User profiles for R. W. Gereau

Robert Gereau

Washington University School of Medicine
Verified email at wustl.edu
Cited by 19006

MAP kinase and pain

RR Ji, RW Gereau IV, M Malcangio, GR Strichartz - Brain research reviews, 2009 - Elsevier
Mitogen-activated protein kinases (MAPKs) are important for intracellular signal transduction
and play critical roles in regulating neural plasticity and inflammatory responses. The MAPK …

[PDF][PDF] Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch

…, A Schaffer, F Brombacher, CS Hsieh, RW Gereau… - Cell, 2017 - cell.com
Mammals have evolved neurophysiologic reflexes, such as coughing and scratching, to
expel invading pathogens and noxious environmental stimuli. It is well established that these …

Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics

…, JP Golden, MR Bruchas, RW Gereau IV… - Nature …, 2015 - nature.com
Optogenetics allows rapid, temporally specific control of neuronal activity by targeted expression
and activation of light-sensitive proteins. Implementation typically requires remote light …

[PDF][PDF] cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation

…, W Zhu, H Wang, DJ Brasier, GS Oxford, RW Gereau - Neuron, 2002 - cell.com
The capsaicin receptor, VR1 (also known as TRPV1), is a ligand-gated ion channel expressed
on nociceptive sensory neurons that responds to noxious thermal and chemical stimuli. …

Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors

…, BA Copits, PM Dougherty, RW Gereau IV… - Science translational …, 2022 - science.org
Nociceptors are specialized sensory neurons that detect damaging or potentially damaging
stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These …

Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-α

X Jin, RW Gereau - Journal of Neuroscience, 2006 - Soc Neuroscience
… excitability and action potential propagation (Bhave and Gereau, 2004). For example, the …
We thank the members of the Gereau laboratory for critical comments on this manuscript …

Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)

…, GS Oxford, RW Gereau IV - Proceedings of the …, 2003 - National Acad Sciences
Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor
potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the …

Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice

F Karim, CC Wang, RW Gereau - Journal of Neuroscience, 2001 - Soc Neuroscience
Metabotropic glutamate receptors are expressed abundantly in the spinal cord and have been
shown to play important roles in the modulation of nociceptive transmission and plasticity. …

A wireless closed-loop system for optogenetic peripheral neuromodulation

…, H Jang, Y Li, HH Lai, Y Huang, SI Park, RW Gereau IV… - Nature, 2019 - nature.com
The fast-growing field of bioelectronic medicine aims to develop engineered systems that
can relieve clinical conditions by stimulating the peripheral nervous system 1 , 2 , 3 , 4 – 5 . …

[PDF][PDF] Flexible near-field wireless optoelectronics as subdermal implants for broad applications in optogenetics

…, X Feng, T Kim, JK Kim, Y Li, Y Huang, RW Gereau… - Neuron, 2017 - cell.com
In vivo optogenetics provides unique, powerful capabilities in the dissection of neural circuits
implicated in neuropsychiatric disorders. Conventional hardware for such studies, however, …