Neurologic conditions including stroke, Alzheimer disease, Parkinson disease, and Huntington
disease are leading causes of death and long-term disability in the United States, and …

… At the outset of our studies in 1993, our goal was to identify the target(s) for iron chelators
for two reasons: (1) To identify a way to manipulate the target(s) independent of iron chelation …

Analysis of human pathology led Braak to postulate that α-synuclein (α-syn) pathology could
spread from the gut to brain via the vagus nerve. Here, we test this postulate by assessing α-…

… such as Alzheimer’s disease and Parkinson’s disease 3 , 4 , … mouse model of sporadic
Parkinson’s disease 14 , 15 . NLY01 … the treatment of Parkinson’s disease and related neurologic …

… ’s disease in the United States, affecting 30–50% of individuals aged 85 and older [37]. The
specific cause of Alzheimer’s … a prominent feature in Alzheimer’s pathology [75]. Therapeutic …

INTRODUCTION Parkinson’s disease (PD) is the second most common neurodegenerative
disorder and leads to slowness of movement, tremor, rigidity, and, in the later stages of PD, …

10.7554/eLife.15092.001 Exercise induces beneficial responses in the brain, which is
accompanied by an increase in BDNF, a trophic factor associated with cognitive improvement and …

Ferroptosis, a non-apoptotic form of programmed cell death, is triggered by oxidative stress
in cancer, heat stress in plants, and hemorrhagic stroke. A homeostatic transcriptional …

… S staining was used. Briefly, sections were washed with distilled water for 5 min and stained
in freshly prepared and filtered aqueous 0.5% thioflavine S … by the thioflavine S positive …

INTRODUCTION Parkinson’s disease (PD) is the second most common neurodegenerative
disorder. Intracellular protein aggregates composed primarily of α-synuclein lead to …