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Research ArticleResearch Article: Negative Results, Disorders of the Nervous System

Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons

A. J. Keefe, D. R. Gabrych, Y. Zhu, D. J. Vocadlo and M. A. Silverman
eNeuro 10 October 2023, 10 (10) ENEURO.0079-23.2023; https://doi.org/10.1523/ENEURO.0079-23.2023
A. J. Keefe
1Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
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D. R. Gabrych
1Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
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Y. Zhu
3Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
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D. J. Vocadlo
2Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
3Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
4Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
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M. A. Silverman
1Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
2Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0079-23.2023
PubMed 
37816595
Published By 
Society for Neuroscience
History 
  • Received February 22, 2023
  • Revision received September 18, 2023
  • Accepted September 20, 2023
  • Published online October 10, 2023.
Copyright & Usage 
Copyright © 2023 Keefe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. A. J. Keefe1,
  2. D. R. Gabrych1,
  3. Y. Zhu3,
  4. D. J. Vocadlo2,3,4 and
  5. M. A. Silverman1,2
  1. 1Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
  2. 2Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
  3. 3Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
  4. 4Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
  1. Correspondence should be addressed to M. A. Silverman at masilver{at}sfu.ca.
View Full Text

Author contributions

  1. Author contributions: M.A.S., A.J.K., Y.Z., and D.J.V. designed research; A.J.K. and Y.Z. performed research; M.A.S., A.J.K., D.R.G., Y.Z., and D.J.V. analyzed data; M.A.S., A.J.K., D.R.G., Y.Z., and D.J.V. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • D.J.V. is supported by the Natural Sciences and Engineering Council of Canada (NSERC) Grant RGPIN-06466. D.J.V. and M.A.S. were supported by the Canadian Glycomics Network (GlycoNet) Grant RG-1. M.A.S. is supported by the NSERC Grant RGPIN-03945.

Funding

  • Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)

    RGPIN-03945; RGPIN-06466
  • UofA | Canadian Glycomics Network (GlycoNet)

    RG-1; RG-1

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AbstractFullPdf
Oct 2023437663205
Nov 20234029186
Dec 20231516548
Total 20234921119339
Jan 20241313554
Feb 20241812731
Mar 202489842
Apr 20242011352
May 2024610439
Jun 20241227355
Jul 2024810643
Aug 2024137827
Sep 2024217546
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Dec 202487422
Total 20241451361455
Jan 202589529
Feb 2025811919
Mar 2025189445
Apr 202579834
May 202598215
Jun 2025610934
Jul 2025712226
Aug 2025712431
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Oct 20251213817
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Dec 20251322
Total 20251101248299
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eneuro: 10 (10)
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October 2023
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Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons
A. J. Keefe, D. R. Gabrych, Y. Zhu, D. J. Vocadlo, M. A. Silverman
eNeuro 10 October 2023, 10 (10) ENEURO.0079-23.2023; DOI: 10.1523/ENEURO.0079-23.2023

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Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons
A. J. Keefe, D. R. Gabrych, Y. Zhu, D. J. Vocadlo, M. A. Silverman
eNeuro 10 October 2023, 10 (10) ENEURO.0079-23.2023; DOI: 10.1523/ENEURO.0079-23.2023
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Keywords

  • axonal transport
  • conduritol B epoxide
  • glucocerebrosidase
  • lysosomes

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