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Research ArticleResearch Article: Methods/New Tools, Novel Tools and Methods

Home-Enclosure-Based Behavioral and Wireless Neural Recording Setup for Unrestrained Rhesus Macaques

Laura Hansmeyer, Pinar Yurt, Naubahar Agha, Attila Trunk, Michael Berger, Antonino Calapai, Stefan Treue and Alexander Gail
eNeuro 23 December 2022, 10 (1) ENEURO.0285-22.2022; https://doi.org/10.1523/ENEURO.0285-22.2022
Laura Hansmeyer
1Cognitive Neuroscience Laboratory, German Primate Center, 37077 Göttingen, Germany
5Göttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences, University of Göttingen, 37073 Göttingen, Germany
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Pinar Yurt
1Cognitive Neuroscience Laboratory, German Primate Center, 37077 Göttingen, Germany
4Georg-August University School of Science, 37073 Göttingen, Germany
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Naubahar Agha
1Cognitive Neuroscience Laboratory, German Primate Center, 37077 Göttingen, Germany
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Attila Trunk
1Cognitive Neuroscience Laboratory, German Primate Center, 37077 Göttingen, Germany
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Michael Berger
1Cognitive Neuroscience Laboratory, German Primate Center, 37077 Göttingen, Germany
7Laboratory of Neural Systems, The Rockefeller University, New York, NY 10065
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Antonino Calapai
1Cognitive Neuroscience Laboratory, German Primate Center, 37077 Göttingen, Germany
3Leibniz ScienceCampus Primate Cognition, 37077 Göttingen, Germany
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Stefan Treue
1Cognitive Neuroscience Laboratory, German Primate Center, 37077 Göttingen, Germany
2Bernstein Center for Computational Neuroscience, University of Göttingen, 37073 Göttingen, Germany
3Leibniz ScienceCampus Primate Cognition, 37077 Göttingen, Germany
6Faculty for Biology and Psychology, University of Göttingen, 37073 Göttingen, Germany
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Alexander Gail
1Cognitive Neuroscience Laboratory, German Primate Center, 37077 Göttingen, Germany
2Bernstein Center for Computational Neuroscience, University of Göttingen, 37073 Göttingen, Germany
3Leibniz ScienceCampus Primate Cognition, 37077 Göttingen, Germany
6Faculty for Biology and Psychology, University of Göttingen, 37073 Göttingen, Germany
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    Figure 1.

    Experimental setup and task design. A, Schematic of the experimental setting. The recording sessions take place inside the testing area (shown in yellow) next to the group housing. Four antennas (shown in green) are installed at the ceiling of the testing area. The experimenter has access to the XBI (shown in orange) from the back. The data acquisition system is shown in blue. B, Animal K working on the XBI inside the testing area. The wireless head stages are protected with a cap (shown in purple). C, Data flow during recordings. Neural signals are collected, digitized, and sent wirelessly to the receiving antennas. At the same time the animal interacts through a touch screen with the XBI. Neural signals are sent to the acquisition system together with time stamps for trial starts for offline synchronization with behavioral data. D, Behavioral task design. The animals are required to perform two consecutive reaches to a first target in the lower row and a second target in the upper row. Upon touching the starting position, two possible targets appear in both rows together with two color cues next to the starting position, indicating the correct target in each row. Circles with white dashed lines show additional possible reach target (not visible to the animal). Reach target and colors are randomized trial-wise. The second reach is greyed out as analysis in this study only includes times until touching the first target.

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    Figure 2.

    Wireless recording in home enclosure. Each row represents the neural signal from an example electrode. One electrode per recorded area is shown. Red traces show the raw data trace from one example trial. The second column shows the extracted average wave forms after preprocessing and spike sorting, based on a principal component (PC) analysis. Corresponding clusters in first two PCs are shown on the right. For visualization purposes we only show the first two PCs. For spike sorting we used additional features including third PC, nonlinear energy, and interspike interval. Colored traces below raw data represent spike trains for each sorted unit in the example trial. Shaded areas for wave forms indicate standard deviation.

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    Figure 3.

    Neural selectivity for spatial task parameters. Each subfigure shows the target position dependent tuning for one example unit from each recorded area. For each unit, a raster plot and averaged spike densities are shown aligned to three different task events (instruction of reach target, go cue, movement onset). Colors correspond to four different horizontally aligned target positions (shown at the top). Shaded areas show standard error of the mean. The panel on the right shows the mean firing rate of the unit from the highlighted alignment for the four-target positions. Error bars correspond to 95% CI.

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January 2023
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Home-Enclosure-Based Behavioral and Wireless Neural Recording Setup for Unrestrained Rhesus Macaques
Laura Hansmeyer, Pinar Yurt, Naubahar Agha, Attila Trunk, Michael Berger, Antonino Calapai, Stefan Treue, Alexander Gail
eNeuro 23 December 2022, 10 (1) ENEURO.0285-22.2022; DOI: 10.1523/ENEURO.0285-22.2022

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Home-Enclosure-Based Behavioral and Wireless Neural Recording Setup for Unrestrained Rhesus Macaques
Laura Hansmeyer, Pinar Yurt, Naubahar Agha, Attila Trunk, Michael Berger, Antonino Calapai, Stefan Treue, Alexander Gail
eNeuro 23 December 2022, 10 (1) ENEURO.0285-22.2022; DOI: 10.1523/ENEURO.0285-22.2022
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  • Cage-based testing
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