Behavioral interference and C/EBPβ expression in the insular-cortex reveal a prolonged time period for taste memory consolidation
- Maayan Merhav1,
- Shelly Kuulmann-Vander1,
- Alina Elkobi,
- Shlomit Jacobson-Pick,
- Avi Karni, and
- Kobi Rosenblum2
- Department for Neurobiology and Ethology, Center for Brain and Behavior, University of Haifa, Haifa 31905, Israel
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↵1 These authors contributed equally to this work.
Abstract
Memory consolidation is defined as the time window during which the memory trace is susceptible to behavioral, electrical, or pharmacological interventions. Here, we presented rats with two novel tastes at consecutive time intervals. Clear interference was evident when a novel taste formed the second taste input whereby, surprisingly, the time window for interference was found to last more than 10 h. In addition, we detected an increase of C/EBPβ protein expression in the gustatory cortex 18 h after novel taste learning. This modulation was attenuated by a subsequent novel taste. Our findings reveal temporal constraints and a lingering nature of taste memory consolidation.
Footnotes
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↵2 Corresponding author.
↵2 E-mail kobir{at}psy.haifa.ac.il; fax 972-4-8249654.
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Article published online before print. Article and publication date are at http://www.learnmem.org/cgi/doi/10.1101/lm.282406
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- Received February 20, 2006.
- Accepted June 13, 2006.
- Copyright © 2006, Cold Spring Harbor Laboratory Press
