Early overnutrition results in early-onset arcuate leptin resistance and increased sensitivity to high-fat diet
MM Glavas, MA Kirigiti, XQ Xiao, PJ Enriori… - …, 2010 - academic.oup.com
Childhood obesity increases the risk of adult obesity and diabetes, suggesting that early
overnutrition permanently programs altered energy and glucose homeostasis. In the present …
overnutrition permanently programs altered energy and glucose homeostasis. In the present …
[HTML][HTML] Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models
…, C True, SR Lindsley, MA Kirigiti… - The Journal of …, 2023 - Am Soc Clin Investig
The adipose-derived hormone leptin acts via its receptor (LepRb) in the brain to control
energy balance. A potentially unidentified population of GABAergic hypothalamic LepRb …
energy balance. A potentially unidentified population of GABAergic hypothalamic LepRb …
Maternal high‐fat diet and obesity impact palatable food intake and dopamine signaling in nonhuman primate offspring
HM Rivera, P Kievit, MA Kirigiti, LA Bauman… - …, 2015 - Wiley Online Library
Objective To utilize a nonhuman primate model to examine the impact of maternal high‐fat
diet (HFD) consumption and pre‐pregnancy obesity on offspring intake of palatable food and …
diet (HFD) consumption and pre‐pregnancy obesity on offspring intake of palatable food and …
Developmental switch of leptin signaling in arcuate nucleus neurons
…, MA Kirigiti, MS Smith, MA Cowley… - Journal of …, 2014 - Soc Neuroscience
Leptin is well known for its role in the regulation of energy homeostasis in adults, a mechanism
that at least partially results from the inhibition of the activity of NPY/AgRP/GABA neurons …
that at least partially results from the inhibition of the activity of NPY/AgRP/GABA neurons …
Leptin is not the critical signal for kisspeptin or luteinising hormone restoration during exit from negative energy balance
Low levels of the adipocyte hormone leptin are considered to be the key signal contributing
to inhibited gonadotrophin‐releasing hormone (GnRH) release and reproductive acyclicity …
to inhibited gonadotrophin‐releasing hormone (GnRH) release and reproductive acyclicity …
Leptin stimulates neuropeptide Y and cocaine amphetamine-regulated transcript coexpressing neuronal activity in the dorsomedial hypothalamus in diet-induced …
Neuropeptide Y (NPY) neurons in both the arcuate nucleus of the hypothalamus (ARH) and
the dorsomedial hypothalamus (DMH) have been implicated in food intake and obesity. …
the dorsomedial hypothalamus (DMH) have been implicated in food intake and obesity. …
Proinflammatory endothelial activation detected by molecular imaging in obese nonhuman primates coincides with onset of insulin resistance and progressively …
SM Chadderdon, JT Belcik, L Bader, MA Kirigiti… - Circulation, 2014 - Am Heart Assoc
Background— Inflammation and insulin resistance (IR) are associated processes that
potentiate risk for cardiovascular disease in obesity. The temporal relation between IR and …
potentiate risk for cardiovascular disease in obesity. The temporal relation between IR and …
Regulation of food intake and gonadotropin-releasing hormone/luteinizing hormone during lactation: role of insulin and leptin
J Xu, MA Kirigiti, KL Grove, MS Smith - Endocrinology, 2009 - academic.oup.com
Negative energy balance during lactation is reflected by low levels of insulin and leptin and
is associated with chronic hyperphagia and suppressed GnRH/LH activity. We studied …
is associated with chronic hyperphagia and suppressed GnRH/LH activity. We studied …
Maternal and postnatal high-fat diet consumption programs energy balance and hypothalamic melanocortin signaling in nonhuman primate offspring
…, T Frazee, G Hanna, MA Kirigiti… - American Journal …, 2017 - journals.physiology.org
Maternal high-fat-diet (HFD) consumption during pregnancy decreased fetal body weight and
impacted development of hypothalamic melanocortin neural circuitry in nonhuman primate …
impacted development of hypothalamic melanocortin neural circuitry in nonhuman primate …
GLP-1R signaling directly activates arcuate nucleus kisspeptin action in brain slices but does not rescue luteinizing hormone inhibition in ovariectomized mice during …
…, SR Lindsley, MA Kirigiti, B Bennett, MA Bosch… - Eneuro, 2017 - eneuro.org
Kisspeptin (Kiss1) neurons in the hypothalamic arcuate nucleus (ARC) are key components
of the hypothalamic-pituitary-gonadal axis, as they regulate the basal pulsatile release of …
of the hypothalamic-pituitary-gonadal axis, as they regulate the basal pulsatile release of …