RORα, a pivotal nuclear receptor for Purkinje neuron survival and differentiation: from development to ageing

F Boukhtouche, M Doulazmi, F Frederic, I Dusart… - The Cerebellum, 2006 - Springer
… Matysiak-Scholze U, Nehls M. The structural integrity of ROR alpha isoforms is mutated in
staggerer … Bradley P, Berry M. Quantitative effects of climbing fibre deafferentiation on the adult …

Safety and efficacy of subcutaneous night-time only apomorphine infusion to treat insomnia in patients with Parkinson's disease (APOMORPHEE): a multicentre …

…, S Lacombe, M Vidailhet, I Arnulf, M Doulazmi… - The Lancet …, 2022 - thelancet.com
Background Insomnia is a frequent complaint of patients with Parkinson's disease, and it
negatively affects quality of life. Drugs that improve both sleep and parkinsonism would be of …

[HTML][HTML] Low-intensity electromagnetic fields induce human cryptochrome to modulate intracellular reactive oxygen species

…, C Niessner, F Rouyer, A Klarsfeld, M Doulazmi… - PLoS …, 2018 - journals.plos.org
Exposure to man-made electromagnetic fields (EMFs), which increasingly pollute our environment,
have consequences for human health about which there is continuing ignorance and …

New insights into the regulatory function of CYFIP1 in the context of WAVE-and FMRP-containing complexes

…, A Raas-Rothschild, M Doulazmi… - Disease Models & …, 2017 - journals.biologists.com
Cytoplasmic FMRP interacting protein 1 (CYFIP1) is a candidate gene for intellectual
disability (ID), autism, schizophrenia and epilepsy. It is a member of a family of proteins that is …

Neural circuit repair by low-intensity magnetic stimulation requires cellular magnetoreceptors and specific stimulation patterns

T Dufor, S Grehl, AD Tang, M Doulazmi, M Traoré… - Science …, 2019 - science.org
Although electromagnetic brain stimulation is a promising treatment in neurology and
psychiatry, clinical outcomes are variable, and underlying mechanisms are ill-defined, which …

[HTML][HTML] Long-term effect of apomorphine infusion in advanced Parkinson's disease: a real-life study

B Meira, B Degos, E Corsetti, M Doulazmi… - npj Parkinson's …, 2021 - nature.com
Long-term effects of continuous subcutaneous apomorphine infusion (CSAI) on health-related
quality of life (HRQoL) and predictors of CSAI discontinuation are poorly known. Data from …

Mature Purkinje cells require the retinoic acid-related orphan receptor-α (RORα) to maintain climbing fiber mono-innervation and other adult characteristics

…, MP Morel, R Wehrlé, M Doulazmi… - Journal of …, 2013 - Soc Neuroscience
Neuronal maturation during development is a multistep process regulated by transcription
factors. The transcription factor RORα (retinoic acid-related orphan receptor α) is necessary …

Efficacy of caffeine in ADCY5‐related dyskinesia: A retrospective study

…, C Tranchant, M Doulazmi, M Vidailhet… - Movement …, 2022 - Wiley Online Library
Background ADCY5‐related dyskinesia is characterized by early‐onset movement disorders.
There is currently no validated treatment, but anecdotal clinical reports and biological …

Thyroid hormone triggers the developmental loss of axonal regenerative capacity via thyroid hormone receptor α1 and krüppel-like factor 9 in Purkinje cells

…, C Lebrun, R Wehrlé, M Doulazmi… - Proceedings of the …, 2012 - National Acad Sciences
Neurons in the CNS of higher vertebrates lose their ability to regenerate their axons at a
stage of development that coincides with peak circulating thyroid hormone (T 3 ) levels. Here, …

[HTML][HTML] Mutations in the netrin-1 gene cause congenital mirror movements

…, C Fouquet, M Doulazmi, M Vidailhet… - The Journal of …, 2017 - Am Soc Clin Investig
Netrin-1 is a secreted protein that was first identified 20 years ago as an axon guidance
molecule that regulates midline crossing in the CNS. It plays critical roles in various tissues …