User profiles for R. W. Gereau
Robert GereauWashington University School of Medicine Verified email at wustl.edu Cited by 19006 |
MAP kinase and pain
Mitogen-activated protein kinases (MAPKs) are important for intracellular signal transduction
and play critical roles in regulating neural plasticity and inflammatory responses. The MAPK …
and play critical roles in regulating neural plasticity and inflammatory responses. The MAPK …
[PDF][PDF] Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch
…, A Schaffer, F Brombacher, CS Hsieh, RW Gereau… - Cell, 2017 - cell.com
Mammals have evolved neurophysiologic reflexes, such as coughing and scratching, to
expel invading pathogens and noxious environmental stimuli. It is well established that these …
expel invading pathogens and noxious environmental stimuli. It is well established that these …
Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics
…, JP Golden, MR Bruchas, RW Gereau IV… - Nature …, 2015 - nature.com
Optogenetics allows rapid, temporally specific control of neuronal activity by targeted expression
and activation of light-sensitive proteins. Implementation typically requires remote light …
and activation of light-sensitive proteins. Implementation typically requires remote light …
[PDF][PDF] cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation
…, W Zhu, H Wang, DJ Brasier, GS Oxford, RW Gereau - Neuron, 2002 - cell.com
The capsaicin receptor, VR1 (also known as TRPV1), is a ligand-gated ion channel expressed
on nociceptive sensory neurons that responds to noxious thermal and chemical stimuli. …
on nociceptive sensory neurons that responds to noxious thermal and chemical stimuli. …
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors
…, BA Copits, PM Dougherty, RW Gereau IV… - Science translational …, 2022 - science.org
Nociceptors are specialized sensory neurons that detect damaging or potentially damaging
stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These …
stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These …
Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-α
X Jin, RW Gereau - Journal of Neuroscience, 2006 - Soc Neuroscience
… excitability and action potential propagation (Bhave and Gereau, 2004). For example, the …
We thank the members of the Gereau laboratory for critical comments on this manuscript …
We thank the members of the Gereau laboratory for critical comments on this manuscript …
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
…, GS Oxford, RW Gereau IV - Proceedings of the …, 2003 - National Acad Sciences
Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor
potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the …
potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the …
Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice
Metabotropic glutamate receptors are expressed abundantly in the spinal cord and have been
shown to play important roles in the modulation of nociceptive transmission and plasticity. …
shown to play important roles in the modulation of nociceptive transmission and plasticity. …
A wireless closed-loop system for optogenetic peripheral neuromodulation
…, H Jang, Y Li, HH Lai, Y Huang, SI Park, RW Gereau IV… - Nature, 2019 - nature.com
The fast-growing field of bioelectronic medicine aims to develop engineered systems that
can relieve clinical conditions by stimulating the peripheral nervous system 1 , 2 , 3 , 4 – 5 . …
can relieve clinical conditions by stimulating the peripheral nervous system 1 , 2 , 3 , 4 – 5 . …
[PDF][PDF] Flexible near-field wireless optoelectronics as subdermal implants for broad applications in optogenetics
In vivo optogenetics provides unique, powerful capabilities in the dissection of neural circuits
implicated in neuropsychiatric disorders. Conventional hardware for such studies, however, …
implicated in neuropsychiatric disorders. Conventional hardware for such studies, however, …