Figure 4. Group differences in RS-FC for the aINS and aMCC seeds (SN) and PCC seed (DMN) overlaid onto the average ch2bet brain template in MRIcron. A, Patients showed significant enhancement in aINS and aMCC connectivity with the L cuneus and R lingual gyrus, respectively, and B, reduced connectivity between the PCC seed and bilateral DLPFC, S1, R PPC, R IFG, R ITG, and R mPFC. C, D, RS-FC group differences associated with pain catastrophizing for the aINS and PCC seeds. C, Patients high in catastrophizing showed enhanced RS-FC between the aINS and the L hippocampus, L SMA, and bilateral thalami. D, Significant increases in RS-FC were also identified between the PCC and the bilateral DLPFC in patients with greater pain catastrophizing scores. PAT, Patients; CTL, controls.