Alzheimer’s disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …

The repeated failures of amyloid-targeting therapies have challenged our narrow understanding
of Alzheimer’s disease (AD) pathogenesis and inspired wide-ranging investigations into …

All seven lysine residues in ubiquitin contribute to the synthesis of polyubiquitin chains on
protein substrates. Whereas K48-linked chains are well established as mediators of …

Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …

The biological processes that are disrupted in the Alzheimer’s disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …

The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43)
is a common histopathological hallmark of the amyotrophic lateral sclerosis and …

Research studies suggest that tumor-related angiogenesis contributes to the phenotype of
malignant gliomas. We assessed the effect of local delivery of the angiogenesis inhibitor …

Alzheimer’s disease (AD) pathology develops many years before the onset of cognitive
symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into plaques …

… The FDR was estimated by the number of decoy matches (nd) and total number of assigned
matches (nt). FDR = 2*nd/nt, assuming mismatches in the original database were the same …

Here, we report proteomic analyses of 129 human cortical tissues to define changes associated
with the asymptomatic and symptomatic stages of Alzheimer's disease (AD). Network …