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Research ArticleResearch Article: New Research, Cognition and Behavior

Age-Related Changes in Risky Decision Making and Associated Neural Circuitry in a Rat Model

Caitlin A. Orsini, Wonn S. Pyon, Richard J. Dragone, Mojdeh Faraji, Alexa-Rae Wheeler, Marjory Pompilus, Marcelo Febo, Jennifer L. Bizon and Barry Setlow
eNeuro 3 January 2023, 10 (1) ENEURO.0385-22.2022; https://doi.org/10.1523/ENEURO.0385-22.2022
Caitlin A. Orsini
1Department of Psychiatry, University of Florida, Gainesville, Florida 32610
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  • ORCID record for Caitlin A. Orsini
Wonn S. Pyon
2Department of Neuroscience, University of Florida, Gainesville, Florida 32610
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Richard J. Dragone
1Department of Psychiatry, University of Florida, Gainesville, Florida 32610
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Mojdeh Faraji
1Department of Psychiatry, University of Florida, Gainesville, Florida 32610
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Alexa-Rae Wheeler
2Department of Neuroscience, University of Florida, Gainesville, Florida 32610
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Marjory Pompilus
1Department of Psychiatry, University of Florida, Gainesville, Florida 32610
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Marcelo Febo
1Department of Psychiatry, University of Florida, Gainesville, Florida 32610
3McKnight Brain Institute, University of Florida, Gainesville, Florida 32610
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Jennifer L. Bizon
2Department of Neuroscience, University of Florida, Gainesville, Florida 32610
3McKnight Brain Institute, University of Florida, Gainesville, Florida 32610
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Barry Setlow
1Department of Psychiatry, University of Florida, Gainesville, Florida 32610
3McKnight Brain Institute, University of Florida, Gainesville, Florida 32610
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0385-22.2022
PubMed 
36596593
Published By 
Society for Neuroscience
History 
  • Received September 8, 2022
  • Revision received December 7, 2022
  • Accepted December 13, 2022
  • Published online January 3, 2023.
Copyright & Usage 
Copyright © 2023 Orsini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Caitlin A. Orsini1,*,
  2. Wonn S. Pyon2,*,
  3. Richard J. Dragone1,
  4. Mojdeh Faraji1,
  5. Alexa-Rae Wheeler2,
  6. Marjory Pompilus1,
  7. Marcelo Febo1,3,
  8. Jennifer L. Bizon2,3 and
  9. Barry Setlow1,3
  1. 1Department of Psychiatry, University of Florida, Gainesville, Florida 32610
  2. 2Department of Neuroscience, University of Florida, Gainesville, Florida 32610
  3. 3McKnight Brain Institute, University of Florida, Gainesville, Florida 32610
  1. Correspondence should be addressed to Barry Setlow at setlow{at}ufl.edu.
  • C.A. Orsini’s present address: Department of Psychology, Waggoner Center for Alcohol & Addiction Research, The University of Texas at Austin, Austin, TX 78712.

  • A.-R. Wheeler’s present address: Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712.

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Author contributions

  1. Author contributions: C.A.O., M. Faraji, M. Febo, J.L.B., and B.S. designed research; C.A.O., W.S.P., R.J.D., A.-R.W., and M.P. performed research; C.A.O., W.S.P., R.J.D., and M. Faraji analyzed data; C.A.O., W.S.P., M. Faraji, M. Febo, J.L.B., and B.S. wrote the paper.

  • C.A. Orsini’s present address: Department of Psychology, Waggoner Center for Alcohol & Addiction Research, The University of Texas at Austin, Austin, TX 78712.

  • A.-R. Wheeler’s present address: Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Department of Health and Human Services (HHS) | National Institutes of Health (NIH) | National Institute on Aging (NIA) Grant RF1-AG-060778 (J.L.B., B.S.), a McKnight Brain Institute Fellowship, a Thomas H. Maren Fellowship, HHS | NIH | National Institute on Drug Abuse Grant K99-DA-041493 (C.A.O.), HHS | NIH | NIA T32-AG-061892 (W.S.P., R.J.D.), and the McKnight Brain Research Foundation (J.L.B.).

  • ↵* C.A.O. and W.S.P. are co-first authors.

Funding

  • HHS | NIH | National Institute on Aging (NIA)

    RF1AG060778; T32AG061892
  • McKnight Brain Institute

  • Thomas H Maren

  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    K99DA041493
  • Evelyn F. McKnight Brain Research Foundation (MBRF)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (January 03, 2023).

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Article usage: January 2023 to January 2026

AbstractFullPdf
Jan 2023259320145
Feb 20233515642
Mar 20234113045
Apr 20232314240
May 2023199425
Jun 20232011828
Jul 20231311415
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Total 20234801636451
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Total 20241231812253
Jan 2025610521
Feb 2025712816
Mar 2025714227
Apr 20251512615
May 2025611022
Jun 2025189824
Jul 20252613523
Aug 20251513247
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Oct 20251713447
Nov 20252114632
Dec 20252217241
Total 20251801692347
Jan 202685010
Total 202685010
Total79151901061
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Age-Related Changes in Risky Decision Making and Associated Neural Circuitry in a Rat Model
Caitlin A. Orsini, Wonn S. Pyon, Richard J. Dragone, Mojdeh Faraji, Alexa-Rae Wheeler, Marjory Pompilus, Marcelo Febo, Jennifer L. Bizon, Barry Setlow
eNeuro 3 January 2023, 10 (1) ENEURO.0385-22.2022; DOI: 10.1523/ENEURO.0385-22.2022

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Age-Related Changes in Risky Decision Making and Associated Neural Circuitry in a Rat Model
Caitlin A. Orsini, Wonn S. Pyon, Richard J. Dragone, Mojdeh Faraji, Alexa-Rae Wheeler, Marjory Pompilus, Marcelo Febo, Jennifer L. Bizon, Barry Setlow
eNeuro 3 January 2023, 10 (1) ENEURO.0385-22.2022; DOI: 10.1523/ENEURO.0385-22.2022
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Keywords

  • aging
  • decision making
  • neuroimaging
  • punishment
  • rat
  • risk taking

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