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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer’s Disease Brains and Mouse Neurodegeneration Models

Nozie D. Aghaizu, Sarah Jolly, Satinder K. Samra, Bernadett Kalmar, Katleen Craessaerts, Linda Greensmith, Patricia C. Salinas, Bart De Strooper and Paul J. Whiting
eNeuro 4 January 2023, 10 (1) ENEURO.0306-22.2022; https://doi.org/10.1523/ENEURO.0306-22.2022
Nozie D. Aghaizu
1United Kingdom Dementia Research Institute at University College London, London WC1E 6BT, United Kingdom
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  • ORCID record for Nozie D. Aghaizu
Sarah Jolly
2Alzheimer's Research UK Drug Discovery Institute (DDI), University College London, London WC1E 6BT, United Kingdom
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Satinder K. Samra
1United Kingdom Dementia Research Institute at University College London, London WC1E 6BT, United Kingdom
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Bernadett Kalmar
3Department of Neuromuscular Diseases, University College London Queen Square Motor Neuron Disease Centre, Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
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Katleen Craessaerts
5Vlaams Instituut voor Biotechnologie Centre for Brain Disease Research, Leuven 3000, Belgium
6Department of Neurosciences and Leuven Brain Institute, Katholieke Universiteit Leuven, Leuven 3000, Belgium
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Linda Greensmith
3Department of Neuromuscular Diseases, University College London Queen Square Motor Neuron Disease Centre, Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
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Patricia C. Salinas
4Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
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Bart De Strooper
1United Kingdom Dementia Research Institute at University College London, London WC1E 6BT, United Kingdom
5Vlaams Instituut voor Biotechnologie Centre for Brain Disease Research, Leuven 3000, Belgium
6Department of Neurosciences and Leuven Brain Institute, Katholieke Universiteit Leuven, Leuven 3000, Belgium
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Paul J. Whiting
1United Kingdom Dementia Research Institute at University College London, London WC1E 6BT, United Kingdom
2Alzheimer's Research UK Drug Discovery Institute (DDI), University College London, London WC1E 6BT, United Kingdom
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0306-22.2022
PubMed 
36599670
Published By 
Society for Neuroscience
History 
  • Received July 25, 2022
  • Revision received December 12, 2022
  • Accepted December 13, 2022
  • Published online January 4, 2023.
Copyright & Usage 
Copyright © 2023 Aghaizu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Nozie D. Aghaizu1,
  2. Sarah Jolly2,
  3. Satinder K. Samra1,
  4. Bernadett Kalmar3,
  5. Katleen Craessaerts5,6,
  6. Linda Greensmith3,
  7. Patricia C. Salinas4,
  8. Bart De Strooper1,5,6 and
  9. Paul J. Whiting1,2
  1. 1United Kingdom Dementia Research Institute at University College London, London WC1E 6BT, United Kingdom
  2. 2Alzheimer's Research UK Drug Discovery Institute (DDI), University College London, London WC1E 6BT, United Kingdom
  3. 3Department of Neuromuscular Diseases, University College London Queen Square Motor Neuron Disease Centre, Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
  4. 4Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
  5. 5Vlaams Instituut voor Biotechnologie Centre for Brain Disease Research, Leuven 3000, Belgium
  6. 6Department of Neurosciences and Leuven Brain Institute, Katholieke Universiteit Leuven, Leuven 3000, Belgium
  1. Correspondence should be addressed to Nozie D. Aghaizu at nozie.aghaizu{at}ucl.ac.uk or Sarah Jolly at sarah.jolly{at}ucl.ac.uk.
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Author contributions

  1. Author contributions: N.D.A., S.J., and P.J.W. designed research; N.D.A., S.K.S., B.K., K.C., L.G., P.C.S., B.D.S., and P.J.W. performed research; N.D.A. and S.J. contributed unpublished reagents/analytic tools; N.D.A. analyzed data; N.D.A., S.J., L.G., P.C.S., B.D.S., and P.J.W. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the United Kingdom Dementia Research Institute, which receives its funding from DRI Ltd, funded by the United Kingdom Medical Research Council, Alzheimer’s Society, and Alzheimer’s Research United Kingdom. L.G. and B.K. are supported by Brain Research United Kingdom and the Rosetrees Trust.

Funding

  • DRI Ltd.

  • Brain Research UK (BRUK)

  • Rosetrees Trust (Rosetrees)

Other Version

  • You are viewing the most recent version of this article.
  • previous version (January 04, 2023).

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Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer’s Disease Brains and Mouse Neurodegeneration Models
Nozie D. Aghaizu, Sarah Jolly, Satinder K. Samra, Bernadett Kalmar, Katleen Craessaerts, Linda Greensmith, Patricia C. Salinas, Bart De Strooper, Paul J. Whiting
eNeuro 4 January 2023, 10 (1) ENEURO.0306-22.2022; DOI: 10.1523/ENEURO.0306-22.2022

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Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer’s Disease Brains and Mouse Neurodegeneration Models
Nozie D. Aghaizu, Sarah Jolly, Satinder K. Samra, Bernadett Kalmar, Katleen Craessaerts, Linda Greensmith, Patricia C. Salinas, Bart De Strooper, Paul J. Whiting
eNeuro 4 January 2023, 10 (1) ENEURO.0306-22.2022; DOI: 10.1523/ENEURO.0306-22.2022
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Keywords

  • Alzheimer’s disease
  • microglia
  • neurodegeneration
  • neuroinflammation
  • Wnt signaling

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