User profiles for T. D. Yelhekar

Tushar Yelhekar

Massachusetts Institute of Technology (MIT)
Verified email at mit.edu
Cited by 149

[PDF][PDF] Npas4 is a critical regulator of learning-induced plasticity at mossy fiber-CA3 synapses during contextual memory formation

…, D Rich, D Garcia-Dominguez, M Hung, TD Yelhekar… - Neuron, 2018 - cell.com
Synaptic connections between hippocampal mossy fibers (MFs) and CA3 pyramidal neurons
are essential for contextual memory encoding, but the molecular mechanisms regulating …

[HTML][HTML] Development and validation of an in vitro model system to study peripheral sensory neuron development and injury

I Jones, TD Yelhekar, R Wiberg, PJ Kingham… - Scientific reports, 2018 - nature.com
The ability to discriminate between diverse types of sensation is mediated by heterogeneous
populations of peripheral sensory neurons. Human peripheral sensory neurons are …

Contribution of resting conductance, GABAA-receptor mediated miniature synaptic currents and neurosteroid to chloride homeostasis in central neurons

TD Yelhekar, M Druzin, S Johansson - Eneuro, 2017 - eneuro.org
Maintenance of a low intraneuronal Cl – concentration, [Cl – ] i , is critical for inhibition in the
CNS. Here, the contribution of passive, conductive Cl – flux to recovery of [Cl – ] i after a …

[HTML][HTML] How to Properly Measure a Current-Voltage Relation?—Interpolation vs. Ramp Methods Applied to Studies of GABAA Receptors

TD Yelhekar, M Druzin, U Karlsson… - Frontiers in cellular …, 2016 - frontiersin.org
The relation between current and voltage, IV relation, is central to functional analysis of
membrane ion channels. A commonly used method, since the introduction of the voltage-clamp …

A multiple Arc (mArc) tagging system to uncover the organizational principles of multiple memories

M Stackmann, TD Yelhekar, M Meng, X Sun… - bioRxiv, 2024 - biorxiv.org
Engrams or memory traces are the neuronal ensembles that collectively store individual
experiences. Genetic strategies based on immediate early genes (IEGs), such as Arc/Arg3.1, …

Spatiotemporal Mapping and Molecular Basis of Whole-brain Circuit Maturation

J Xue, AT Brawner, JR Thompson, TD Yelhekar… - bioRxiv, 2024 - biorxiv.org
Brain development is highly dynamic and asynchronous, and involves the sequential maturation
of functional circuits across the brain. Due to the inability to identify and map maturing …

[HTML][HTML] Commentary: chloride regulation: a dynamic equilibrium crucial for synaptic inhibition

S Johansson, TD Yelhekar, M Druzin - Frontiers in Cellular …, 2016 - frontiersin.org
The recent review by Doyon et al.(2016) is for the main part an excellent description of many
important aspects of neuronal chloride regulation and will be of good use to many scientists …

Extracellular Matrix Regulates Neuronal Chloride Concentration via K+-Cl-Cotransporter 2

TD Yelhekar, T Kuznetsova, E Malinina, E Ponimaskin… - bioRxiv, 2023 - biorxiv.org
The neuronal intracellular chloride concentration [Cl − ] i is critical for γ‐aminobutyric acid
type A (GABA A ) receptor‐mediated transmission. Degradation of the extracellular matrix (…

Chloride Homeostasis in Central Neurons

T Yelhekar - 2016 - diva-portal.org
The overall aim of the present thesis is to clarify the control of intracellular chloride homeostasis
in central neurons, because of the critical role of chloride ions (Cl–) for neuronal function…

[PDF][PDF] Functionally distinct neuronal ensembles within the memory engram

X Sun, MJ Bernstein, M Meng, S Rao, AT Sørensen… - Cell, 2020 - cell.com
Memories are believed to be encoded by sparse ensembles of neurons in the brain. However,
it remains unclear whether there is functional heterogeneity within individual memory …