Role of centrifugal projections to the olfactory bulb in olfactory processing

  1. Carly L. Kiselycznyk1,
  2. Steven Zhang1, and
  3. Christiane Linster2
  1. Department of Neurobiology and Behavior, Cornell University, Ithaca, New York, USA
  1. 1 These two authors contributed equally to this work.

Abstract

While there is evidence that feedback projections from cortical and neuromodulatory structures to the olfactory bulb are crucial for maintaining the oscillatory dynamics of olfactory bulb processing, it is not clear how changes in dynamics are related to odor perception. Using electrical lesions of the olfactory peduncle, sparing output from the olfactory bulb while decreasing feedback inputs to the olfactory bulb, we demonstrate here a role for feedback inputs to the olfactory bulb in the formation of odor–reward associations, but not for maintaining primary bulbar odor representations, as reflected by spontaneous odor discrimination.

Footnotes

  • 2 Corresponding author.

    2 E-mail cl243{at}cornell.edu; fax (607) 254-4331.

  • Article published online before print. Article and publication date are at http://www.learnmem.org/cgi/doi/10.1101/lm.285706

    • Received April 18, 2006.
    • Accepted June 20, 2006.
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