User profiles for R. A. Espaņa
 | Rodrigo A. EspaņaDrexel University Verified email at DrexelMed.edu Cited by 6487 |
Noradrenergic modulation of wakefulness/arousal
The locus coeruleus-noradrenergic system supplies norepinephrine throughout the central
nervous system. State-dependent neuronal discharge activity of locus coeruleus …
nervous system. State-dependent neuronal discharge activity of locus coeruleus …
Sleep neurobiology from a clinical perspective
RA Espaņa, TE Scammell - Sleep, 2011 - academic.oup.com
Many neurochemical systems interact to generate wakefulness and sleep. Wakefulness is
promoted by neurons in the pons, midbrain, and posterior hypothalamus that produce …
promoted by neurons in the pons, midbrain, and posterior hypothalamus that produce …
Hypocretin/orexin in arousal and stress
… (alpha-helical CRF 12-41 ; Espaņa and Berridge, unpublished observations). This effect of
… < 0.01 significantly different from V + 0.7 (Espaņa and Berridge, unpublished observations). …
… < 0.01 significantly different from V + 0.7 (Espaņa and Berridge, unpublished observations). …
Afferents to the orexin neurons of the rat brain
Emotions, stress, hunger, and circadian rhythms all promote wakefulness and behavioral
arousal. Little is known about the pathways mediating these influences, but the orexin-…
arousal. Little is known about the pathways mediating these influences, but the orexin-…
Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action
RA Espana, BA Baldo, AE Kelley, CW Berridge - Neuroscience, 2001 - Elsevier
The hypocretins (orexins) are a newly identified peptide family comprised of two peptides,
hypocretin-1 and hypocretin-2. Recent observations suggest an involvement of these peptides …
hypocretin-1 and hypocretin-2. Recent observations suggest an involvement of these peptides …
Concomitant loss of dynorphin, NARP, and orexin in narcolepsy
Background: Narcolepsy with cataplexy is associated with a loss of orexin/hypocretin. It is
speculated that an autoimmune process kills the orexin-producing neurons, but these cells …
speculated that an autoimmune process kills the orexin-producing neurons, but these cells …
Clozapine N-oxide administration produces behavioral effects in Long–Evans rats: implications for designing DREADD experiments
Clozapine N-oxide (CNO) is a ligand for a powerful chemogenetic system that can selectively
inhibit or activate neurons; the so-called Designer Receptors Exclusively Activated by …
inhibit or activate neurons; the so-called Designer Receptors Exclusively Activated by …
Demon voltammetry and analysis software: analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures
The fast sampling rates of fast scan cyclic voltammetry make it a favorable method for
measuring changes in brain monoamine release and uptake kinetics in slice, anesthetized, and …
measuring changes in brain monoamine release and uptake kinetics in slice, anesthetized, and …
The hypocretin–orexin system regulates cocaine self‐administration via actions on the mesolimbic dopamine system
Recent evidence suggests that the hypocretin–orexin system participates in the regulation
of reinforcement processes. The current studies examined the extent to which hypocretin …
of reinforcement processes. The current studies examined the extent to which hypocretin …
Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration
… Consistent with this, SB-334867 attenuates cocaine-induced increases in both tonic and
phasic DA activity and reduces the effects of cocaine on DA uptake inhibition (Espaņa et al. …
phasic DA activity and reduces the effects of cocaine on DA uptake inhibition (Espaņa et al. …