ying Cui, Yong-He Zhang
eNeuro 21 November 2023, 10 (11) ENEURO.0406-23.2023; DOI: 10.1523/ENEURO.0406-23.2023
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Keywords

  • anhedonia susceptibility
  • BDNF
  • chronic stress
  • glutamate release
  • ketamine
  • prefrontal cortex

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