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Research ArticleResearch Article: New Research, Cognition and Behavior

Mitochondrial OPA1 Deficiency Is Associated to Reversible Defects in Spatial Memory Related to Adult Neurogenesis in Mice

Trinovita Andraini, Lionel Moulédous, Petnoi Petsophonsakul, Cédrick Florian, Sébastien Gauzin, Marlène Botella-Daloyau, Macarena Arrázola, Kamela Nikolla, Adam Philip, Alice Leydier, Manon Marque, Laetitia Arnauné-Pelloquin, Pascale Belenguer, Claire Rampon and Marie-Christine Miquel
eNeuro 20 October 2023, 10 (11) ENEURO.0073-23.2023; https://doi.org/10.1523/ENEURO.0073-23.2023
Trinovita Andraini
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
2Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
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Lionel Moulédous
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
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Petnoi Petsophonsakul
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
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Cédrick Florian
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
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Sébastien Gauzin
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
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Marlène Botella-Daloyau
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
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Macarena Arrázola
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
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Kamela Nikolla
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
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Adam Philip
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
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Alice Leydier
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
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Manon Marque
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
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Laetitia Arnauné-Pelloquin
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
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Pascale Belenguer
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
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Claire Rampon
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
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Marie-Christine Miquel
1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0073-23.2023
PubMed 
37863658
Published By 
Society for Neuroscience
History 
  • Received March 2, 2023
  • Revision received July 22, 2023
  • Accepted August 1, 2023
  • Published online October 20, 2023.
Copyright & Usage 
Copyright © 2023 Andraini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Trinovita Andraini1,2,
  2. Lionel Moulédous1,
  3. Petnoi Petsophonsakul1,
  4. Cédrick Florian1,
  5. Sébastien Gauzin1,
  6. Marlène Botella-Daloyau1,
  7. Macarena Arrázola1,
  8. Kamela Nikolla1,
  9. Adam Philip1,
  10. Alice Leydier1,
  11. Manon Marque1,
  12. Laetitia Arnauné-Pelloquin1,
  13. Pascale Belenguer1,
  14. Claire Rampon1,* and
  15. Marie-Christine Miquel1,*
  1. 1Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, Centre National de la Recherche Scientifique, Université Toulouse 3, 31400, Toulouse, France
  2. 2Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
  1. Correspondence should be addressed to Marie-Christine Miquel at marie-christine.miquel{at}univ-tlse3.fr.
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Author contributions

  1. Author contributions: C.R. and M.-C.M. designed research; T.A., L.M., P.P., C.F., S.G., M.B., M.-B.D., K.N., A.P., A.L., M.-C.M., M.M., L.A.-P., and P.B. performed research; T.A., L.M., P.P., C.F., S.G., M.-B.D., M.A., K.N., A.P., A.L., M.-C.M., L.A.-P., P.B., C.R., and M.-C.M. analyzed data; C.R. and M.-C.M. wrote the paper.

  2. ↵* C.R. and M.-C.M. share senior authorship and contributed equally to this work.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the Centre National de la Recherche Scientifique, the University of Toulouse, and by Association France Alzheimer, Fédération pour la Recherche sur le Cerveau, and the Directorate General of Higher Education (DGHE) of Indonesia.

Funding

  • Centre National de la Recherche Scientifique (CNRS)

  • University Toulouse 3

  • Association France Alzheimer (French Alzheimer's Association)

  • Fondation pour la recherche sur le cerveau

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  • You are viewing the most recent version of this article.
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Mitochondrial OPA1 Deficiency Is Associated to Reversible Defects in Spatial Memory Related to Adult Neurogenesis in Mice
Trinovita Andraini, Lionel Moulédous, Petnoi Petsophonsakul, Cédrick Florian, Sébastien Gauzin, Marlène Botella-Daloyau, Macarena Arrázola, Kamela Nikolla, Adam Philip, Alice Leydier, Manon Marque, Laetitia Arnauné-Pelloquin, Pascale Belenguer, Claire Rampon, Marie-Christine Miquel
eNeuro 20 October 2023, 10 (11) ENEURO.0073-23.2023; DOI: 10.1523/ENEURO.0073-23.2023

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Mitochondrial OPA1 Deficiency Is Associated to Reversible Defects in Spatial Memory Related to Adult Neurogenesis in Mice
Trinovita Andraini, Lionel Moulédous, Petnoi Petsophonsakul, Cédrick Florian, Sébastien Gauzin, Marlène Botella-Daloyau, Macarena Arrázola, Kamela Nikolla, Adam Philip, Alice Leydier, Manon Marque, Laetitia Arnauné-Pelloquin, Pascale Belenguer, Claire Rampon, Marie-Christine Miquel
eNeuro 20 October 2023, 10 (11) ENEURO.0073-23.2023; DOI: 10.1523/ENEURO.0073-23.2023
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Keywords

  • adult neurogenesis
  • dominant optic atrophy
  • hippocampus
  • mitochondria
  • pattern separation
  • physical exercise

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