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Research ArticleResearch Article: New Research, Disorders of the Nervous System

Spinal Cord Injury AIS Predictions Using Machine Learning

Dhruv Kapoor and Clark Xu
eNeuro 21 December 2022, 10 (1) ENEURO.0149-22.2022; https://doi.org/10.1523/ENEURO.0149-22.2022
Dhruv Kapoor
1College of Computing, Georgia Institute of Technology, Atlanta, Georgia 30332
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Clark Xu
1College of Computing, Georgia Institute of Technology, Atlanta, Georgia 30332
2Department of Medicine, School of Medicine and Public Health, University of Wisconsin–Madison, Madison, Wisconsin 53705
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  • Figure 1.
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    Figure 1.

    Data preparation flowchart through to model selection (full image is available at: https://github.com/kapoor1992/spinal_cord_injury_recovery/blob/release/submission/src/ml/modelling/plots/flowchart.png).

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    Figure 2.

    Top 20 most important features (full image is available at: https://github.com/kapoor1992/spinal_cord_injury_recovery/blob/release/submission/src/ml/modelling/plots/importance.png).

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    Table 1

    Feature mappings from those in the original dataset to transformed versions used at model training time, along with the imputation techniques used

    Original featureMachine learning featuresMissing value imputation technique
    Occupation status—injuryHomemaker, in training, in workshop, other, retired, student or infant,
    unemployed, unknown, working
    Mapped to unknown
    Diabetes—historySame as original featureMode (no history)
    VeteranSame as original featureMode (not a veteran)
    RaceAsian, black, multiracial, Native American, unknown, whiteMapped to unknown
    AIS—admissionA, B, C, DNone; rows dropped
    SexSame as original featureNone; all values were populated
    Education—injurySame as original featureMode (high school)
    Depression—historySame as original featureMode (no history)
    TBI likelihood—injurySame as original featureMode (improbable)
    Level of injury—admissionSame as original featureNone; rows dropped
    Daily alcohol—historySame as original featureMode (zero)
    Anxiety—historyFalse, general anxiety, multiple, PTSD, panic disorder, unknownMapped to unknown
    Primary insuranceTrue, false, unknownMapped to unknown
    Age—injurySame as original featureNone; all values were populated
    Loss of memory—injurySame as original featureMode (no loss of memory)
    Marital status—injuryDivorced, living unmarried with partner, married, never married,
    other, separated, unknown, widowed
    Mapped to unknown
    Neurologic category—
    admission
    Complete paraplegic, complete tetraplegic, incomplete paraplegic,
    incomplete tetraplegic, minimal deficit paraplegic, minimal deficit
    tetraplegic, unknown
    Mapped to unknown
    Loss of consciousness—
    injury
    Same as original featureMode (no loss of consciousness)
    • TBI, Traumatic brain injury.

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    Table 2

    Final dataset at a glance that was used for machine learning

    DescriptionValue
    Total samples20,790
    Training samples18,737
    Training injury dates1972–2005
    Testing samples2053
    Testing injury dates2006–2016
    Original features18
    Machine learning features53
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    Table 3

    Accuracy results from machine learning model runs, ordered in descending order by test accuracy

    ModelTrain accuracyTest accuracy
    Ridge Classifier0.8240.736
    SVM0.8250.735
    Elastic Net0.8230.732
    Logistic regression0.8240.732
    Ensemble (Elastic Net, KNN,
    Random Forest)
    0.8600.717
    CNN0.8400.711
    Random Forest0.9270.693
    Naive Bayes0.5910.429
    • View popup
    Table 4

    Top 20 most important features for Ridge Classifier

    RankMachine learning feature
    1AIS—admission_A
    2AIS—admission_D
    3AIS—admission_B
    4Neurologic category—admission_complete paraplegic
    5Neurologic category—admission_incomplete tetraplegic
    6AIS—admission_C
    7Neurologic category—admission_complete tetraplegic
    8Neurologic category—admission_incomplete paraplegic
    9Level of Injury—admission
    10Marital status—injury_never married
    11Marital status—injury_married
    12Occupation status—injury_working
    13Primary insurance_unknown
    14Occupation status—injury_student or infant
    15Age—injury
    16Marital status—injury_divorced
    17Race_white
    18Sex
    19Occupation status—injury_retired
    20Education—injury

Extended Data

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    Spinal cord injury recovery-release-submission. Download Extended Data 1, ZIP file

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Spinal Cord Injury AIS Predictions Using Machine Learning
Dhruv Kapoor, Clark Xu
eNeuro 21 December 2022, 10 (1) ENEURO.0149-22.2022; DOI: 10.1523/ENEURO.0149-22.2022

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Spinal Cord Injury AIS Predictions Using Machine Learning
Dhruv Kapoor, Clark Xu
eNeuro 21 December 2022, 10 (1) ENEURO.0149-22.2022; DOI: 10.1523/ENEURO.0149-22.2022
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Keywords

  • machine learning
  • NSCISC
  • prediction
  • recovery
  • spinal cord injury

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