Research ArticleResearch Article: New Research, Disorders of the Nervous System

The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease

Alexa F. Iannitelli, Michael A. Kelberman, Daniel J. Lustberg, Anu Korukonda, Katharine E. McCann, Bernard Mulvey, Arielle Segal, L. Cameron Liles, Steven A. Sloan, Joseph D. Dougherty and David Weinshenker
eNeuro 9 December 2022, 10 (1) ENEURO.0483-22.2022; https://doi.org/10.1523/ENEURO.0483-22.2022

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0483-22.2022
PubMed 
36635251
Published By 
Society for Neuroscience
History 
  • Received November 26, 2022
  • Accepted December 2, 2022
  • Published online December 9, 2022.
Copyright & Usage 
Copyright © 2023 Iannitelli et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Alexa F. Iannitelli1,
  2. Michael A. Kelberman1,
  3. Daniel J. Lustberg1,
  4. Anu Korukonda1,
  5. Katharine E. McCann1,
  6. Bernard Mulvey2,
  7. Arielle Segal1,
  8. L. Cameron Liles1,
  9. Steven A. Sloan1,
  10. Joseph D. Dougherty2,3 and
  11. David Weinshenker1
  1. 1Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322
  2. 2Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110
  3. 3Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110
  1. Correspondence should be addressed to David Weinshenker at dweinsh{at}emory.edu.
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Author contributions

  1. Author contributions: A.F.I., M.A.K., D.J.L., B.M., L.C.L., S.A.S., J.D.D., and D.W. designed research; A.F.I., M.A.K., D.J.L., and A.K. performed research; J.D.D. contributed unpublished reagents/analytic tools; A.F.I., M.A.K., D.J.L., A.K., K.E.M., B.M., A.S., L.C.L., and S.A.S. analyzed data; A.F.I., M.A.K., K.E.M., and D.W. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institutes of Health (NIH) National Institute of Environmental Health Sciences Training Grant ES12870 and the NIH D-SPAN F99/K00 Award from the National Institute of Neurological Disorders and Stroke (NS129168; to A.F.I.) and RF1 Awards from the National Institute on Aging (AG079199 and AG061175; to D.W.). This study was supported in part by the Emory HPLC Bioanalytical Core (EHBC), which is subsidized by the Emory University School of Medicine and is one of the Emory Integrated Core Facilities. Additional support was provided by the Georgia Clinical and Translational Science Alliance of the NIH under Award Number UL1TR002378.

Funding

  • HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)

    ES12870

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    NS129168

  • HHS | NIH | National Institute on Aging (NIA)

    AG079199; AG061175

  • Georgia Clinical and Translational Science Alliance (CTSA)

    UL1TR002378

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Article usage: December 2022 to June 2025

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Total99440901639
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The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease
Alexa F. Iannitelli, Michael A. Kelberman, Daniel J. Lustberg, Anu Korukonda, Katharine E. McCann, Bernard Mulvey, Arielle Segal, L. Cameron Liles, Steven A. Sloan, Joseph D. Dougherty, David Weinshenker
eNeuro 9 December 2022, 10 (1) ENEURO.0483-22.2022; DOI: 10.1523/ENEURO.0483-22.2022
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